Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation
Osteoarthritis is the most prevalent degenerative joint disease reported worldwide. Conventional treatment strategies mainly focus on medication and involve surgical joint replacement. The use of these therapies is limited by gastrointestinal complications and the lifespan of joint prostheses. Hence...
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| creator | Xue, Hong Zhou, Hongyu Lou, Qiliang Yuan, Putao Feng, Zhenhua Qiao, Li Zhang, Jiateng Xie, Hongwei Shen, Yang Ma, Qingliang Wang, Shiyu Zhang, Boya Ye, Huali Cheng, Jiao Sun, Xuewu Shi, Peihua |
| description | Osteoarthritis is the most prevalent degenerative joint disease reported worldwide. Conventional treatment strategies mainly focus on medication and involve surgical joint replacement. The use of these therapies is limited by gastrointestinal complications and the lifespan of joint prostheses. Hence, safe and efficacious drugs are urgently needed to impede the osteoarthritis progression. Urolithin B, a metabolite of ellagic acid in the gut, exhibits anti-inflammatory and antioxidant properties; however, its role in osteoarthritis remains unclear. In this study, we demonstrated that urolithin B efficiently inhibits the inflammatory factor-induced production of matrix metalloproteinases (MMP3 and MMP13)
in vitro
and upregulates the expression of type II collagen and aggrecan. Urolithin B alleviates cartilage erosion and osteophyte formation induced by anterior cruciate ligament transections. Moreover, urolithin B inhibits the activation of the NF-κB pathway by reducing the phosphorylation of Iκb-α and the nuclear translocation of P65. In summary, urolithin B significantly inhibits inflammation and alleviates osteoarthritis. Hence, urolithin B can be considered a potential agent suitable for the effective treatment of osteoarthritis in the future.
Urolithin B, generated through the metabolism of microbiota, exhibits anti-inflammatory and cartilage-protective effects. |
| doi_str_mv | 10.1039/d3fo03793b |
| format | Article |
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in vitro
and upregulates the expression of type II collagen and aggrecan. Urolithin B alleviates cartilage erosion and osteophyte formation induced by anterior cruciate ligament transections. Moreover, urolithin B inhibits the activation of the NF-κB pathway by reducing the phosphorylation of Iκb-α and the nuclear translocation of P65. In summary, urolithin B significantly inhibits inflammation and alleviates osteoarthritis. Hence, urolithin B can be considered a potential agent suitable for the effective treatment of osteoarthritis in the future.
Urolithin B, generated through the metabolism of microbiota, exhibits anti-inflammatory and cartilage-protective effects.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d3fo03793b</identifier><identifier>PMID: 38465899</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aggrecan ; Anterior cruciate ligament ; Arthritis ; Cartilage ; Cartilage - metabolism ; Cartilage diseases ; Chondrocytes ; Collagen (type II) ; Collagenase 3 ; Coumarins ; Degeneration ; Ellagic acid ; Humans ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Interleukin-1beta - metabolism ; Joint diseases ; Joints (anatomy) ; Life span ; Matrix metalloproteinase ; Matrix metalloproteinases ; Metabolites ; NF-kappa B - genetics ; NF-kappa B - metabolism ; NF-κB protein ; Nuclear transport ; Osteoarthritis ; Osteoarthritis - drug therapy ; Osteoarthritis - metabolism ; Phosphorylation ; Prostheses ; Prosthetics ; Signal Transduction ; Stromelysin 1 ; Translocation</subject><ispartof>Food & function, 2024-04, Vol.15 (7), p.3552-3565</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c332t-171354fa10c9c7c6b34a2f28b61ee6a3acaf22f29594e78eeec2fb2859bfbf73</cites><orcidid>0000-0002-2063-0419 ; 0000-0002-5127-5456</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38465899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Hong</creatorcontrib><creatorcontrib>Zhou, Hongyu</creatorcontrib><creatorcontrib>Lou, Qiliang</creatorcontrib><creatorcontrib>Yuan, Putao</creatorcontrib><creatorcontrib>Feng, Zhenhua</creatorcontrib><creatorcontrib>Qiao, Li</creatorcontrib><creatorcontrib>Zhang, Jiateng</creatorcontrib><creatorcontrib>Xie, Hongwei</creatorcontrib><creatorcontrib>Shen, Yang</creatorcontrib><creatorcontrib>Ma, Qingliang</creatorcontrib><creatorcontrib>Wang, Shiyu</creatorcontrib><creatorcontrib>Zhang, Boya</creatorcontrib><creatorcontrib>Ye, Huali</creatorcontrib><creatorcontrib>Cheng, Jiao</creatorcontrib><creatorcontrib>Sun, Xuewu</creatorcontrib><creatorcontrib>Shi, Peihua</creatorcontrib><title>Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Osteoarthritis is the most prevalent degenerative joint disease reported worldwide. Conventional treatment strategies mainly focus on medication and involve surgical joint replacement. The use of these therapies is limited by gastrointestinal complications and the lifespan of joint prostheses. Hence, safe and efficacious drugs are urgently needed to impede the osteoarthritis progression. Urolithin B, a metabolite of ellagic acid in the gut, exhibits anti-inflammatory and antioxidant properties; however, its role in osteoarthritis remains unclear. In this study, we demonstrated that urolithin B efficiently inhibits the inflammatory factor-induced production of matrix metalloproteinases (MMP3 and MMP13)
in vitro
and upregulates the expression of type II collagen and aggrecan. Urolithin B alleviates cartilage erosion and osteophyte formation induced by anterior cruciate ligament transections. Moreover, urolithin B inhibits the activation of the NF-κB pathway by reducing the phosphorylation of Iκb-α and the nuclear translocation of P65. In summary, urolithin B significantly inhibits inflammation and alleviates osteoarthritis. Hence, urolithin B can be considered a potential agent suitable for the effective treatment of osteoarthritis in the future.
