Irradiation and Prolactin Effects on Rat Mammary Carcinogenesis: Intrasplenic Pituitary and Estrone Capsule Implants

The implantation of silicone capsules that contained estrone and that were adjacent to grafts of anterior pituitary tissue in the spleens of adrenalectomized glucocorticoid-deficient inbred F344 rats resulted in high circulating prolactin (Prl) levels without the untoward effects of chronic hyperest...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1985-07, Vol.75 (1), p.167-175
Hauptverfasser:	Clifton, Kelly H., Yasukawa-Barnes, Jane, Tanner, Martin A., Haning, Ray V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenofibroma - chemically induced Adenofibroma - etiology Adrenalectomy Animal tumors. Experimental tumors Animals Biological and medical sciences Carcinoma - chemically induced Carcinoma - etiology Castration Disease Susceptibility Drug Implants Estrone - administration & dosage Estrone - blood Estrone - toxicity Experimental genital and mammary tumors Female Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - etiology Medical sciences Neoplasms, Radiation-Induced - etiology Pituitary Gland, Anterior - secretion Pituitary Gland, Anterior - transplantation Prolactin - blood Prolactin - secretion Rats Rats, Inbred F344 Spleen Time Factors Tumors
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