Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase

Methylation of cytosine 32 in the anticodon loop of tRNAs to 3-methylcytosine (m C) is crucial for cellular translation fidelity. Misregulation of the RNA methyltransferases setting this modification can cause aggressive cancers and metabolic disturbances. Here, we report the cryo-electron microscop...

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Veröffentlicht in:	Nature structural & molecular biology 2024-10, Vol.31 (10), p.1614
Hauptverfasser:	Throll, Philipp, G Dolce, Luciano, Rico-Lastres, Palma, Arnold, Katharina, Tengo, Laura, Basu, Shibom, Kaiser, Stefanie, Schneider, Robert, Kowalinski, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cryoelectron Microscopy Humans Methylation Methyltransferases - chemistry Methyltransferases - metabolism Models, Molecular Protein Binding RNA, Transfer - chemistry RNA, Transfer - metabolism Serine-tRNA Ligase - chemistry Serine-tRNA Ligase - metabolism tRNA Methyltransferases - chemistry tRNA Methyltransferases - metabolism
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