Dissociation between the anti-allodynic effects of fingolimod (FTY720) and desensitization of S1P 1 receptor-mediated G-protein activation in a mouse model of sciatic nerve injury

Sphingosine-1-phosphate (S1P) receptor (S1PR) agonists, such as fingolimod (FTY720), alleviate nociception in preclinical pain models by either activation (agonism) or inhibition (functional antagonism) of S1PR type-1 (S1PR1). However, the dose-dependence and temporal relationship between reversal o...

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Veröffentlicht in:	Neuropharmacology 2024-12, Vol.261, p.110165
Hauptverfasser:	Pondelick, Abby M, Moncayo, Lauren V, Donvito, Giulia, McLane, Virginia D, Gillespie, James C, Hauser, Kurt F, Spiegel, Sarah, Lichtman, Aron H, Sim-Selley, Laura J, Selley, Dana E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Dose-Response Relationship, Drug Female Fingolimod Hydrochloride - pharmacology Hyperalgesia - drug therapy Hyperalgesia - metabolism Male Mice Mice, Inbred C57BL Neuralgia - drug therapy Neuralgia - metabolism Oxadiazoles - pharmacology Receptors, Lysosphingolipid - agonists Receptors, Lysosphingolipid - metabolism Sciatic Nerve - drug effects Sciatic Nerve - injuries Sciatic Neuropathy - drug therapy Sciatic Neuropathy - metabolism Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine 1 Phosphate Receptor Modulators - pharmacology Sphingosine-1-Phosphate Receptors - agonists Sphingosine-1-Phosphate Receptors - metabolism
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