Hepatotoxicity of valproic acid treatment

Hepatotoxicity of valproic acid (VPA) is reported in a psychomotor retarded boy. A four-month antiepileptic therapy was followed by a combined VPA/phenytoin treatment where-upon, two months later, the patient died in a hepatic coma. In the final state the metabolic pattern of VPA was still found wit...

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Veröffentlicht in:	Klinische Pädiatrie 1985-09, Vol.197 (5), p.431
Hauptverfasser:	Keulen, F P, Kochen, W
Format:	Artikel
Sprache:	ger
Schlagworte:	Child, Preschool Drug Therapy, Combination Epilepsy, Tonic-Clonic - complications Epilepsy, Tonic-Clonic - drug therapy Epilepsy, Tonic-Clonic - metabolism Humans Liver - drug effects Male Psychomotor Disorders - complications Psychomotor Disorders - drug therapy Psychomotor Disorders - metabolism Time Factors Valproic Acid - metabolism Valproic Acid - poisoning
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