Successful post-incomplete resection management of gastrointestinal stromal tumor using imatinib based on adenosine triphosphate-based tumor sensitivity assay in a dog
Gastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old spayed female M...
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| Veröffentlicht in: | Canadian veterinary journal 2024-06, Vol.65 (6), p.553-558 |
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| container_title | Canadian veterinary journal |
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| creator | Woo, In-Sun Kim, Young-Rok Kim, Sang-Won Choi, Jin-Young Yoon, Hun-Young Bae, Kieun Yoon, Kyong-Ah Kim, Jung-Hyun |
| description | Gastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old
spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses. An adenosine triphosphate-based tumor chemosensitivity assay revealed that imatinib at lower concentrations had a stronger inhibitory effect than toceranib.
Based on the results of the assay, the dog was treated with imatinib after surgery. After 28 mo of therapy, there was no recurrence of the tumor.Key clinical message:Adenosine triphosphate-based tumor chemosensitivity assays may help clinicians to select appropriate postoperative chemotherapeutic
drugs for incompletely resected gastrointestinal stromal tumors in dogs. |
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spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses. An adenosine triphosphate-based tumor chemosensitivity assay revealed that imatinib at lower concentrations had a stronger inhibitory effect than toceranib.
Based on the results of the assay, the dog was treated with imatinib after surgery. After 28 mo of therapy, there was no recurrence of the tumor.Key clinical message:Adenosine triphosphate-based tumor chemosensitivity assays may help clinicians to select appropriate postoperative chemotherapeutic
drugs for incompletely resected gastrointestinal stromal tumors in dogs.</description><identifier>ISSN: 0008-5286</identifier><identifier>PMID: 38827592</identifier><language>eng</language><publisher>Canada: Canadian Veterinary Medical Association</publisher><subject>Adenosine Triphosphate - therapeutic use ; Animals ; Antineoplastic Agents - therapeutic use ; Dog Diseases - drug therapy ; Dog Diseases - surgery ; Dogs ; Female ; Gastrointestinal Stromal Tumors - drug therapy ; Gastrointestinal Stromal Tumors - pathology ; Gastrointestinal Stromal Tumors - surgery ; Gastrointestinal Stromal Tumors - veterinary ; Imatinib Mesylate - therapeutic use ; Indoles ; Pyrroles ; Scientific</subject><ispartof>Canadian veterinary journal, 2024-06, Vol.65 (6), p.553-558</ispartof><rights>Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.</rights><rights>Copyright and/or publishing rights held by the Canadian Veterinary Medical Association 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132173/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132173/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38827592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woo, In-Sun</creatorcontrib><creatorcontrib>Kim, Young-Rok</creatorcontrib><creatorcontrib>Kim, Sang-Won</creatorcontrib><creatorcontrib>Choi, Jin-Young</creatorcontrib><creatorcontrib>Yoon, Hun-Young</creatorcontrib><creatorcontrib>Bae, Kieun</creatorcontrib><creatorcontrib>Yoon, Kyong-Ah</creatorcontrib><creatorcontrib>Kim, Jung-Hyun</creatorcontrib><title>Successful post-incomplete resection management of gastrointestinal stromal tumor using imatinib based on adenosine triphosphate-based tumor sensitivity assay in a dog</title><title>Canadian veterinary journal</title><addtitle>Can Vet J</addtitle><description>Gastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old
spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses. An adenosine triphosphate-based tumor chemosensitivity assay revealed that imatinib at lower concentrations had a stronger inhibitory effect than toceranib.
