Deciphering internal and external factors influencing intestinal junctional complexes
The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the intricate exchange between internal and external environments. Anchored by evolutionarily conserved junctional complexes, this barrier meticulously regulates paracellular permeability in essentially all living...
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Veröffentlicht in: | Gut microbes 2024-12, Vol.16 (1), p.2389320 |
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description | The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the intricate exchange between internal and external environments. Anchored by evolutionarily conserved junctional complexes, this barrier meticulously regulates paracellular permeability in essentially all living organisms. Disruptions in intestinal junctional complexes, prevalent in inflammatory bowel diseases and irritable bowel syndrome, compromise barrier integrity and often lead to the notorious "leaky gut" syndrome. Critical to the maintenance of the intestinal barrier is a finely orchestrated network of intrinsic and extrinsic factors that modulate the expression, composition, and functionality of junctional complexes. This review navigates through the composition of key junctional complex components and the common methods used to assess intestinal permeability. It also explores the critical intracellular signaling pathways that modulate these junctional components. Lastly, we delve into the complex dynamics between the junctional complexes, microbial communities, and environmental chemicals in shaping the intestinal barrier function. Comprehending this intricate interplay holds paramount importance in unraveling the pathophysiology of gastrointestinal disorders. Furthermore, it lays the foundation for the development of precise therapeutic interventions targeting barrier dysfunction. |
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Anchored by evolutionarily conserved junctional complexes, this barrier meticulously regulates paracellular permeability in essentially all living organisms. Disruptions in intestinal junctional complexes, prevalent in inflammatory bowel diseases and irritable bowel syndrome, compromise barrier integrity and often lead to the notorious "leaky gut" syndrome. Critical to the maintenance of the intestinal barrier is a finely orchestrated network of intrinsic and extrinsic factors that modulate the expression, composition, and functionality of junctional complexes. This review navigates through the composition of key junctional complex components and the common methods used to assess intestinal permeability. It also explores the critical intracellular signaling pathways that modulate these junctional components. Lastly, we delve into the complex dynamics between the junctional complexes, microbial communities, and environmental chemicals in shaping the intestinal barrier function. Comprehending this intricate interplay holds paramount importance in unraveling the pathophysiology of gastrointestinal disorders. Furthermore, it lays the foundation for the development of precise therapeutic interventions targeting barrier dysfunction.</description><identifier>ISSN: 1949-0976</identifier><identifier>ISSN: 1949-0984</identifier><identifier>EISSN: 1949-0984</identifier><identifier>DOI: 10.1080/19490976.2024.2389320</identifier><identifier>PMID: 39150987</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; C. elegans ; Drosophila ; extrinsic modulators ; Gastrointestinal diseases ; Gastrointestinal Microbiome ; Gut barrier ; Humans ; Inflammatory Bowel Diseases - metabolism ; Inflammatory Bowel Diseases - physiopathology ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - microbiology ; intrinsic modulators ; Irritable Bowel Syndrome - metabolism ; Irritable Bowel Syndrome - physiopathology ; junctional complex ; microbes ; mouse model ; Permeability ; Review ; Signal Transduction ; Tight Junctions - metabolism</subject><ispartof>Gut microbes, 2024-12, Vol.16 (1), p.2389320</ispartof><rights>2024 The Author(s). 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Published with license by Taylor & Francis Group, LLC. 2024 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-5541-6685</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332634/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332634/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27502,27924,27925,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39150987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markovich, Zachary</creatorcontrib><creatorcontrib>Abreu, Adriana</creatorcontrib><creatorcontrib>Sheng, Yi</creatorcontrib><creatorcontrib>Han, Sung Min</creatorcontrib><creatorcontrib>Xiao, Rui</creatorcontrib><title>Deciphering internal and external factors influencing intestinal junctional complexes</title><title>Gut microbes</title><addtitle>Gut Microbes</addtitle><description>The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the intricate exchange between internal and external environments. Anchored by evolutionarily conserved junctional complexes, this barrier meticulously regulates paracellular permeability in essentially all living organisms. Disruptions in intestinal junctional complexes, prevalent in inflammatory bowel diseases and irritable bowel syndrome, compromise barrier integrity and often lead to the notorious "leaky gut" syndrome. Critical to the maintenance of the intestinal barrier is a finely orchestrated network of intrinsic and extrinsic factors that modulate the expression, composition, and functionality of junctional complexes. This review navigates through the composition of key junctional complex components and the common methods used to assess intestinal permeability. It also explores the critical intracellular signaling pathways that modulate these junctional components. Lastly, we delve into the complex dynamics between the junctional complexes, microbial communities, and environmental chemicals in shaping the intestinal barrier function. Comprehending this intricate interplay holds paramount importance in unraveling the pathophysiology of gastrointestinal disorders. Furthermore, it lays the foundation for the development of precise therapeutic interventions targeting barrier dysfunction.