Design, synthesis, molecular docking and anti-proliferative activity of novel phenothiazine containing imidazo[1,2-]pyridine derivatives against MARK4 protein

A series of novel phenothiazine-containing imidazo[1,2- a ]pyridine derivatives were designed and synthesized under metal-free conditions in excellent yield. These derivatives were effectively transformed further into N -alkyl, sulfoxide, and sulfone derivatives. Derivatives were deployed against hu...

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Veröffentlicht in:	MedChemComm 2024-06, Vol.15 (6), p.1942-1958
Hauptverfasser:	Bhakta, Avijit, Mukhtar, Sayeed, Anwar, Saleha, Haider, Shaista, Alahmdi, Mohammed Issa, Parveen, Humaira, Alsharif, Meshari A, Wani, Mohmmad Younus, Chakrabarty, Anindita, Hassan, Md. Imtaiyaz, Ahmed, Naseem
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Chemical synthesis Cytotoxicity DNA damage Kinases Molecular docking Phenothiazine Protein A Proteins Pyridines Reactive oxygen species
Online-Zugang:	Volltext
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