FTO-mediated DSP m 6 A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors

Growth hormone-secreting pituitary neuroendocrine tumors can be pathologically classified into densely granulated (DGGH) and sparsely granulated types (SGGH). SGGH is more aggressive and associated with a poorer prognosis. While epigenetic regulation is vital in tumorigenesis and progression, the ro...

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Veröffentlicht in:	Molecular cancer 2024-09, Vol.23 (1), p.205
Hauptverfasser:	Zou, Yunzhi, Bao, Xiaoqiong, Li, Depei, Ye, Zhen, Xiang, Rong, Yang, Yuanzhong, Zhu, Zhe, Chen, Ziming, Zeng, Lingxing, Xue, Chunling, Zhao, Hongzhe, Yao, Boyuan, Zhang, Qilin, Yan, Zeming, Deng, Zekun, Cheng, Jintong, Yue, Guanghao, Hu, Wanming, Zhao, Jixiang, Bai, Ruihong, Zhang, Zhenhua, Liu, Aiqun, Zhang, Jialiang, Zuo, Zhixiang, Jiang, Xiaobing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - metabolism Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism Animals Cell Line, Tumor Demethylation Female Gene Expression Regulation, Neoplastic Growth Hormone-Secreting Pituitary Adenoma - genetics Growth Hormone-Secreting Pituitary Adenoma - metabolism Growth Hormone-Secreting Pituitary Adenoma - pathology Humans Male Mice Neuroendocrine Tumors - genetics Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology Pituitary Neoplasms - genetics Pituitary Neoplasms - metabolism Pituitary Neoplasms - pathology
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