Aztreonam Versus Gentamicin, Each With Clindamycin, in the Treatment of Endometritis
A randomized comparison of aztreonam (2 g intravenously every eight hours) versus gentamicin (1.5 mg/kg intravenously every eight hours), each with clindamycin (600 mg intravenously every six hours), was performed in 119 patients with endometritis after cesarean section. Patients in both groups had...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1985-06, Vol.65 (6), p.825-829 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | GIBBS, RONALD S BLANCO, JORGE D LIPSCOMB, KATHLEEN A ST CLAIR, PATRICIA J |
| description | A randomized comparison of aztreonam (2 g intravenously every eight hours) versus gentamicin (1.5 mg/kg intravenously every eight hours), each with clindamycin (600 mg intravenously every six hours), was performed in 119 patients with endometritis after cesarean section. Patients in both groups had similar risk factors. Genital cultures revealed an average of 3.0 isolates per specimen. Eighty-five aerobic gram-negative rods were isolated from 57 (48%) patients. All were susceptible to both aztreonam and gentamicin. Of 133 anaerobic isolates, 131 (98%) were susceptible to clindamycin. The failures in the aztreonam group were associated with a wound abscess and with an enterococcal bacteremia. Of the six failures in the gentamicin group, two were associated with persistent isolation of enteric bacilli. In the other four failures, no explanation was evident. Side effects occurred in four patients, (three diarrhea, one allergic reaction). All were self-limited and appeared to be due to clindamycin. No patient showed nephrotoxicity. When used in combination with clindamycin, aztreonam gave clinical results similar to gentamicin. |
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Patients in both groups had similar risk factors. Genital cultures revealed an average of 3.0 isolates per specimen. Eighty-five aerobic gram-negative rods were isolated from 57 (48%) patients. All were susceptible to both aztreonam and gentamicin. Of 133 anaerobic isolates, 131 (98%) were susceptible to clindamycin. The failures in the aztreonam group were associated with a wound abscess and with an enterococcal bacteremia. Of the six failures in the gentamicin group, two were associated with persistent isolation of enteric bacilli. In the other four failures, no explanation was evident. Side effects occurred in four patients, (three diarrhea, one allergic reaction). All were self-limited and appeared to be due to clindamycin. No patient showed nephrotoxicity. When used in combination with clindamycin, aztreonam gave clinical results similar to gentamicin.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 3889748</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adult ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Aztreonam ; Biological and medical sciences ; Cesarean Section ; Clindamycin - administration & dosage ; Clindamycin - pharmacology ; Clinical Trials as Topic ; Drug Resistance, Microbial ; Drug Therapy, Combination ; Endometritis - drug therapy ; Endometritis - etiology ; Endometritis - microbiology ; Enterobacteriaceae - drug effects ; Enterobacteriaceae - isolation & purification ; Female ; Gentamicins - administration & dosage ; Gentamicins - pharmacology ; Gram-Negative Aerobic Bacteria - drug effects ; Gram-Negative Aerobic Bacteria - isolation & purification ; Humans ; Medical sciences ; Pharmacology. Drug treatments ; Postoperative Complications ; Pregnancy ; Random Allocation</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1985-06, Vol.65 (6), p.825-829</ispartof><rights>1985 The American College of Obstetricians and Gynecologists</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8482846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3889748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GIBBS, RONALD S</creatorcontrib><creatorcontrib>BLANCO, JORGE D</creatorcontrib><creatorcontrib>LIPSCOMB, KATHLEEN A</creatorcontrib><creatorcontrib>ST CLAIR, PATRICIA J</creatorcontrib><title>Aztreonam Versus Gentamicin, Each With Clindamycin, in the Treatment of Endometritis</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>A randomized comparison of aztreonam (2 g intravenously every eight hours) versus gentamicin (1.5 mg/kg intravenously every eight hours), each with clindamycin (600 mg intravenously every six hours), was performed in 119 patients with endometritis after cesarean section. Patients in both groups had similar risk factors. Genital cultures revealed an average of 3.0 isolates per specimen. Eighty-five aerobic gram-negative rods were isolated from 57 (48%) patients. All were susceptible to both aztreonam and gentamicin. Of 133 anaerobic isolates, 131 (98%) were susceptible to clindamycin. The failures in the aztreonam group were associated with a wound abscess and with an enterococcal bacteremia. Of the six failures in the gentamicin group, two were associated with persistent isolation of enteric bacilli. In the other four failures, no explanation was evident. Side effects occurred in four patients, (three diarrhea, one allergic reaction). All were self-limited and appeared to be due to clindamycin. No patient showed nephrotoxicity. When used in combination with clindamycin, aztreonam gave clinical results similar to gentamicin.