Modulation of toxic effects of ammonia on growth, pathology of liver and kidney tissues and relative expression of GH and IGF-1 Genes by CoQ 10 Supplementation in Oncorhynchus mykiss
Reducing the negative impact of environmental and stressful factors is a crucial step in achieving sustainable aquaculture. Therefore, a study was aimed at evaluating the impacts of Coenzyme Q (CoQ ) supplementation on growth, relative gene expression of Growth Hormone (GH) and Insulin-like growth f...
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| Veröffentlicht in: | Fish physiology and biochemistry 2024-08, Vol.50 (4), p.1711 |
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| container_title | Fish physiology and biochemistry |
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| creator | Zargari, Ashkan Mazandarani, Mohammad Safari, Roghieh Hoseinifar, Hossein Hedayati, Aliakbar |
| description | Reducing the negative impact of environmental and stressful factors is a crucial step in achieving sustainable aquaculture. Therefore, a study was aimed at evaluating the impacts of Coenzyme Q
(CoQ
) supplementation on growth, relative gene expression of Growth Hormone (GH) and Insulin-like growth factor-1 (IGF-1), liver and kidney histopathology against stress induced by ammonia in Rainbow trout (Oncorhynchus mykiss). The fish were given feed containing different levels of CoQ
for 8 weeks: Control - CoQ
0%, G1 - CoQ
0.1%, G2 - CoQ
0.5% and G3 - CoQ
1%. At the end of the experiment, fish were exposed to ammonia stress concentration at 0.6mg/L for 24 h to assess liver and kidney tissue damage. Results showed that there was a significant activity increase in GH and IGF-1 genes due to supplementation with CoQ
alone (p |
| format | Article |
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(CoQ
) supplementation on growth, relative gene expression of Growth Hormone (GH) and Insulin-like growth factor-1 (IGF-1), liver and kidney histopathology against stress induced by ammonia in Rainbow trout (Oncorhynchus mykiss). The fish were given feed containing different levels of CoQ
for 8 weeks: Control - CoQ
0%, G1 - CoQ
0.1%, G2 - CoQ
0.5% and G3 - CoQ
1%. At the end of the experiment, fish were exposed to ammonia stress concentration at 0.6mg/L for 24 h to assess liver and kidney tissue damage. Results showed that there was a significant activity increase in GH and IGF-1 genes due to supplementation with CoQ
alone (p < 0.05). Gene expression for GH increased about two-fold whereas that for IGF-1 experienced a four-fold upregulation compared to controls (p < 0.05). CoQ
's-related antioxidant effects probably minimized liver and kidney cellular injuries, as significant decreases were observed in ammonia-induced mortality (p < 0.05). In summary, adding CoQ
to the diet is a potential way to improve fish production through controlling the gene expression of GH and IGF-1, as well as making fish populations more resistant to possible future stress caused by ammonia in intensive or super-intensive aquaculture systems.</description><identifier>EISSN: 1573-5168</identifier><identifier>PMID: 38878123</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Ammonia - toxicity ; Animal Feed - analysis ; Animals ; Diet - veterinary ; Dietary Supplements ; Growth Hormone - genetics ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor I - metabolism ; Kidney - drug effects ; Liver - drug effects ; Liver - metabolism ; Oncorhynchus mykiss - genetics ; Ubiquinone - analogs & derivatives ; Ubiquinone - pharmacology</subject><ispartof>Fish physiology and biochemistry, 2024-08, Vol.50 (4), p.1711</ispartof><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38878123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zargari, Ashkan</creatorcontrib><creatorcontrib>Mazandarani, Mohammad</creatorcontrib><creatorcontrib>Safari, Roghieh</creatorcontrib><creatorcontrib>Hoseinifar, Hossein</creatorcontrib><creatorcontrib>Hedayati, Aliakbar</creatorcontrib><title>Modulation of toxic effects of ammonia on growth, pathology of liver and kidney tissues and relative expression of GH and IGF-1 Genes by CoQ 10 Supplementation in Oncorhynchus mykiss</title><title>Fish physiology and biochemistry</title><addtitle>Fish Physiol Biochem</addtitle><description>Reducing the negative impact of environmental and stressful factors is a crucial step in achieving sustainable aquaculture. Therefore, a study was aimed at evaluating the impacts of Coenzyme Q
(CoQ
) supplementation on growth, relative gene expression of Growth Hormone (GH) and Insulin-like growth factor-1 (IGF-1), liver and kidney histopathology against stress induced by ammonia in Rainbow trout (Oncorhynchus mykiss). The fish were given feed containing different levels of CoQ
for 8 weeks: Control - CoQ
0%, G1 - CoQ
0.1%, G2 - CoQ
0.5% and G3 - CoQ
1%. At the end of the experiment, fish were exposed to ammonia stress concentration at 0.6mg/L for 24 h to assess liver and kidney tissue damage. Results showed that there was a significant activity increase in GH and IGF-1 genes due to supplementation with CoQ
alone (p < 0.05). Gene expression for GH increased about two-fold whereas that for IGF-1 experienced a four-fold upregulation compared to controls (p < 0.05). CoQ
's-related antioxidant effects probably minimized liver and kidney cellular injuries, as significant decreases were observed in ammonia-induced mortality (p < 0.05). In summary, adding CoQ
