Collagenase motors in gelatine-based hydrogels
Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such as the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes to enhance the collagenase-loa...
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| Veröffentlicht in: | Nanoscale 2024-05, Vol.16 (2), p.9935-9943 |
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| creator | Wang, Nanying Floriano Marcelino, Thaís Ade, Carina Pendlmayr, Stefan Ramos Docampo, Miguel A Städler, Brigitte |
| description | Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such as the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes to enhance the collagenase-loading capacity of silica particle-based motors with the aim to systematically investigate the impact of gelatine viscosity, motors' size, and morphology on their propulsion velocity. Notably, 500 nm and 1 μm motors achieve similar speeds as high as ∼15 μm s
−1
in stiff gelatine-based hydrogels when triggered with calcium. Taken together, our findings highlight the potential of collagenase-based motors for navigating the extracellular matrix, positioning them as promising candidates for efficient drug delivery.
Motors equipped with collagenase trapped in polymer brushes exhibit high speeds of up to ∼15 μm s
−1
in stiff gelatine hydrogels when activated with calcium, showing potential as effective carriers for drug delivery across the extracellular matrix. |
| doi_str_mv | 10.1039/d3nr05712g |
| format | Article |
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−1
in stiff gelatine-based hydrogels when triggered with calcium. Taken together, our findings highlight the potential of collagenase-based motors for navigating the extracellular matrix, positioning them as promising candidates for efficient drug delivery.
Motors equipped with collagenase trapped in polymer brushes exhibit high speeds of up to ∼15 μm s
−1
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−1
in stiff gelatine-based hydrogels when triggered with calcium. Taken together, our findings highlight the potential of collagenase-based motors for navigating the extracellular matrix, positioning them as promising candidates for efficient drug delivery.
Motors equipped with collagenase trapped in polymer brushes exhibit high speeds of up to ∼15 μm s
−1
in stiff gelatine hydrogels when activated with calcium, showing potential as effective carriers for drug delivery across the extracellular matrix.</description><subject>Calcium - chemistry</subject><subject>Calcium - metabolism</subject><subject>Collagenases - chemistry</subject><subject>Collagenases - metabolism</subject><subject>Gelatin - chemistry</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Micromotors</subject><subject>Motors</subject><subject>Silicon Dioxide - chemistry</subject><subject>Viscosity</subject><issn>2040-3364</issn><issn>2040-3372</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFLw0AQhRdRbK1evCsBLyKk7u4ks9mjRK1CURA9h02yqSlJtu4mh_57t7ZW8DTDvI_H4w0h54xOGQV5W0JnaSwYXxyQMacRDQEEP9zvGI3IiXNLSlECwjEZQYKSJpSPyTQ1TaMWulNOB63pjXVB3QUL3ai-7nSY-3sZfK5La_zNnZKjSjVOn-3mhHw8PrynT-H8dfac3s3DgkvsQyElh4gWEEeIyASXFcUSuSpjhYCV8hLkCRZRnkOSVIAxE1Ve-ryejRAm5Hrru7Lma9Cuz9raFdpH7bQZXAY0pkwILphHr_6hSzPYzqfbUEns_WPpqZstVVjjnNVVtrJ1q-w6YzTbtJjdw8vbT4szD1_uLIe81eUe_a3NAxdbwLpir_69Ab4BJPZzbA</recordid><startdate>20240523</startdate><enddate>20240523</enddate><creator>Wang, Nanying</creator><creator>Floriano Marcelino, Thaís</creator><creator>Ade, Carina</creator><creator>Pendlmayr, Stefan</creator><creator>Ramos Docampo, Miguel A</creator><creator>Städler, Brigitte</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7335-3945</orcidid><orcidid>https://orcid.org/0000-0002-2714-0164</orcidid></search><sort><creationdate>20240523</creationdate><title>Collagenase motors in gelatine-based hydrogels</title><author>Wang, Nanying ; Floriano Marcelino, Thaís ; Ade, Carina ; Pendlmayr, Stefan ; Ramos Docampo, Miguel A ; Städler, Brigitte</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-7992340c3546661729f06d62ad5a636fa0c33b86c4bb388f36517fbd040729463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Calcium - chemistry</topic><topic>Calcium - metabolism</topic><topic>Collagenases - chemistry</topic><topic>Collagenases - metabolism</topic><topic>Gelatin - chemistry</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Micromotors</topic><topic>Motors</topic><topic>Silicon Dioxide - chemistry</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Nanying</creatorcontrib><creatorcontrib>Floriano Marcelino, Thaís</creatorcontrib><creatorcontrib>Ade, Carina</creatorcontrib><creatorcontrib>Pendlmayr, Stefan</creatorcontrib><creatorcontrib>Ramos Docampo, Miguel A</creatorcontrib><creatorcontrib>Städler, Brigitte</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Nanying</au><au>Floriano Marcelino, Thaís</au><au>Ade, Carina</au><au>Pendlmayr, Stefan</au><au>Ramos Docampo, Miguel A</au><au>Städler, Brigitte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagenase motors in gelatine-based hydrogels</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2024-05-23</date><risdate>2024</risdate><volume>16</volume><issue>2</issue><spage>9935</spage><epage>9943</epage><pages>9935-9943</pages><issn>2040-3364</issn><issn>2040-3372</issn><eissn>2040-3372</eissn><abstract>Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such as the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes to enhance the collagenase-loading capacity of silica particle-based motors with the aim to systematically investigate the impact of gelatine viscosity, motors' size, and morphology on their propulsion velocity. Notably, 500 nm and 1 μm motors achieve similar speeds as high as ∼15 μm s
−1
in stiff gelatine-based hydrogels when triggered with calcium. Taken together, our findings highlight the potential of collagenase-based motors for navigating the extracellular matrix, positioning them as promising candidates for efficient drug delivery.
Motors equipped with collagenase trapped in polymer brushes exhibit high speeds of up to ∼15 μm s
−1
in stiff gelatine hydrogels when activated with calcium, showing potential as effective carriers for drug delivery across the extracellular matrix.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38690802</pmid><doi>10.1039/d3nr05712g</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7335-3945</orcidid><orcidid>https://orcid.org/0000-0002-2714-0164</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2040-3364 |
| ispartof | Nanoscale, 2024-05, Vol.16 (2), p.9935-9943 |
| issn | 2040-3364 2040-3372 2040-3372 |
| language | eng |
| recordid | cdi_pubmed_primary_38690802 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Calcium - chemistry Calcium - metabolism Collagenases - chemistry Collagenases - metabolism Gelatin - chemistry Hydrogels Hydrogels - chemistry Micromotors Motors Silicon Dioxide - chemistry Viscosity |
| title | Collagenase motors in gelatine-based hydrogels |
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