Delayed diagnosis of osteosarcoma in adults: a prognostic factor to be considered
different variables have been associated with a worse prognosis of patients with osteosarcoma (OS), highlighting tumor size, location in the axial skeleton and the presence of metastases. The objective of this study is to analyze the prognostic impact of diagnostic delay in osteosarcoma in adults in...
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| Veröffentlicht in: | Acta ortopédica mexicana 2024-05, Vol.38 (3), p.164 |
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| creator | Clara-Altamirano, M A García-Ortega, D Y Álvarez-Cano, A Velázquez-Rodríguez, S Lizcano-Suárez, A R Rosas, L C Uribe-Saloma, C E Martínez-Said, H Villavicencio-Valencia, V Cuellar-Hubbe, M |
| description | different variables have been associated with a worse prognosis of patients with osteosarcoma (OS), highlighting tumor size, location in the axial skeleton and the presence of metastases. The objective of this study is to analyze the prognostic impact of diagnostic delay in osteosarcoma in adults in the Mexican population in a center specialized in sarcomas.
retrospective cohort study from January 1, 2005, to December 31, 2016, 96 patients over 21 years of age with a diagnosis of osteosarcoma were analyzed.
the median time to diagnosis from the onset of symptoms was six months (range: 2-36). This variable was dichotomized by applying the operator-dependent curve (ROC) analysis and we determined a cut-off value greater than five months, with an area under the curve (AUC) = 0.93 [95% CI 0.86-0.97], sensitivity 93.2% and specificity 94.6%.
time until diagnosis is a critical factor in the survival of adult patients with osteosarcoma, highlighting its influence on disease progression and the appearance of metastasis. The correlation between diagnostic delay and an unfavorable prognosis reinforces the need for rapid and efficient evaluation in suspected cases of osteosarcoma. |
| doi_str_mv | 10.35366/115811 |
| format | Article |
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retrospective cohort study from January 1, 2005, to December 31, 2016, 96 patients over 21 years of age with a diagnosis of osteosarcoma were analyzed.
the median time to diagnosis from the onset of symptoms was six months (range: 2-36). This variable was dichotomized by applying the operator-dependent curve (ROC) analysis and we determined a cut-off value greater than five months, with an area under the curve (AUC) = 0.93 [95% CI 0.86-0.97], sensitivity 93.2% and specificity 94.6%.
time until diagnosis is a critical factor in the survival of adult patients with osteosarcoma, highlighting its influence on disease progression and the appearance of metastasis. The correlation between diagnostic delay and an unfavorable prognosis reinforces the need for rapid and efficient evaluation in suspected cases of osteosarcoma.</description><identifier>ISSN: 2306-4102</identifier><identifier>DOI: 10.35366/115811</identifier><identifier>PMID: 38862146</identifier><language>spa</language><publisher>Mexico</publisher><subject>Adult ; Aged ; Bone Neoplasms - diagnosis ; Bone Neoplasms - pathology ; Cohort Studies ; Delayed Diagnosis ; Disease Progression ; Female ; Humans ; Male ; Mexico ; Middle Aged ; Osteosarcoma - diagnosis ; Osteosarcoma - mortality ; Osteosarcoma - pathology ; Prognosis ; Retrospective Studies ; ROC Curve ; Sensitivity and Specificity ; Time Factors ; Young Adult</subject><ispartof>Acta ortopédica mexicana, 2024-05, Vol.38 (3), p.164</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38862146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clara-Altamirano, M A</creatorcontrib><creatorcontrib>García-Ortega, D Y</creatorcontrib><creatorcontrib>Álvarez-Cano, A</creatorcontrib><creatorcontrib>Velázquez-Rodríguez, S</creatorcontrib><creatorcontrib>Lizcano-Suárez, A R</creatorcontrib><creatorcontrib>Rosas, L C</creatorcontrib><creatorcontrib>Uribe-Saloma, C E</creatorcontrib><creatorcontrib>Martínez-Said, H</creatorcontrib><creatorcontrib>Villavicencio-Valencia, V</creatorcontrib><creatorcontrib>Cuellar-Hubbe, M</creatorcontrib><title>Delayed diagnosis of osteosarcoma in adults: a prognostic factor to be considered</title><title>Acta ortopédica mexicana</title><addtitle>Acta Ortop Mex</addtitle><description>different variables have been associated with a worse prognosis of patients with osteosarcoma (OS), highlighting tumor size, location in the axial skeleton and the presence of metastases. The objective of this study is to analyze the prognostic impact of diagnostic delay in osteosarcoma in adults in the Mexican population in a center specialized in sarcomas.
retrospective cohort study from January 1, 2005, to December 31, 2016, 96 patients over 21 years of age with a diagnosis of osteosarcoma were analyzed.
the median time to diagnosis from the onset of symptoms was six months (range: 2-36). This variable was dichotomized by applying the operator-dependent curve (ROC) analysis and we determined a cut-off value greater than five months, with an area under the curve (AUC) = 0.93 [95% CI 0.86-0.97], sensitivity 93.2% and specificity 94.6%.
