Sex differences in coronary atherosclerotic plaque activity using 18 F-sodium fluoride positron emission tomography

There are sex differences in the extent, severity, and outcomes of coronary artery disease. We aimed to assess the influence of sex on coronary atherosclerotic plaque activity measured using coronary F-sodium fluoride ( F-NaF) positron emission tomography (PET), and to determine whether F-NaF PET ha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2024-06
Hauptverfasser:	Kwiecinski, Jacek, Wang, Kang-Ling, Tzolos, Evangelos, Moss, Alastair, Daghem, Marwa, Adamson, Philip D, Dey, Damini, Molek-Dziadosz, Patrycja, Dawson, Dana, Arumugam, Parthiban, Sabharwal, Nikant, Greenwood, John P, Townend, John N, Calvert, Patrick A, Rudd, James Hf, Berman, Daniel, Verjans, Johan W, Williams, Michelle C, Slomka, Piotr, Dweck, Marc R, Newby, David E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title	European journal of nuclear medicine and molecular imaging
container_volume
creator	Kwiecinski, Jacek Wang, Kang-Ling Tzolos, Evangelos Moss, Alastair Daghem, Marwa Adamson, Philip D Dey, Damini Molek-Dziadosz, Patrycja Dawson, Dana Arumugam, Parthiban Sabharwal, Nikant Greenwood, John P Townend, John N Calvert, Patrick A Rudd, James Hf Berman, Daniel Verjans, Johan W Williams, Michelle C Slomka, Piotr Dweck, Marc R Newby, David E
description	There are sex differences in the extent, severity, and outcomes of coronary artery disease. We aimed to assess the influence of sex on coronary atherosclerotic plaque activity measured using coronary F-sodium fluoride ( F-NaF) positron emission tomography (PET), and to determine whether F-NaF PET has prognostic value in both women and men. In a post-hoc analysis of observational cohort studies of patients with coronary atherosclerosis who had undergone F-NaF PET CT angiography, we compared the coronary microcalcification activity (CMA) in women and men. Baseline F-NaF PET CT angiography was available in 999 participants (151 (15%) women) with 4282 patient-years of follow-up. Compared to men, women had lower coronary calcium scores (116 [interquartile range, 27-434] versus 205 [51-571] Agatston units; p = 0.002) and CMA values (0.0 [0.0-1.12] versus 0.53 [0.0-2.54], p = 0.01). Following matching for plaque burden by coronary calcium scores and clinical comorbidities, there was no sex-related difference in CMA values (0.0 [0.0-1.12] versus 0.0 [0.0-1.23], p = 0.21) and similar proportions of women and men had no F-NaF uptake (53.0% (n = 80) and 48.3% (n = 73); p = 0.42), or CMA values > 1.56 (21.8% (n = 33) and 21.8% (n = 33); p = 1.00). Over a median follow-up of 4.5 [4.0-6.0] years, myocardial infarction occurred in 6.6% of women (n = 10) and 7.8% of men (n = 66). Coronary microcalcification activity greater than 0 was associated with a similarly increased risk of myocardial infarction in both women (HR: 3.83; 95% CI:1.10-18.49; p = 0.04) and men (HR: 5.29; 95% CI:2.28-12.28; p
format	Article
fullrecord	<record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_38926161</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>38926161</sourcerecordid><originalsourceid>FETCH-pubmed_primary_389261613</originalsourceid><addsrcrecordid>eNqFTssKwjAQDIJYX78g-wOFVqGmZ1G8611iutWVponZROzfm4OevcwMzDAzIzEtq7LOt4WsMzFjfhRFKdeynohsI-t1ldyp4BO-oaG2RY-9RgbqQVtve-UHUOGO3rLuEgbS4Dr1jAhKB3pRGCAy9TcoJRxytg1FA20XracGwVmmkGoADTFTEsEae_PK3YeFGLeqY1x-eS5Wh_15d8xdvBpsLs6TSfOX38vN38AHgxJKsg</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Sex differences in coronary atherosclerotic plaque activity using 18 F-sodium fluoride positron emission tomography</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kwiecinski, Jacek ; Wang, Kang-Ling ; Tzolos, Evangelos ; Moss, Alastair ; Daghem, Marwa ; Adamson, Philip D ; Dey, Damini ; Molek-Dziadosz, Patrycja ; Dawson, Dana ; Arumugam, Parthiban ; Sabharwal, Nikant ; Greenwood, John P ; Townend, John N ; Calvert, Patrick A ; Rudd, James Hf ; Berman, Daniel ; Verjans, Johan