Cancer cell stiffening via CoQ 10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

CoQ (Coenzyme Q ) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer development and progression. Here, we show that CoQ and its bio...

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Veröffentlicht in:	Nature communications 2024-09, Vol.15 (1), p.8214
Hauptverfasser:	Tosi, Giovanni, Paoli, Alessandro, Zuccolotto, Gaia, Turco, Emilia, Simonato, Manuela, Tosoni, Daniela, Tucci, Francesco, Lugato, Pietro, Giomo, Monica, Elvassore, Nicola, Rosato, Antonio, Cogo, Paola, Pece, Salvatore, Santoro, Massimo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Membrane - metabolism Extracellular Matrix - metabolism Female Ferroptosis - genetics Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Signal Transduction Ubiquinone - analogs & derivatives Ubiquinone - metabolism
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