Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment

Attenuated measles virus (MV) exerts its oncolytic activity in malignant pleural mesothelioma (MPM) cells that lack type-I interferon (IFN-I) production or responsiveness. However, other cells in the tumor microenvironment (TME), such as myeloid cells, possess functional antiviral pathways. In this...

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Veröffentlicht in:	Oncoimmunology 2024-12, Vol.13 (1), p.2377830
Hauptverfasser:	Chatelain, Camille, Berland, Laurine, Grard, Marion, Jouand, Nicolas, Fresquet, Judith, Nader, Joëlle, Hirigoyen, Ugo, Petithomme, Tacien, Combredet, Chantal, Pons-Tostivint, Elvire, Fradin, Delphine, Treps, Lucas, Blanquart, Christophe, Boisgerault, Nicolas, Tangy, Frédéric, Fonteneau, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell Differentiation Cell Line, Tumor Coculture Techniques Humans Interferon Type I - metabolism Life Sciences Lung Neoplasms - immunology Lung Neoplasms - pathology Lung Neoplasms - therapy Lung Neoplasms - virology Macrophages - immunology Macrophages - metabolism Macrophages - virology Measles virus Measles virus - genetics Measles virus - physiology mesothelioma Mesothelioma, Malignant - pathology Mesothelioma, Malignant - therapy Monocytes - immunology Monocytes - metabolism Monocytes - virology oncolytic immunotherapy Oncolytic Virotherapy - methods Oncolytic Viruses - genetics tumor associated macrophages Tumor Microenvironment - immunology type I interferon
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