Modular synthesis of cyclic β-difluoroamines

Fluorine-containing saturated nitrogen heterocycles are very attractive structures in medicinal and biological chemistry because fluorine can be used to tune conformation as well as key properties such as basicity and bioavailability. At present cyclic fluorinated amines are accessed using hazardous...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2024-07, Vol.6 (6), p.771-774
Hauptverfasser:	Charlesworth, Natalie G, Arunprasath, Dhanarajan, Graham, Mark A, Argent, Stephen P, Datsenko, Oleksandr P, Mykhailiuk, Pavel K, Denton, Ross M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Basicity Bioavailability Biological properties Chemical synthesis Fluorine Hydrogen atoms Modular structures Photoredox catalysis Reagents
Online-Zugang:	Volltext
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