Metabolism, Covalent Binding, and Mutagenicity of Aflatoxin B1 by Liver Extracts From Rats of Various Ages

The ability of S-9 fractions isolated from the livers of 4-, 12-, and 26-month-old male inbred F344 rats to activate and metabolize the hepatocarcinogen aflatoxin B1 [(AFB1) CAS: 1162-65-8] was studied. The following observations were made: 1) The activation of APB1 to compounds that are mutagenic i...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1985-01, Vol.74 (1), p.95-103
Hauptverfasser:	Jayaraj, Andrew, Hardwick, James P., Diller, Thomas W., Richardson, Arlan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin B1 Aflatoxins - metabolism Aflatoxins - pharmacology Age Factors Animals Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism Glucuronosyltransferase - metabolism Liver - metabolism Male Medical sciences Microsomes, Liver - enzymology Mutagenicity Tests Mutagens NADPH-Ferrihemoprotein Reductase - metabolism Plant poisons toxicology Rats Rats, Inbred F344 Toxicology
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