Fluorescent Determination of Uric Acid Based on Porphyrin and ZnCo 2 O 4 Nanocomposite
Advances in porphyrin chemistry have provided exciting technologies in the field of optical biosensing. Herein, we have synthesized 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) and porous Zn Co O nanorods using a simple one-pot hydrothermal method. The obtained TCPP- Zn Co O composite was th...
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| Veröffentlicht in: | Journal of fluorescence 2024-10 |
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| creator | Francis, Shijo Salim, Shamna Rajith, Leena |
| description | Advances in porphyrin chemistry have provided exciting technologies in the field of optical biosensing. Herein, we have synthesized 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) and porous Zn
Co
O
nanorods using a simple one-pot hydrothermal method. The obtained TCPP- Zn
Co
O
composite was then used for the development of a novel optical sensor for the determination of uric acid (UA), which is an important biomarker in human urine, serum or saliva for the clinical diagnosis of hyperuricemia and hypouricemia, etc. TCPP-Zn
Co
O
composite was characterized using SEM, TEM, EDAX, PXRD, FT-IR, UV-Visible, and NMR spectroscopic techniques. The fluorescence emission spectral analysis of TCPP-Zn
Co
O
was then investigated for potential applications in the detection of uric acid via the fluorescence quenching mechanism. The designed sensor showed a linear response towards the uric acid in the concentration range of 0.99 to 5.2 nM. The optical sensor exhibits a sensitive response to uric acid with a detection limit of 0.015 nM. The sensor was employed to quantify UA in spiked human urine samples and artificial urine with satisfactory results. |
| format | Article |
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Co
O
nanorods using a simple one-pot hydrothermal method. The obtained TCPP- Zn
Co
O
composite was then used for the development of a novel optical sensor for the determination of uric acid (UA), which is an important biomarker in human urine, serum or saliva for the clinical diagnosis of hyperuricemia and hypouricemia, etc. TCPP-Zn
Co
O
composite was characterized using SEM, TEM, EDAX, PXRD, FT-IR, UV-Visible, and NMR spectroscopic techniques. The fluorescence emission spectral analysis of TCPP-Zn
Co
O
was then investigated for potential applications in the detection of uric acid via the fluorescence quenching mechanism. The designed sensor showed a linear response towards the uric acid in the concentration range of 0.99 to 5.2 nM. The optical sensor exhibits a sensitive response to uric acid with a detection limit of 0.015 nM. The sensor was employed to quantify UA in spiked human urine samples and artificial urine with satisfactory results.</description><identifier>EISSN: 1573-4994</identifier><identifier>PMID: 39425835</identifier><language>eng</language><publisher>Netherlands</publisher><ispartof>Journal of fluorescence, 2024-10</ispartof><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39425835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Francis, Shijo</creatorcontrib><creatorcontrib>Salim, Shamna</creatorcontrib><creatorcontrib>Rajith, Leena</creatorcontrib><title>Fluorescent Determination of Uric Acid Based on Porphyrin and ZnCo 2 O 4 Nanocomposite</title><title>Journal of fluorescence</title><addtitle>J Fluoresc</addtitle><description>Advances in porphyrin chemistry have provided exciting technologies in the field of optical biosensing. Herein, we have synthesized 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) and porous Zn
Co
O
nanorods using a simple one-pot hydrothermal method. The obtained TCPP- Zn
Co
O
composite was then used for the development of a novel optical sensor for the determination of uric acid (UA), which is an important biomarker in human urine, serum or saliva for the clinical diagnosis of hyperuricemia and hypouricemia, etc. TCPP-Zn
Co
O
composite was characterized using SEM, TEM, EDAX, PXRD, FT-IR, UV-Visible, and NMR spectroscopic techniques. The fluorescence emission spectral analysis of TCPP-Zn
Co
O
was then investigated for potential applications in the detection of uric acid via the fluorescence quenching mechanism. The designed sensor showed a linear response towards the uric acid in the concentration range of 0.99 to 5.2 nM. The optical sensor exhibits a sensitive response to uric acid with a detection limit of 0.015 nM. The sensor was employed to quantify UA in spiked human urine samples and artificial urine with satisfactory results.</description><issn>1573-4994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFjr0KwjAYAIMgtv68gnwvUKhNiu2o1eKkDurgUmKSYqT5IUmHvr0OOjsdHDfcCMWrfI0TUpYkQlPvX2malgUpJijCJcnyAucxutVdb5zwTOgAOxGEU1LTII0G08LVSQYbJjlsqRccPvZsnH0OTmqgmsNdVwYyOAGBI9WGGWWNl0HM0bilnReLL2doWe8v1SGx_UMJ3lgnFXVD8xvBf4M32jw9UA</recordid><startdate>20241019</startdate><enddate>20241019</enddate><creator>Francis, Shijo</creator><creator>Salim, Shamna</creator><creator>Rajith, Leena</creator><scope>NPM</scope></search><sort><creationdate>20241019</creationdate><title>Fluorescent Determination of Uric Acid Based on Porphyrin and ZnCo 2 O 4 Nanocomposite</title><author>Francis, Shijo ; Salim, Shamna ; Rajith, Leena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_394258353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Francis, Shijo</creatorcontrib><creatorcontrib>Salim, Shamna</creatorcontrib><creatorcontrib>Rajith, Leena</creatorcontrib><collection>PubMed</collection><jtitle>Journal of fluorescence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Francis, Shijo</au><au>Salim, Shamna</au><au>Rajith, Leena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescent Determination of Uric Acid Based on Porphyrin and ZnCo 2 O 4 Nanocomposite</atitle><jtitle>Journal of fluorescence</jtitle><addtitle>J Fluoresc</addtitle><date>2024-10-19</date><risdate>2024</risdate><eissn>1573-4994</eissn><abstract>Advances in porphyrin chemistry have provided exciting technologies in the field of optical biosensing. Herein, we have synthesized 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) and porous Zn
Co
O
nanorods using a simple one-pot hydrothermal method. The obtained TCPP- Zn
Co
O
composite was then used for the development of a novel optical sensor for the determination of uric acid (UA), which is an important biomarker in human urine, serum or saliva for the clinical diagnosis of hyperuricemia and hypouricemia, etc. TCPP-Zn
Co
O
composite was characterized using SEM, TEM, EDAX, PXRD, FT-IR, UV-Visible, and NMR spectroscopic techniques. The fluorescence emission spectral analysis of TCPP-Zn
Co
O
was then investigated for potential applications in the detection of uric acid via the fluorescence quenching mechanism. The designed sensor showed a linear response towards the uric acid in the concentration range of 0.99 to 5.2 nM. The optical sensor exhibits a sensitive response to uric acid with a detection limit of 0.015 nM. The sensor was employed to quantify UA in spiked human urine samples and artificial urine with satisfactory results.</abstract><cop>Netherlands</cop><pmid>39425835</pmid></addata></record> |
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| title | Fluorescent Determination of Uric Acid Based on Porphyrin and ZnCo 2 O 4 Nanocomposite |
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