time until diagnosis is a critical factor in the survival of adult patients with osteosarcoma, highlighting its influence on disease progression and the appearance of metastasis. The correlation between diagnostic delay and an unfavorable prognosis reinforces the need for rapid and efficient evaluation in suspected cases of osteosarcoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Bone Neoplasms - diagnosis</subject><subject>Bone Neoplasms - pathology</subject><subject>Cohort Studies</subject><subject>Delayed Diagnosis</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>Osteosarcoma - diagnosis</subject><subject>Osteosarcoma - mortality</subject><subject>Osteosarcoma - pathology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>2306-4102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFzrsKwjAUgOEMivWGbyDnBdSkaUNx9YKr4C7HJpVI21Ny0qFvL4LOTv_yDb8QKyW3OtfG7JTKC6VGYppqaTaZkmkiZswvKfM8VXIiEl0UJlWZmYrr0dU4OAvW47Ml9gxUAXF0xBhKahB8C2j7OvIeELpAHxZ9CRWWkQJEgoeDklr21gVnF2JcYc1u-e1crM-n2-Gy6fpH4-y9C77BMNx_D_oveAODlz_X</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Clara-Altamirano, M A</creator><creator>García-Ortega, D Y</creator><creator>Álvarez-Cano, A</creator><creator>Velázquez-Rodríguez, S</creator><creator>Lizcano-Suárez, A R</creator><creator>Rosas, L C</creator><creator>Uribe-Saloma, C E</creator><creator>Martínez-Said, H</creator><creator>Villavicencio-Valencia, V</creator><creator>Cuellar-Hubbe, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202405</creationdate><title>Delayed diagnosis of osteosarcoma in adults: a prognostic factor to be considered</title><author>Clara-Altamirano, M A ; García-Ortega, D Y ; Álvarez-Cano, A ; Velázquez-Rodríguez, S ; Lizcano-Suárez, A R ; Rosas, L C ; Uribe-Saloma, C E ; Martínez-Said, H ; Villavicencio-Valencia, V ; Cuellar-Hubbe, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_388621463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bone Neoplasms - diagnosis</topic><topic>Bone Neoplasms - pathology</topic><topic>Cohort Studies</topic><topic>Delayed Diagnosis</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mexico</topic><topic>Middle Aged</topic><topic>Osteosarcoma - diagnosis</topic><topic>Osteosarcoma - mortality</topic><topic>Osteosarcoma - pathology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Clara-Altamirano, M A</creatorcontrib><creatorcontrib>García-Ortega, D Y</creatorcontrib><creatorcontrib>Álvarez-Cano, A</creatorcontrib><creatorcontrib>Velázquez-Rodríguez, S</creatorcontrib><creatorcontrib>Lizcano-Suárez, A R</creatorcontrib><creatorcontrib>Rosas, L C</creatorcontrib><creatorcontrib>Uribe-Saloma, C E</creatorcontrib><creatorcontrib>Martínez-Said, H</creatorcontrib><creatorcontrib>Villavicencio-Valencia, V</creatorcontrib><creatorcontrib>Cuellar-Hubbe, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Acta ortopédica mexicana</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clara-Altamirano, M A</au><au>García-Ortega, D Y</au><au>Álvarez-Cano, A</au><au>Velázquez-Rodríguez, S</au><au>Lizcano-Suárez, A R</au><au>Rosas, L C</au><au>Uribe-Saloma, C E</au><au>Martínez-Said, H</au><au>Villavicencio-Valencia, V</au><au>Cuellar-Hubbe, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delayed diagnosis of osteosarcoma in adults: a prognostic factor to be considered</atitle><jtitle>Acta ortopédica mexicana</jtitle><addtitle>Acta Ortop Mex</addtitle><date>2024-05</date><risdate>2024</risdate><volume>38</volume><issue>3</issue><spage>164</spage><pages>164-</pages><issn>2306-4102</issn><abstract>different variables have been associated with a worse prognosis of patients with osteosarcoma (OS), highlighting tumor size, location in the axial skeleton and the presence of metastases. The objective of this study is to analyze the prognostic impact of diagnostic delay in osteosarcoma in adults in the Mexican population in a center specialized in sarcomas.
retrospective cohort study from January 1, 2005, to December 31, 2016, 96 patients over 21 years of age with a diagnosis of osteosarcoma were analyzed.
the median time to diagnosis from the onset of symptoms was six months (range: 2-36). This variable was dichotomized by applying the operator-dependent curve (ROC) analysis and we determined a cut-off value greater than five months, with an area under the curve (AUC) = 0.93 [95% CI 0.86-0.97], sensitivity 93.2% and specificity 94.6%.
time until diagnosis is a critical factor in the survival of adult patients with osteosarcoma, highlighting its influence on disease progression and the appearance of metastasis. The correlation between diagnostic delay and an unfavorable prognosis reinforces the need for rapid and efficient evaluation in suspected cases of osteosarcoma.</abstract><cop>Mexico</cop><pmid>38862146</pmid><doi>10.35366/115811</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2306-4102 |
| ispartof | Acta ortopédica mexicana, 2024-05, Vol.38 (3), p.164 |
| issn | 2306-4102 |
| language | spa |
| recordid | cdi_pubmed_primary_38862146 |
| source | MEDLINE; Medigraphic; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Bone Neoplasms - diagnosis Bone Neoplasms - pathology Cohort Studies Delayed Diagnosis Disease Progression Female Humans Male Mexico Middle Aged Osteosarcoma - diagnosis Osteosarcoma - mortality Osteosarcoma - pathology Prognosis Retrospective Studies ROC Curve Sensitivity and Specificity Time Factors Young Adult |
| title | Delayed diagnosis of osteosarcoma in adults: a prognostic factor to be considered |
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