Development of actin dimerization inducers inspired by actin-depolymerizing macrolides

Several natural cytotoxic C 2 -symmetric bis-lactones, such as swinholide A and rhizopodin, sequester actin dimer from the actin network and potently inhibit actin dynamics. To develop new protein-protein interaction (PPI) modulators, we synthesized structurally simplified actin-binding side-chain d...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2024-05, Vol.6 (37), p.491-4913
Hauptverfasser:	Itakura, Moeka, Utomo, Didik Huswo, Kita, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Depolymerizing Factors - chemistry Actin Depolymerizing Factors - pharmacology Actins - chemistry Actins - metabolism Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Chains Depolymerization Dimerization Dimers Lactones Macrolides - chemical synthesis Macrolides - chemistry Macrolides - pharmacology Modulators Molecular dynamics Molecular Dynamics Simulation Protein Multimerization - drug effects Proteins
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