</description><subject>Animals</subject><subject>C. elegans</subject><subject>Drosophila</subject><subject>extrinsic modulators</subject><subject>Gastrointestinal diseases</subject><subject>Gastrointestinal Microbiome</subject><subject>Gut barrier</subject><subject>Humans</subject><subject>Inflammatory Bowel Diseases - metabolism</subject><subject>Inflammatory Bowel Diseases - physiopathology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - microbiology</subject><subject>intrinsic modulators</subject><subject>Irritable Bowel Syndrome - metabolism</subject><subject>Irritable Bowel Syndrome - physiopathology</subject><subject>junctional complex</subject><subject>microbes</subject><subject>mouse model</subject><subject>Permeability</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>Tight Junctions - metabolism</subject><issn>1949-0976</issn><issn>1949-0984</issn><issn>1949-0984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVUk1vEzEQtRCIVqE_AZQjl4Txx_rjBKi0UKkSF3q2Zm1v6shZB-8ubf89XpJU1BeP5z29seY9Qt5TWFPQ8IkaYcAouWbAxJpxbTiDV-R87q_AaPH6uVbyjFwMwxbqEUKB5G_JGTe0qTR1Tu6-BRf396HEfrOM_RhKj2mJvV-Gx-OjQzfmMlS0S1Po3Yk5jHGGt1Pvxpjn0uXdPoXHMLwjbzpMQ7g43gtyd3316_LH6vbn95vLr7crz6UaV1I7hwAcvQbWqA7RQcsazb3njcG2bZwWUnDBHYSgTOdbL6kA3ykGigW-IDcHXZ9xa_cl7rA82YzR_mvksrFYxuhSsI1HBd47xbQWraMGUGtN0bW61Y30VevzQWs_tbvgXejHgumF6Eukj_d2k_9YSjlnsn5yQT4eFUr-PdX92F0cXEgJ-5CnwXIw1SnJ6Ez98P-w5yknYyrhy4FQt57LDh9ySd6O-JRy6QpWF6oeBTvHwZ7iYOc42GMc-F9WY6hn</recordid><startdate>20241231</startdate><enddate>20241231</enddate><creator>Markovich, Zachary</creator><creator>Abreu, Adriana</creator><creator>Sheng, Yi</creator><creator>Han, Sung Min</creator><creator>Xiao, Rui</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5541-6685</orcidid></search><sort><creationdate>20241231</creationdate><title>Deciphering internal and external factors influencing intestinal junctional complexes</title><author>Markovich, Zachary ; Abreu, Adriana ; Sheng, Yi ; Han, Sung Min ; Xiao, Rui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d367t-68cca003ad80257faac0b2583dd359abb5c8464343c0ee79fdbd6140df72072e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>C. elegans</topic><topic>Drosophila</topic><topic>extrinsic modulators</topic><topic>Gastrointestinal diseases</topic><topic>Gastrointestinal Microbiome</topic><topic>Gut barrier</topic><topic>Humans</topic><topic>Inflammatory Bowel Diseases - metabolism</topic><topic>Inflammatory Bowel Diseases - physiopathology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - microbiology</topic><topic>intrinsic modulators</topic><topic>Irritable Bowel Syndrome - metabolism</topic><topic>Irritable Bowel Syndrome - physiopathology</topic><topic>junctional complex</topic><topic>microbes</topic><topic>mouse model</topic><topic>Permeability</topic><topic>Review</topic><topic>Signal Transduction</topic><topic>Tight Junctions - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markovich, Zachary</creatorcontrib><creatorcontrib>Abreu, Adriana</creatorcontrib><creatorcontrib>Sheng, Yi</creatorcontrib><creatorcontrib>Han, Sung Min</creatorcontrib><creatorcontrib>Xiao, Rui</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Gut microbes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markovich, Zachary</au><au>Abreu, Adriana</au><au>Sheng, Yi</au><au>Han, Sung Min</au><au>Xiao, Rui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deciphering internal and external factors influencing intestinal junctional complexes</atitle><jtitle>Gut microbes</jtitle><addtitle>Gut Microbes</addtitle><date>2024-12-31</date><risdate>2024</risdate><volume>16</volume><issue>1</issue><spage>2389320</spage><pages>2389320-</pages><issn>1949-0976</issn><issn>1949-0984</issn><eissn>1949-0984</eissn><abstract>The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the intricate exchange between internal and external environments. Anchored by evolutionarily conserved junctional complexes, this barrier meticulously regulates paracellular permeability in essentially all living organisms. Disruptions in intestinal junctional complexes, prevalent in inflammatory bowel diseases and irritable bowel syndrome, compromise barrier integrity and often lead to the notorious "leaky gut" syndrome. Critical to the maintenance of the intestinal barrier is a finely orchestrated network of intrinsic and extrinsic factors that modulate the expression, composition, and functionality of junctional complexes. This review navigates through the composition of key junctional complex components and the common methods used to assess intestinal permeability. It also explores the critical intracellular signaling pathways that modulate these junctional components. Lastly, we delve into the complex dynamics between the junctional complexes, microbial communities, and environmental chemicals in shaping the intestinal barrier function. 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subjects | Animals C. elegans Drosophila extrinsic modulators Gastrointestinal diseases Gastrointestinal Microbiome Gut barrier Humans Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - physiopathology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology intrinsic modulators Irritable Bowel Syndrome - metabolism Irritable Bowel Syndrome - physiopathology junctional complex microbes mouse model Permeability Review Signal Transduction Tight Junctions - metabolism |
title | Deciphering internal and external factors influencing intestinal junctional complexes |
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