W ; Williams, Michelle C ; Slomka, Piotr ; Dweck, Marc R ; Newby, David E</creator><creatorcontrib>Kwiecinski, Jacek ; Wang, Kang-Ling ; Tzolos, Evangelos ; Moss, Alastair ; Daghem, Marwa ; Adamson, Philip D ; Dey, Damini ; Molek-Dziadosz, Patrycja ; Dawson, Dana ; Arumugam, Parthiban ; Sabharwal, Nikant ; Greenwood, John P ; Townend, John N ; Calvert, Patrick A ; Rudd, James Hf ; Berman, Daniel ; Verjans, Johan W ; Williams, Michelle C ; Slomka, Piotr ; Dweck, Marc R ; Newby, David E</creatorcontrib><description>There are sex differences in the extent, severity, and outcomes of coronary artery disease. We aimed to assess the influence of sex on coronary atherosclerotic plaque activity measured using coronary F-sodium fluoride ( F-NaF) positron emission tomography (PET), and to determine whether F-NaF PET has prognostic value in both women and men. In a post-hoc analysis of observational cohort studies of patients with coronary atherosclerosis who had undergone F-NaF PET CT angiography, we compared the coronary microcalcification activity (CMA) in women and men. Baseline F-NaF PET CT angiography was available in 999 participants (151 (15%) women) with 4282 patient-years of follow-up. Compared to men, women had lower coronary calcium scores (116 [interquartile range, 27-434] versus 205 [51-571] Agatston units; p = 0.002) and CMA values (0.0 [0.0-1.12] versus 0.53 [0.0-2.54], p = 0.01). Following matching for plaque burden by coronary calcium scores and clinical comorbidities, there was no sex-related difference in CMA values (0.0 [0.0-1.12] versus 0.0 [0.0-1.23], p = 0.21) and similar proportions of women and men had no F-NaF uptake (53.0% (n = 80) and 48.3% (n = 73); p = 0.42), or CMA values > 1.56 (21.8% (n = 33) and 21.8% (n = 33); p = 1.00). Over a median follow-up of 4.5 [4.0-6.0] years, myocardial infarction occurred in 6.6% of women (n = 10) and 7.8% of men (n = 66). Coronary microcalcification activity greater than 0 was associated with a similarly increased risk of myocardial infarction in both women (HR: 3.83; 95% CI:1.10-18.49; p = 0.04) and men (HR: 5.29; 95% CI:2.28-12.28; p < 0.001). Although men present with more coronary atherosclerotic plaque than women, increased plaque activity is a strong predictor of future myocardial infarction regardless of sex.</description><identifier>EISSN: 1619-7089</identifier><identifier>PMID: 38926161</identifier><language>eng</language><publisher>Germany</publisher><ispartof>European journal of nuclear medicine and molecular imaging, 2024-06</ispartof><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38926161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwiecinski, Jacek</creatorcontrib><creatorcontrib>Wang, Kang-Ling</creatorcontrib><creatorcontrib>Tzolos, Evangelos</creatorcontrib><creatorcontrib>Moss, Alastair</creatorcontrib><creatorcontrib>Daghem, Marwa</creatorcontrib><creatorcontrib>Adamson, Philip D</creatorcontrib><creatorcontrib>Dey, Damini</creatorcontrib><creatorcontrib>Molek-Dziadosz, Patrycja</creatorcontrib><creatorcontrib>Dawson, Dana</creatorcontrib><creatorcontrib>Arumugam, Parthiban</creatorcontrib><creatorcontrib>Sabharwal, Nikant</creatorcontrib><creatorcontrib>Greenwood, John P</creatorcontrib><creatorcontrib>Townend, John N</creatorcontrib><creatorcontrib>Calvert, Patrick A</creatorcontrib><creatorcontrib>Rudd, James Hf</creatorcontrib><creatorcontrib>Berman, Daniel</creatorcontrib><creatorcontrib>Verjans, Johan W</creatorcontrib><creatorcontrib>Williams, Michelle C</creatorcontrib><creatorcontrib>Slomka, Piotr</creatorcontrib><creatorcontrib>Dweck, Marc R</creatorcontrib><creatorcontrib>Newby, David E</creatorcontrib><title>Sex differences in coronary atherosclerotic plaque activity using 18 F-sodium fluoride positron emission tomography</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>There are sex differences in the extent, severity, and outcomes of coronary artery disease. We aimed to assess the influence of sex on coronary atherosclerotic