Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells

Dihydrofluorouracil (FUH2), the initial catabolite of 5-fluorouracil (FUra), was examined to determine whether this derivative had antitumor activity or host cell (bone marrow) toxicity. Studies were undertaken with Ehrlich ascites tumor and bone marrow cells isolated from CF-1 mice. Cells were expo...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1985-10, Vol.45 (10), p.4900-4903
Hauptverfasser:	DIASIO, R. B, SCHUETS, J. D, WALLACE, H. J, SOMMADOSSI, J.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology beta-Alanine - analogs & derivatives beta-Alanine - pharmacology Biological and medical sciences Breast Neoplasms - pathology Carcinoma, Ehrlich Tumor - pathology Cell Line Cell Survival - drug effects Female Fluorouracil - analogs & derivatives Fluorouracil - metabolism Fluorouracil - pharmacology General aspects Humans Male Medical sciences Mice Mice, Inbred Strains Pharmacology. Drug treatments Thymidylate Synthase - antagonists & inhibitors
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