to the diet is a potential way to improve fish production through controlling the gene expression of GH and IGF-1, as well as making fish populations more resistant to possible future stress caused by ammonia in intensive or super-intensive aquaculture systems.</description><subject>Ammonia - toxicity</subject><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Diet - veterinary</subject><subject>Dietary Supplements</subject><subject>Growth Hormone - genetics</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Kidney - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Oncorhynchus mykiss - genetics</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Ubiquinone - pharmacology</subject><issn>1573-5168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFj81OwzAQhC0kRMvPK6B9ACLFRG3CuaIpB4QquFdusmlM_SevXeoX4_lISjlzGmm-0c7sBZvyWVlkMz6vJuya6DPP86dyzq_YpKiqsuKPxZR9v9o2KhGkNWA7CPYoG8CuwybQaAitrZECBrzz9iv0D-BE6K2yuzRyJQ_oQZgW9rI1mCBIooh0sjyOlw8IeHQeic4l9epEX-plxqFGM6S3CRZ2DTyH9-icQo0m_I6SBt5MY32fTNNHAp32Q8Mtu-yEIrw76w27Xz5_LFaZi1uN7cZ5qYVPm79Hi38DP4OQYQ4</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Zargari, Ashkan</creator><creator>Mazandarani, Mohammad</creator><creator>Safari, Roghieh</creator><creator>Hoseinifar, Hossein</creator><creator>Hedayati, Aliakbar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202408</creationdate><title>Modulation of toxic effects of ammonia on growth, pathology of liver and kidney tissues and relative expression of GH and IGF-1 Genes by CoQ 10 Supplementation in Oncorhynchus mykiss</title><author>Zargari, Ashkan ; Mazandarani, Mohammad ; Safari, Roghieh ; Hoseinifar, Hossein ; Hedayati, Aliakbar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_388781233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ammonia - toxicity</topic><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Diet - veterinary</topic><topic>Dietary Supplements</topic><topic>Growth Hormone - genetics</topic><topic>Insulin-Like Growth Factor I - genetics</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Kidney - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Oncorhynchus mykiss - genetics</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Ubiquinone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zargari, Ashkan</creatorcontrib><creatorcontrib>Mazandarani, Mohammad</creatorcontrib><creatorcontrib>Safari, Roghieh</creatorcontrib><creatorcontrib>Hoseinifar, Hossein</creatorcontrib><creatorcontrib>Hedayati, Aliakbar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Fish physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zargari, Ashkan</au><au>Mazandarani, Mohammad</au><au>Safari, Roghieh</au><au>Hoseinifar, Hossein</au><au>Hedayati, Aliakbar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of toxic effects of ammonia on growth, pathology of liver and kidney tissues and relative expression of GH and IGF-1 Genes by CoQ 10 Supplementation in Oncorhynchus mykiss</atitle><jtitle>Fish physiology and biochemistry</jtitle><addtitle>Fish Physiol Biochem</addtitle><date>2024-08</date><risdate>2024</risdate><volume>50</volume><issue>4</issue><spage>1711</spage><pages>1711-</pages><eissn>1573-5168</eissn><abstract>Reducing the negative impact of environmental and stressful factors is a crucial step in achieving sustainable aquaculture. Therefore, a study was aimed at evaluating the impacts of Coenzyme Q
(CoQ
) supplementation on growth, relative gene expression of Growth Hormone (GH) and Insulin-like growth factor-1 (IGF-1), liver and kidney histopathology against stress induced by ammonia in Rainbow trout (Oncorhynchus mykiss). The fish were given feed containing different levels of CoQ
for 8 weeks: Control - CoQ
0%, G1 - CoQ
0.1%, G2 - CoQ
0.5% and G3 - CoQ
1%. At the end of the experiment, fish were exposed to ammonia stress concentration at 0.6mg/L for 24 h to assess liver and kidney tissue damage. Results showed that there was a significant activity increase in GH and IGF-1 genes due to supplementation with CoQ
alone (p < 0.05). Gene expression for GH increased about two-fold whereas that for IGF-1 experienced a four-fold upregulation compared to controls (p < 0.05). CoQ
's-related antioxidant effects probably minimized liver and kidney cellular injuries, as significant decreases were observed in ammonia-induced mortality (p < 0.05). In summary, adding CoQ
to the diet is a potential way to improve fish production through controlling the gene expression of GH and IGF-1, as well as making fish populations more resistant to possible future stress caused by ammonia in intensive or super-intensive aquaculture systems.</abstract><cop>Netherlands</cop><pmid>38878123</pmid></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1573-5168 |
| ispartof | Fish physiology and biochemistry, 2024-08, Vol.50 (4), p.1711 |
| issn | 1573-5168 |
| language | eng |
| recordid | cdi_pubmed_primary_38878123 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Ammonia - toxicity Animal Feed - analysis Animals Diet - veterinary Dietary Supplements Growth Hormone - genetics Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Kidney - drug effects Liver - drug effects Liver - metabolism Oncorhynchus mykiss - genetics Ubiquinone - analogs & derivatives Ubiquinone - pharmacology |
| title | Modulation of toxic effects of ammonia on growth, pathology of liver and kidney tissues and relative expression of GH and IGF-1 Genes by CoQ 10 Supplementation in Oncorhynchus mykiss |
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