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Aztreonam</subject><subject>Biological and medical sciences</subject><subject>Cesarean Section</subject><subject>Clindamycin - administration & dosage</subject><subject>Clindamycin - pharmacology</subject><subject>Clinical Trials as Topic</subject><subject>Drug Resistance, Microbial</subject><subject>Drug Therapy, Combination</subject><subject>Endometritis - drug therapy</subject><subject>Endometritis - etiology</subject><subject>Endometritis - microbiology</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae - isolation & purification</subject><subject>Female</subject><subject>Gentamicins - administration & dosage</subject><subject>Gentamicins - pharmacology</subject><subject>Gram-Negative Aerobic Bacteria - drug effects</subject><subject>Gram-Negative Aerobic Bacteria - isolation & purification</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications</subject><subject>Pregnancy</subject><subject>Random Allocation</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotVZ_gpCDRxeySXY3OZZSW6HgpX7cltnsLBvdj5KklPrrjbZ4Gmbeh5l33gsyTVUhEi7ExyWZMsZ1Uigpr8mN95-MsTTXYkImQildSDUl2_l3cDgO0NM3dH7v6QqHAL01dnikSzAtfbehpYvODjX0x7-xHWhokW4dQugjTseGLod67DE4G6y_JVcNdB7vznVGXp-W28U62bysnhfzTbLjiqWJLlKTVbWIlipQqqmErrBCYSQaqBXXIAXLMs4bhcYUgIVqQPIGWM7rWoOYkfvT3t2-6rEud8724I7l-buoP5x18Aa6xsFgrP_HlFRcyTxi8oQdxi7EEL66_QFd2SJ0oS1jaPFexpJUq4zlsUt-c0zFD4lKadA</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>GIBBS, RONALD S</creator><creator>BLANCO, JORGE D</creator><creator>LIPSCOMB, KATHLEEN A</creator><creator>ST CLAIR, PATRICIA J</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198506</creationdate><title>Aztreonam Versus Gentamicin, Each With Clindamycin, in the Treatment of Endometritis</title><author>GIBBS, RONALD S ; BLANCO, JORGE D ; LIPSCOMB, KATHLEEN A ; ST CLAIR, PATRICIA J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2801-971c5bd3693ba88fb39bebe3c4ecad829a4305522f8ecc7ae78fa42fa062dd9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Aztreonam</topic><topic>Biological and medical sciences</topic><topic>Cesarean Section</topic><topic>Clindamycin - administration & dosage</topic><topic>Clindamycin - pharmacology</topic><topic>Clinical Trials as Topic</topic><topic>Drug Resistance, Microbial</topic><topic>Drug Therapy, Combination</topic><topic>Endometritis - drug therapy</topic><topic>Endometritis - etiology</topic><topic>Endometritis - microbiology</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Enterobacteriaceae - isolation & purification</topic><topic>Female</topic><topic>Gentamicins - administration & dosage</topic><topic>Gentamicins - pharmacology</topic><topic>Gram-Negative Aerobic Bacteria - drug effects</topic><topic>Gram-Negative Aerobic Bacteria - isolation & purification</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications</topic><topic>Pregnancy</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GIBBS, RONALD S</creatorcontrib><creatorcontrib>BLANCO, JORGE D</creatorcontrib><creatorcontrib>LIPSCOMB, KATHLEEN A</creatorcontrib><creatorcontrib>ST CLAIR, PATRICIA J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GIBBS, RONALD S</au><au>BLANCO, JORGE D</au><au>LIPSCOMB, KATHLEEN A</au><au>ST CLAIR, PATRICIA J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aztreonam Versus Gentamicin, Each With Clindamycin, in the Treatment of Endometritis</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1985-06</date><risdate>1985</risdate><volume>65</volume><issue>6</issue><spage>825</spage><epage>829</epage><pages>825-829</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>A randomized comparison of aztreonam (2 g intravenously every eight hours) versus gentamicin (1.5 mg/kg intravenously every eight hours), each with clindamycin (600 mg intravenously every six hours), was performed in 119 patients with endometritis after cesarean section. Patients in both groups had similar risk factors. Genital cultures revealed an average of 3.0 isolates per specimen. Eighty-five aerobic gram-negative rods were isolated from 57 (48%) patients. All were susceptible to both aztreonam and gentamicin. Of 133 anaerobic isolates, 131 (98%) were susceptible to clindamycin. The failures in the aztreonam group were associated with a wound abscess and with an enterococcal bacteremia. Of the six failures in the gentamicin group, two were associated with persistent isolation of enteric bacilli. In the other four failures, no explanation was evident. Side effects occurred in four patients, (three diarrhea, one allergic reaction). All were self-limited and appeared to be due to clindamycin. No patient showed nephrotoxicity. When used in combination with clindamycin, aztreonam gave clinical results similar to gentamicin.</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>3889748</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 1985-06, Vol.65 (6), p.825-829 |
| issn | 0029-7844 1873-233X |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Aztreonam Biological and medical sciences Cesarean Section Clindamycin - administration & dosage Clindamycin - pharmacology Clinical Trials as Topic Drug Resistance, Microbial Drug Therapy, Combination Endometritis - drug therapy Endometritis - etiology Endometritis - microbiology Enterobacteriaceae - drug effects Enterobacteriaceae - isolation & purification Female Gentamicins - administration & dosage Gentamicins - pharmacology Gram-Negative Aerobic Bacteria - drug effects Gram-Negative Aerobic Bacteria - isolation & purification Humans Medical sciences Pharmacology. Drug treatments Postoperative Complications Pregnancy Random Allocation |
| title | Aztreonam Versus Gentamicin, Each With Clindamycin, in the Treatment of Endometritis |
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