PBI-05204, a supercritical CO 2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death

Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and the underlying mechanisms. Treatment with PBI...

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Veröffentlicht in:	Neoplasia (New York, N.Y.) N.Y.), 2024-08, Vol.54, p.101008
Hauptverfasser:	Chakraborty, Sharmistha, Wei, Daoyan, Tran, Megan, Lang, Frederick F, Newman, Robert A, Yang, Peiying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Disease Models, Animal Endoplasmic Reticulum Chaperone BiP Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Mice Necroptosis - drug effects Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Plant Extracts - pharmacology Xenograft Model Antitumor Assays
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