Improving glycemic control by transitioning from the MiniMed TM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study
The effectiveness of a hybrid closed-loop (HCL) system in improving glycemic control is unclear in Japanese individuals. Therefore, we assessed the effect impact of the MiniMed 770G HCL system on glycemic control in this population. This prospective, single-center, 24-week observational study (regis...
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| Veröffentlicht in: | Endocrine journal 2024-10, Vol.71 (10), p.955 |
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| creator | Kubota, Satoshi Sato, Ai Hosokawa, Manami Okubo, Yosuke Takayama, Shohei Kaneko, Atsuko Shimada, Yasuho Asano, Yuki Sato, Yoshihiko Yamazaki, Masanori Komatsu, Mitsuhisa |
| description | The effectiveness of a hybrid closed-loop (HCL) system in improving glycemic control is unclear in Japanese individuals. Therefore, we assessed the effect impact of the MiniMed 770G HCL system on glycemic control in this population. This prospective, single-center, 24-week observational study (registration number: UMIN000047394) enrolled 23 individuals with type 1 diabetes mellitus using the Medtronic MiniMed 640G system. The primary endpoint was the improvement in time in the range of 70-180 mg/dL after transitioning to the MiniMed 770G HCL system. We observed an increase in time in range (from 64.1 [55.8-69.5] to 70.9 [67.1-74.4] %, interquartile range 25-75%, p < 0.001) and a decrease in glycated hemoglobin level (from 7.4 [7.0-7.9] to 7.1 [6.8-7.4] %, p = 0.003). There was a significant reduction in time above the range (181-250 mg/dL: 25.8 [20.9-28.6] to 19.5 [17.1-22.1] %, p < 0.001; >251 mg/dL: 8.7 [4.0-13.0] to 4.7 [3.6-9.1] %, p < 0.001). Time below the range remained unchanged (54-69 mg/dL: 1.8 [0.4-2.4] to 2.1 [0.4-3.9] %, p = 0.24; |
| doi_str_mv | 10.1507/endocrj.EJ24-0136 |
| format | Article |
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Therefore, we assessed the effect impact of the MiniMed 770G HCL system on glycemic control in this population. This prospective, single-center, 24-week observational study (registration number: UMIN000047394) enrolled 23 individuals with type 1 diabetes mellitus using the Medtronic MiniMed 640G system. The primary endpoint was the improvement in time in the range of 70-180 mg/dL after transitioning to the MiniMed 770G HCL system. We observed an increase in time in range (from 64.1 [55.8-69.5] to 70.9 [67.1-74.4] %, interquartile range 25-75%, p < 0.001) and a decrease in glycated hemoglobin level (from 7.4 [7.0-7.9] to 7.1 [6.8-7.4] %, p = 0.003). There was a significant reduction in time above the range (181-250 mg/dL: 25.8 [20.9-28.6] to 19.5 [17.1-22.1] %, p < 0.001; >251 mg/dL: 8.7 [4.0-13.0] to 4.7 [3.6-9.1] %, p < 0.001). Time below the range remained unchanged (54-69 mg/dL: 1.8 [0.4-2.4] to 2.1 [0.4-3.9] %, p = 0.24; <54 mg/dL: 0.2 [0.0-1.0] to 0.5 [0.1-1.3] %, p = 0.14). In a subgroup of 12 patients with a high HCL implementation rate, the basal insulin infusion decreased immediately after mealtime insulin administration and increased after approximately 120 minutes. The ratings from questionnaires assessing treatment burden, satisfaction, and quality of life remained unchanged. The MiniMed 770G HCL system improved glycemic control and optimized insulin delivery, particularly in patients with high implementation rates.</description><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.EJ24-0136</identifier><identifier>PMID: 38897943</identifier><language>eng</language><publisher>Japan</publisher><subject>Adult ; Blood Glucose ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; East Asian People ; Female ; Glycated Hemoglobin ; Glycemic Control - instrumentation ; Glycemic Control - methods ; Humans ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - therapeutic use ; Insulin - administration & dosage ; Insulin - therapeutic use ; Insulin Infusion Systems ; Japan ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome</subject><ispartof>Endocrine journal, 2024-10, Vol.71 (10), p.955</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1359-9732</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38897943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kubota, Satoshi</creatorcontrib><creatorcontrib>Sato, Ai</creatorcontrib><creatorcontrib>Hosokawa, Manami</creatorcontrib><creatorcontrib>Okubo, Yosuke</creatorcontrib><creatorcontrib>Takayama, Shohei</creatorcontrib><creatorcontrib>Kaneko, Atsuko</creatorcontrib><creatorcontrib>Shimada, Yasuho</creatorcontrib><creatorcontrib>Asano, Yuki</creatorcontrib><creatorcontrib>Sato, Yoshihiko</creatorcontrib><creatorcontrib>Yamazaki, Masanori</creatorcontrib><creatorcontrib>Komatsu, Mitsuhisa</creatorcontrib><title>Improving glycemic control by transitioning from the MiniMed TM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study</title><title>Endocrine journal</title><addtitle>Endocr J</addtitle><description>The effectiveness of a hybrid closed-loop (HCL) system in improving glycemic control is unclear in Japanese individuals. Therefore, we assessed the effect impact of the MiniMed 770G HCL system on glycemic control in this population. This prospective, single-center, 24-week observational study (registration number: UMIN000047394) enrolled 23 individuals with type 1 diabetes mellitus using the Medtronic MiniMed 640G system. The primary endpoint was the improvement in time in the range of 70-180 mg/dL after transitioning to the MiniMed 770G HCL system. We observed an increase in time in range (from 64.1 [55.8-69.5] to 70.9 [67.1-74.4] %, interquartile range 25-75%, p < 0.001) and a decrease in glycated hemoglobin level (from 7.4 [7.0-7.9] to 7.1 [6.8-7.4] %, p = 0.003). There was a significant reduction in time above the range (181-250 mg/dL: 25.8 [20.9-28.6] to 19.5 [17.1-22.1] %, p < 0.001; >251 mg/dL: 8.7 [4.0-13.0] to 4.7 [3.6-9.1] %, p < 0.001). Time below the range remained unchanged (54-69 mg/dL: 1.8 [0.4-2.4] to 2.1 [0.4-3.9] %, p = 0.24; <54 mg/dL: 0.2 [0.0-1.0] to 0.5 [0.1-1.3] %, p = 0.14). In a subgroup of 12 patients with a high HCL implementation rate, the basal insulin infusion decreased immediately after mealtime insulin administration and increased after approximately 120 minutes. The ratings from questionnaires assessing treatment burden, satisfaction, and quality of life remained unchanged. The MiniMed 770G HCL system improved glycemic control and optimized insulin delivery, particularly in patients with high implementation rates.</description><subject>Adult</subject><subject>Blood Glucose</subject><subject>Blood Glucose Self-Monitoring</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>East Asian People</subject><subject>Female</subject><subject>Glycated Hemoglobin</subject><subject>Glycemic Control - instrumentation</subject><subject>Glycemic Control - methods</subject><subject>Humans</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - therapeutic use</subject><subject>Insulin Infusion Systems</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Treatment Outcome</subject><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtOwzAURS0kxH8BTNBbQAN27Do2M1SVT9WKSefIcZ6pq8SJbLcou2KJtAJGZ3J0j3QJuWX0nk1p9YCh6W3c3s8XpSgo4_KEXDAuVCGmgp6Ty5S2lHI-FfyMnHOldKUFvyDfb90Q-70Pn_DZjhY7b8H2Ice-hXqEHE1IPvs-HA0X-w7yBmHlg19hA-sVSEFfIPdQVQf6AAszmIAJwTS7Nif48nkDeRwQGDTe1JgxQYdt6_MuPYKBQz4NaLPf4wTSIdNiYTFkjBPo64Rxb45900LKu2a8JqfOtAlv_nhF1s_z9ey1WL6_vM2elsUgpSyqkjqnsTG6klwJplBqJ2mppNbaGiGMYowby6alMM41lbDUoas01qpUyvErcvc7O-zqDpuPIfrOxPHj_zn-A-iQcqo</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Kubota, Satoshi</creator><creator>Sato, Ai</creator><creator>Hosokawa, Manami</creator><creator>Okubo, Yosuke</creator><creator>Takayama, Shohei</creator><creator>Kaneko, Atsuko</creator><creator>Shimada, Yasuho</creator><creator>Asano, Yuki</creator><creator>Sato, Yoshihiko</creator><creator>Yamazaki, Masanori</creator><creator>Komatsu, Mitsuhisa</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-1359-9732</orcidid></search><sort><creationdate>20241001</creationdate><title>Improving glycemic control by transitioning from the MiniMed TM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study</title><author>Kubota, Satoshi ; Sato, Ai ; Hosokawa, Manami ; Okubo, Yosuke ; Takayama, Shohei ; Kaneko, Atsuko ; Shimada, Yasuho ; Asano, Yuki ; Sato, Yoshihiko ; Yamazaki, Masanori ; Komatsu, Mitsuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p666-720ff9eda97638418e69f60286999ca44a8113ac1524affd74c0fef79eb8288f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Blood Glucose</topic><topic>Blood Glucose Self-Monitoring</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>East Asian People</topic><topic>Female</topic><topic>Glycated Hemoglobin</topic><topic>Glycemic Control - instrumentation</topic><topic>Glycemic Control - methods</topic><topic>Humans</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - therapeutic use</topic><topic>Insulin Infusion Systems</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubota, Satoshi</creatorcontrib><creatorcontrib>Sato, Ai</creatorcontrib><creatorcontrib>Hosokawa, Manami</creatorcontrib><creatorcontrib>Okubo, Yosuke</creatorcontrib><creatorcontrib>Takayama, Shohei</creatorcontrib><creatorcontrib>Kaneko, Atsuko</creatorcontrib><creatorcontrib>Shimada, Yasuho</creatorcontrib><creatorcontrib>Asano, Yuki</creatorcontrib><creatorcontrib>Sato, Yoshihiko</creatorcontrib><creatorcontrib>Yamazaki, Masanori</creatorcontrib><creatorcontrib>Komatsu, Mitsuhisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Endocrine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubota, Satoshi</au><au>Sato, Ai</au><au>Hosokawa, Manami</au><au>Okubo, Yosuke</au><au>Takayama, Shohei</au><au>Kaneko, Atsuko</au><au>Shimada, Yasuho</au><au>Asano, Yuki</au><au>Sato, Yoshihiko</au><au>Yamazaki, Masanori</au><au>Komatsu, Mitsuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improving glycemic control by transitioning from the MiniMed TM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study</atitle><jtitle>Endocrine journal</jtitle><addtitle>Endocr J</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>71</volume><issue>10</issue><spage>955</spage><pages>955-</pages><eissn>1348-4540</eissn><abstract>The effectiveness of a hybrid closed-loop (HCL) system in improving glycemic control is unclear in Japanese individuals. Therefore, we assessed the effect impact of the MiniMed 770G HCL system on glycemic control in this population. This prospective, single-center, 24-week observational study (registration number: UMIN000047394) enrolled 23 individuals with type 1 diabetes mellitus using the Medtronic MiniMed 640G system. The primary endpoint was the improvement in time in the range of 70-180 mg/dL after transitioning to the MiniMed 770G HCL system. We observed an increase in time in range (from 64.1 [55.8-69.5] to 70.9 [67.1-74.4] %, interquartile range 25-75%, p < 0.001) and a decrease in glycated hemoglobin level (from 7.4 [7.0-7.9] to 7.1 [6.8-7.4] %, p = 0.003). There was a significant reduction in time above the range (181-250 mg/dL: 25.8 [20.9-28.6] to 19.5 [17.1-22.1] %, p < 0.001; >251 mg/dL: 8.7 [4.0-13.0] to 4.7 [3.6-9.1] %, p < 0.001). Time below the range remained unchanged (54-69 mg/dL: 1.8 [0.4-2.4] to 2.1 [0.4-3.9] %, p = 0.24; <54 mg/dL: 0.2 [0.0-1.0] to 0.5 [0.1-1.3] %, p = 0.14). In a subgroup of 12 patients with a high HCL implementation rate, the basal insulin infusion decreased immediately after mealtime insulin administration and increased after approximately 120 minutes. The ratings from questionnaires assessing treatment burden, satisfaction, and quality of life remained unchanged. The MiniMed 770G HCL system improved glycemic control and optimized insulin delivery, particularly in patients with high implementation rates.</abstract><cop>Japan</cop><pmid>38897943</pmid><doi>10.1507/endocrj.EJ24-0136</doi><orcidid>https://orcid.org/0000-0002-1359-9732</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Endocrine journal, 2024-10, Vol.71 (10), p.955 |
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| subjects | Adult Blood Glucose Blood Glucose Self-Monitoring Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy East Asian People Female Glycated Hemoglobin Glycemic Control - instrumentation Glycemic Control - methods Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Insulin - administration & dosage Insulin - therapeutic use Insulin Infusion Systems Japan Male Middle Aged Prospective Studies Treatment Outcome |
| title | Improving glycemic control by transitioning from the MiniMed TM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study |
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