Multimodal effects of an extracellular matrix on cellular morphology, dynamics and functionality
Articular cartilage defects can lead to pain and even disability in patients and have significant socioeconomic loss. Repairing articular cartilage defects remains a long-term challenge in medicine owing to the limited ability of cartilage to regenerate. At present, the treatment methods adopted in...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-08, Vol.12 (32), p.7946-7958 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Chen, Xin Liu, Wenhao Su, Chi Shan, Jianyang Li, Xiang Chai, Yimin Yu, Yaling Wen, Gen |
| description | Articular cartilage defects can lead to pain and even disability in patients and have significant socioeconomic loss. Repairing articular cartilage defects remains a long-term challenge in medicine owing to the limited ability of cartilage to regenerate. At present, the treatment methods adopted in clinical practice have many limitations, thereby necessitating the rapid development of biomaterials. Among them, decellularized biomaterials have been particularly prominent, with numerous breakthroughs in research progress and translational applications. Although many studies show that decellularized cartilage biomaterials promote tissue regeneration, any differences in cellular morphology, dynamics, and functionality among various biomaterials upon comparison have not been reported. In this study, we prepared cartilage-derived extracellular matrix (cdECM) biomaterials with different bioactive contents and various physical properties to compare their effects on the morphology, dynamics and functionality of chondrocytes. This cellular multimodal analysis of the characteristics of cdECM biomaterials provided a theoretical basis for understanding the interactions between biomaterials and cells, thus laying an experimental foundation for the translation and application of decellularized cartilage biomaterials in the treatment of cartilage defects.
Multimodal analysis of the effects of cdECM biomaterials with different topological morphologies on chondrocyte morphologies, dynamics and functionality. |
| doi_str_mv | 10.1039/d4tb00360h |
| format | Article |
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Multimodal analysis of the effects of cdECM biomaterials with different topological morphologies on chondrocyte morphologies, dynamics and functionality.</description><identifier>ISSN: 2050-750X</identifier><identifier>ISSN: 2050-7518</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d4tb00360h</identifier><identifier>PMID: 39041314</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biomaterials ; Biomedical materials ; Cartilage ; Cartilage, Articular ; Cell Proliferation - drug effects ; Cells, Cultured ; Chondrocytes ; Chondrocytes - cytology ; Defects ; Extracellular matrix ; Extracellular Matrix - chemistry ; Extracellular Matrix - metabolism ; Humans ; Morphology ; Particle Size ; Physical characteristics ; Physical properties ; R&D ; Regeneration (physiology) ; Research & development ; Tissue engineering ; Tissue Scaffolds - chemistry</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2024-08, Vol.12 (32), p.7946-7958</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c226t-67538b88795301a7a124baf30f9d2c11f09b84279c6ac6aac2fd08b5d41e4de03</cites><orcidid>0000-0001-6116-4330</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39041314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Liu, Wenhao</creatorcontrib><creatorcontrib>Su, Chi</creatorcontrib><creatorcontrib>Shan, Jianyang</creatorcontrib><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Chai, Yimin</creatorcontrib><creatorcontrib>Yu, Yaling</creatorcontrib><creatorcontrib>Wen, Gen</creatorcontrib><title>Multimodal effects of an extracellular matrix on cellular morphology, dynamics and functionality</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Articular cartilage defects can lead to pain and even disability in patients and have significant socioeconomic loss. Repairing articular cartilage defects remains a long-term challenge in medicine owing to the limited ability of cartilage to regenerate. At present, the treatment methods adopted in clinical practice have many limitations, thereby necessitating the rapid development of biomaterials. Among them, decellularized biomaterials have been particularly prominent, with numerous breakthroughs in research progress and translational applications. Although many studies show that decellularized cartilage biomaterials promote tissue regeneration, any differences in cellular morphology, dynamics, and functionality among various biomaterials upon comparison have not been reported. In this study, we prepared cartilage-derived extracellular matrix (cdECM) biomaterials with different bioactive contents and various physical properties to compare their effects on the morphology, dynamics and functionality of chondrocytes. This cellular multimodal analysis of the characteristics of cdECM biomaterials provided a theoretical basis for understanding the interactions between biomaterials and cells, thus laying an experimental foundation for the translation and application of decellularized cartilage biomaterials in the treatment of cartilage defects.