plaque activity measured using coronary F-sodium fluoride ( F-NaF) positron emission tomography (PET), and to determine whether F-NaF PET has prognostic value in both women and men. In a post-hoc analysis of observational cohort studies of patients with coronary atherosclerosis who had undergone F-NaF PET CT angiography, we compared the coronary microcalcification activity (CMA) in women and men. Baseline F-NaF PET CT angiography was available in 999 participants (151 (15%) women) with 4282 patient-years of follow-up. Compared to men, women had lower coronary calcium scores (116 [interquartile range, 27-434] versus 205 [51-571] Agatston units; p = 0.002) and CMA values (0.0 [0.0-1.12] versus 0.53 [0.0-2.54], p = 0.01). Following matching for plaque burden by coronary calcium scores and clinical comorbidities, there was no sex-related difference in CMA values (0.0 [0.0-1.12] versus 0.0 [0.0-1.23], p = 0.21) and similar proportions of women and men had no F-NaF uptake (53.0% (n = 80) and 48.3% (n = 73); p = 0.42), or CMA values > 1.56 (21.8% (n = 33) and 21.8% (n = 33); p = 1.00). Over a median follow-up of 4.5 [4.0-6.0] years, myocardial infarction occurred in 6.6% of women (n = 10) and 7.8% of men (n = 66). Coronary microcalcification activity greater than 0 was associated with a similarly increased risk of myocardial infarction in both women (HR: 3.83; 95% CI:1.10-18.49; p = 0.04) and men (HR: 5.29; 95% CI:2.28-12.28; p < 0.001). Although men present with more coronary atherosclerotic plaque than women, increased plaque activity is a strong predictor of future myocardial infarction regardless of sex.</description><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFTssKwjAQDIJYX78g-wOFVqGmZ1G8611iutWVponZROzfm4OevcwMzDAzIzEtq7LOt4WsMzFjfhRFKdeynohsI-t1ldyp4BO-oaG2RY-9RgbqQVtve-UHUOGO3rLuEgbS4Dr1jAhKB3pRGCAy9TcoJRxytg1FA20XracGwVmmkGoADTFTEsEae_PK3YeFGLeqY1x-eS5Wh_15d8xdvBpsLs6TSfOX38vN38AHgxJKsg</recordid><startdate>20240627</startdate><enddate>20240627</enddate><creator>Kwiecinski, Jacek</creator><creator>Wang, Kang-Ling</creator><creator>Tzolos, Evangelos</creator><creator>Moss, Alastair</creator><creator>Daghem, Marwa</creator><creator>Adamson, Philip D</creator><creator>Dey, Damini</creator><creator>Molek-Dziadosz, Patrycja</creator><creator>Dawson, Dana</creator><creator>Arumugam, Parthiban</creator><creator>Sabharwal, Nikant</creator><creator>Greenwood, John P</creator><creator>Townend, John N</creator><creator>Calvert, Patrick A</creator><creator>Rudd, James Hf</creator><creator>Berman, Daniel</creator><creator>Verjans, Johan W</creator><creator>Williams, Michelle C</creator><creator>Slomka, Piotr</creator><creator>Dweck, Marc R</creator><creator>Newby, David E</creator><scope>NPM</scope></search><sort><creationdate>20240627</creationdate><title>Sex differences in coronary atherosclerotic plaque activity using 18 F-sodium fluoride positron emission tomography</title><author>Kwiecinski, Jacek ; Wang, Kang-Ling ; Tzolos, Evangelos ; Moss, Alastair ; Daghem, Marwa ; Adamson, Philip D ; Dey, Damini ; Molek-Dziadosz, Patrycja ; Dawson, Dana ; Arumugam, Parthiban ; Sabharwal, Nikant ; Greenwood, John P ; Townend, John N ; Calvert, Patrick A ; Rudd, James Hf ; Berman, Daniel ; Verjans, Johan W ; Williams, Michelle C ; Slomka, Piotr ; Dweck, Marc R ; Newby, David E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_389261613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwiecinski, Jacek</creatorcontrib><creatorcontrib>Wang, Kang-Ling</creatorcontrib><creatorcontrib>Tzolos, Evangelos</creatorcontrib><creatorcontrib>Moss, Alastair</creatorcontrib><creatorcontrib>Daghem, Marwa</creatorcontrib><creatorcontrib>Adamson, Philip D</creatorcontrib><creatorcontrib>Dey, Damini</creatorcontrib><creatorcontrib>Molek-Dziadosz, Patrycja</creatorcontrib><creatorcontrib>Dawson, Dana</creatorcontrib><creatorcontrib>Arumugam, Parthiban</creatorcontrib><creatorcontrib>Sabharwal, Nikant</creatorcontrib><creatorcontrib>Greenwood, John