Based on the results of the assay, the dog was treated with imatinib after surgery. After 28 mo of therapy, there was no recurrence of the tumor.Key clinical message:Adenosine triphosphate-based tumor chemosensitivity assays may help clinicians to select appropriate postoperative chemotherapeutic
drugs for incompletely resected gastrointestinal stromal tumors in dogs.</description><subject>Adenosine Triphosphate - therapeutic use</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Dog Diseases - drug therapy</subject><subject>Dog Diseases - surgery</subject><subject>Dogs</subject><subject>Female</subject><subject>Gastrointestinal Stromal Tumors - drug therapy</subject><subject>Gastrointestinal Stromal Tumors - pathology</subject><subject>Gastrointestinal Stromal Tumors - surgery</subject><subject>Gastrointestinal Stromal Tumors - veterinary</subject><subject>Imatinib Mesylate - therapeutic use</subject><subject>Indoles</subject><subject>Pyrroles</subject><subject>Scientific</subject><issn>0008-5286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks2O1DAMx3sAscvCK6AcuVTKR5u2J0ArvqQVewDOkZu6nYzapMTpSMML8ZpkdgYEh83BdvS3f5adPCmuOedtWctWXxXPifacy05o_qy4Um0rm7qT18Wvr5u1SDRuM1sDpdJ5G5Z1xoQsIqFNLni2gIcJF_SJhZFNQCkG5xNSch5mdrou2adtCZFt5PzE3AJZdD3rgXBgGQID-pA1ZCm6dRdo3UHC8qyfSwk9ueQOLh0ZEMGRuVzHhjC9KJ6OMBO-vPib4vuH999uP5V39x8_3767K52SdSq7uuK2a7hA29ZSNMirVtnO6lFXWtZay16JXoIee4G86fpR2AFaqwSAakSnboo3Z-669QsONo8cYTZrzPPEowngzP-KdzszhYMRQqjcUGXC6wshhh9bXpFZHFmcZ_AYNjKK60qoTrQ6p776t9nfLn-eJye8PSfkjeZ-YPZhi3njZOxhgWz2RnJZGf5wdH0JuDYQ0yloMuLLIwhnz5TTLzl9EnPQtdcPQF4rbniVzYAjbHMyCaKZfhpq1G9957-q</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Woo, In-Sun</creator><creator>Kim, Young-Rok</creator><creator>Kim, Sang-Won</creator><creator>Choi, Jin-Young</creator><creator>Yoon, Hun-Young</creator><creator>Bae, Kieun</creator><creator>Yoon, Kyong-Ah</creator><creator>Kim, Jung-Hyun</creator><general>Canadian Veterinary Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240601</creationdate><title>Successful post-incomplete resection management of gastrointestinal stromal tumor using imatinib based on adenosine triphosphate-based tumor sensitivity assay in a dog</title><author>Woo, In-Sun ; Kim, Young-Rok ; Kim, Sang-Won ; Choi, Jin-Young ; Yoon, Hun-Young ; Bae, Kieun ; Yoon, Kyong-Ah ; Kim, Jung-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i325t-9540c9701ec85217e0483c9c6f64625662b31b2a6fb1e079bf1cda8c31aa37193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenosine Triphosphate - therapeutic use</topic><topic>Animals</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Dog Diseases - drug therapy</topic><topic>Dog Diseases - surgery</topic><topic>Dogs</topic><topic>Female</topic><topic>Gastrointestinal Stromal Tumors - drug therapy</topic><topic>Gastrointestinal Stromal Tumors - pathology</topic><topic>Gastrointestinal Stromal Tumors - surgery</topic><topic>Gastrointestinal Stromal Tumors - veterinary</topic><topic>Imatinib Mesylate - therapeutic use</topic><topic>Indoles</topic><topic>Pyrroles</topic><topic>Scientific</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woo, In-Sun</creatorcontrib><creatorcontrib>Kim, Young-Rok</creatorcontrib><creatorcontrib>Kim, Sang-Won</creatorcontrib><creatorcontrib>Choi, Jin-Young</creatorcontrib><creatorcontrib>Yoon, Hun-Young</creatorcontrib><creatorcontrib>Bae, Kieun</creatorcontrib><creatorcontrib>Yoon, Kyong-Ah</creatorcontrib><creatorcontrib>Kim, Jung-Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woo, In-Sun</au><au>Kim, Young-Rok</au><au>Kim, Sang-Won</au><au>Choi, Jin-Young</au><au>Yoon, Hun-Young</au><au>Bae, Kieun</au><au>Yoon, Kyong-Ah</au><au>Kim, Jung-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful post-incomplete resection management of gastrointestinal stromal tumor using imatinib based on adenosine triphosphate-based tumor sensitivity assay in a dog</atitle><jtitle>Canadian veterinary journal</jtitle><addtitle>Can Vet J</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>65</volume><issue>6</issue><spage>553</spage><epage>558</epage><pages>553-558</pages><issn>0008-5286</issn><abstract>Gastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old
spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses. An adenosine triphosphate-based tumor chemosensitivity assay revealed that imatinib at lower concentrations had a stronger inhibitory effect than toceranib.
Based on the results of the assay, the dog was treated with imatinib after surgery. After 28 mo of therapy, there was no recurrence of the tumor.Key clinical message:Adenosine triphosphate-based tumor chemosensitivity assays may help clinicians to select appropriate postoperative chemotherapeutic
drugs for incompletely resected gastrointestinal stromal tumors in dogs.</abstract><cop>Canada</cop><pub>Canadian Veterinary Medical Association</pub><pmid>38827592</pmid><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adenosine Triphosphate - therapeutic use Animals Antineoplastic Agents - therapeutic use Dog Diseases - drug therapy Dog Diseases - surgery Dogs Female Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - pathology Gastrointestinal Stromal Tumors - surgery Gastrointestinal Stromal Tumors - veterinary Imatinib Mesylate - therapeutic use Indoles Pyrroles Scientific |
| title | Successful post-incomplete resection management of gastrointestinal stromal tumor using imatinib based on adenosine triphosphate-based tumor sensitivity assay in a dog |
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