Multimodal analysis of the effects of cdECM biomaterials with different topological morphologies on chondrocyte morphologies, dynamics and functionality.</description><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Cartilage</subject><subject>Cartilage, Articular</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Chondrocytes</subject><subject>Chondrocytes - cytology</subject><subject>Defects</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - chemistry</subject><subject>Extracellular Matrix - metabolism</subject><subject>Humans</subject><subject>Morphology</subject><subject>Particle Size</subject><subject>Physical characteristics</subject><subject>Physical properties</subject><subject>R&D</subject><subject>Regeneration (physiology)</subject><subject>Research & development</subject><subject>Tissue engineering</subject><subject>Tissue Scaffolds - chemistry</subject><issn>2050-750X</issn><issn>2050-7518</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0ctKxDAUBuAgioq6ca8E3Ig4enJpmy51vIww4kbBXU1z0UrbjEkKztubcXQEQyAh-XI4_EFon8AZAVaeax5rAJbD2xrappDBqMiIWF_t4XkL7YXwDmkIkgvGN9EWK4ETRvg2erkf2th0TssWG2uNigE7i2WPzWf0Upm2HVrpcSejbz6x6_HfkfOzN9e61_kp1vNedo0K6aHGduhVbFwv2ybOd9GGlW0wez_rDnq6uX4cT0bTh9u78cV0pCjN4ygvMiZqIYoyY0BkIQnltbQMbKmpIsRCWQtOi1LlMk2pqNUg6kxzYrg2wHbQ8bLuzLuPwYRYdU1Y9Cp744ZQMRAsFxTKPNGjf_TdDT61u1AlTSoHltTJUinvQvDGVjPfdNLPKwLVIvrqij9efkc_Sfjwp-RQd0av6G_QCRwsgQ9qdfv3d-wLf06Ifg</recordid><startdate>20240814</startdate><enddate>20240814</enddate><creator>Chen, Xin</creator><creator>Liu, Wenhao</creator><creator>Su, Chi</creator><creator>Shan, Jianyang</creator><creator>Li, Xiang</creator><creator>Chai, Yimin</creator><creator>Yu, Yaling</creator><creator>Wen, Gen</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6116-4330</orcidid></search><sort><creationdate>20240814</creationdate><title>Multimodal effects of an extracellular matrix on cellular morphology, dynamics and functionality</title><author>Chen, Xin ; Liu, Wenhao ; Su, Chi ; Shan, Jianyang ; Li, Xiang ; Chai, Yimin ; Yu, Yaling ; Wen, Gen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-67538b88795301a7a124baf30f9d2c11f09b84279c6ac6aac2fd08b5d41e4de03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Cartilage</topic><topic>Cartilage, Articular</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Chondrocytes</topic><topic>Chondrocytes - cytology</topic><topic>Defects</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - chemistry</topic><topic>Extracellular Matrix - metabolism</topic><topic>Humans</topic><topic>Morphology</topic><topic>Particle Size</topic><topic>Physical characteristics</topic><topic>Physical properties</topic><topic>R&D</topic><topic>Regeneration (physiology)</topic><topic>Research & development</topic><topic>Tissue engineering</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Liu, Wenhao</creatorcontrib><creatorcontrib>Su, Chi</creatorcontrib><creatorcontrib>Shan, Jianyang</creatorcontrib><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Chai, Yimin</creatorcontrib><creatorcontrib>Yu, Yaling</creatorcontrib><creatorcontrib>Wen, Gen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xin</au><au>Liu, Wenhao</au><au>Su, Chi</au><au>Shan, Jianyang</au><au>Li, Xiang</au><au>Chai, Yimin</au><au>Yu, Yaling</au><au>Wen, Gen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multimodal effects of an extracellular matrix on cellular morphology, dynamics and functionality</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2024-08-14</date><risdate>2024</risdate><volume>12</volume><issue>32</issue><spage>7946</spage><epage>7958</epage><pages>7946-7958</pages><issn>2050-750X</issn><issn>2050-7518</issn><eissn>2050-7518</eissn><abstract>Articular cartilage defects can lead to pain and even disability in patients and have significant socioeconomic loss. Repairing articular cartilage defects remains a long-term challenge in medicine owing to the limited ability of cartilage to regenerate. At present, the treatment methods adopted in clinical practice have many limitations, thereby necessitating the rapid development of biomaterials. Among them, decellularized biomaterials have been particularly prominent, with numerous breakthroughs in research progress and translational applications. Although many studies show that decellularized cartilage biomaterials promote tissue regeneration, any differences in cellular morphology, dynamics, and functionality among various biomaterials upon comparison have not been reported. In this study, we prepared cartilage-derived extracellular matrix (cdECM) biomaterials with different bioactive contents and various physical properties to compare their effects on the morphology, dynamics and functionality of chondrocytes. This cellular multimodal analysis of the characteristics of cdECM biomaterials provided a theoretical basis for understanding the interactions between biomaterials and cells, thus laying an experimental foundation for the translation and application of decellularized cartilage biomaterials in the treatment of cartilage defects.
Multimodal analysis of the effects of cdECM biomaterials with different topological morphologies on chondrocyte morphologies, dynamics and functionality.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>39041314</pmid><doi>10.1039/d4tb00360h</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-6116-4330</orcidid></addata></record> |
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| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2024-08, Vol.12 (32), p.7946-7958 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomaterials Biomedical materials Cartilage Cartilage, Articular Cell Proliferation - drug effects Cells, Cultured Chondrocytes Chondrocytes - cytology Defects Extracellular matrix Extracellular Matrix - chemistry Extracellular Matrix - metabolism Humans Morphology Particle Size Physical characteristics Physical properties R&D Regeneration (physiology) Research & development Tissue engineering Tissue Scaffolds - chemistry |
| title | Multimodal effects of an extracellular matrix on cellular morphology, dynamics and functionality |
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