P</creatorcontrib><creatorcontrib>Townend, John N</creatorcontrib><creatorcontrib>Calvert, Patrick A</creatorcontrib><creatorcontrib>Rudd, James Hf</creatorcontrib><creatorcontrib>Berman, Daniel</creatorcontrib><creatorcontrib>Verjans, Johan W</creatorcontrib><creatorcontrib>Williams, Michelle C</creatorcontrib><creatorcontrib>Slomka, Piotr</creatorcontrib><creatorcontrib>Dweck, Marc R</creatorcontrib><creatorcontrib>Newby, David E</creatorcontrib><collection>PubMed</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwiecinski, Jacek</au><au>Wang, Kang-Ling</au><au>Tzolos, Evangelos</au><au>Moss, Alastair</au><au>Daghem, Marwa</au><au>Adamson, Philip D</au><au>Dey, Damini</au><au>Molek-Dziadosz, Patrycja</au><au>Dawson, Dana</au><au>Arumugam, Parthiban</au><au>Sabharwal, Nikant</au><au>Greenwood, John P</au><au>Townend, John N</au><au>Calvert, Patrick A</au><au>Rudd, James Hf</au><au>Berman, Daniel</au><au>Verjans, Johan W</au><au>Williams, Michelle C</au><au>Slomka, Piotr</au><au>Dweck, Marc R</au><au>Newby, David E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in coronary atherosclerotic plaque activity using 18 F-sodium fluoride positron emission tomography</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2024-06-27</date><risdate>2024</risdate><eissn>1619-7089</eissn><abstract>There are sex differences in the extent, severity, and outcomes of coronary artery disease. We aimed to assess the influence of sex on coronary atherosclerotic plaque activity measured using coronary F-sodium fluoride ( F-NaF) positron emission tomography (PET), and to determine whether F-NaF PET has prognostic value in both women and men. In a post-hoc analysis of observational cohort studies of patients with coronary atherosclerosis who had undergone F-NaF PET CT angiography, we compared the coronary microcalcification activity (CMA) in women and men. Baseline F-NaF PET CT angiography was available in 999 participants (151 (15%) women) with 4282 patient-years of follow-up. Compared to men, women had lower coronary calcium scores (116 [interquartile range, 27-434] versus 205 [51-571] Agatston units; p = 0.002) and CMA values (0.0 [0.0-1.12] versus 0.53 [0.0-2.54], p = 0.01). Following matching for plaque burden by coronary calcium scores and clinical comorbidities, there was no sex-related difference in CMA values (0.0 [0.0-1.12] versus 0.0 [0.0-1.23], p = 0.21) and similar proportions of women and men had no F-NaF uptake (53.0% (n = 80) and 48.3% (n = 73); p = 0.42), or CMA values > 1.56 (21.8% (n = 33) and 21.8% (n = 33); p = 1.00). Over a median follow-up of 4.5 [4.0-6.0] years, myocardial infarction occurred in 6.6% of women (n = 10) and 7.8% of men (n = 66). Coronary microcalcification activity greater than 0 was associated with a similarly increased risk of myocardial infarction in both women (HR: 3.83; 95% CI:1.10-18.49; p = 0.04) and men (HR: 5.29; 95% CI:2.28-12.28; p < 0.001). Although men present with more coronary atherosclerotic plaque than women, increased plaque activity is a strong predictor of future myocardial infarction regardless of sex.</abstract><cop>Germany</cop><pmid>38926161</pmid></addata></record>
fulltext	fulltext
identifier	EISSN: 1619-7089
ispartof	European journal of nuclear medicine and molecular imaging, 2024-06
issn	1619-7089
language	eng
recordid	cdi_pubmed_primary_38926161
source	SpringerLink Journals - AutoHoldings
title	Sex differences in coronary atherosclerotic plaque activity using 18 F-sodium fluoride positron emission tomography
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A35%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex%20differences%20in%20coronary%20atherosclerotic%20plaque%20activity%20using%2018%20F-sodium%20fluoride%20positron%20emission%20tomography&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=Kwiecinski,%20Jacek&rft.date=2024-06-27&rft.eissn=1619-7089&rft_id=info:doi/&rft_dat=%3Cpubmed%3E38926161%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/38926161&rfr_iscdi=true