Urolithin B, generated through the metabolism of microbiota, exhibits anti-inflammatory and cartilage-protective effects.</description><subject>Aggrecan</subject><subject>Anterior cruciate ligament</subject><subject>Arthritis</subject><subject>Cartilage</subject><subject>Cartilage - metabolism</subject><subject>Cartilage diseases</subject><subject>Chondrocytes</subject><subject>Collagen (type II)</subject><subject>Collagenase 3</subject><subject>Coumarins</subject><subject>Degeneration</subject><subject>Ellagic acid</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Interleukin-1beta - metabolism</subject><subject>Joint diseases</subject><subject>Joints (anatomy)</subject><subject>Life span</subject><subject>Matrix metalloproteinase</subject><subject>Matrix metalloproteinases</subject><subject>Metabolites</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Nuclear transport</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - drug therapy</subject><subject>Osteoarthritis - metabolism</subject><subject>Phosphorylation</subject><subject>Prostheses</subject><subject>Prosthetics</subject><subject>Signal Transduction</subject><subject>Stromelysin 1</subject><subject>Translocation</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1LAzEQhoMottRevCsLXkSoZpP9ytFWq0KhlwreliQ7aVN2k5rsCv33xrZWcC7z9cwwvIPQZYzvY0zZQ0WVxTRnVJygPsEJGWUp_jj9jROW9dDQ-zUORhkrWHGOerRIsrRgrI_ku7O1blfaROPIQdVJ8JHkrtU1X0JUwRIMON5qayJuqojXNXxp3gbK-hZsIFdOt9pHYhtps9IiJGYZQlXzptkNXqAzxWsPw4MfoMX0eTF5Hc3mL2-Tx9lIUkraUZzHNE0Uj7FkMpeZoAknihQiiwEyTrnkioQCS1kCeQEAkihBipQJJVROB-h2v3bj7GcHvi0b7SXUNTdgO1-GwZRkabCA3vxD17ZzJhxXUkxxViRBp0Dd7SnprPcOVLlxuuFuW8a4_BG_fKLT-U78cYCvDys70UB1RH-lDsDVHnBeHrt_36PfW72K4w</recordid><startdate>20240402</startdate><enddate>20240402</enddate><creator>Xue, Hong</creator><creator>Zhou, Hongyu</creator><creator>Lou, Qiliang</creator><creator>Yuan, Putao</creator><creator>Feng, Zhenhua</creator><creator>Qiao, Li</creator><creator>Zhang, Jiateng</creator><creator>Xie, Hongwei</creator><creator>Shen, Yang</creator><creator>Ma, Qingliang</creator><creator>Wang, Shiyu</creator><creator>Zhang, Boya</creator><creator>Ye, Huali</creator><creator>Cheng, Jiao</creator><creator>Sun, Xuewu</creator><creator>Shi, Peihua</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2063-0419</orcidid><orcidid>https://orcid.org/0000-0002-5127-5456</orcidid></search><sort><creationdate>20240402</creationdate><title>Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation</title><author>Xue, Hong ; Zhou, Hongyu ; Lou, Qiliang ; Yuan, Putao ; Feng, Zhenhua ; Qiao, Li ; Zhang, Jiateng ; Xie, Hongwei ; Shen, Yang ; Ma, Qingliang ; Wang, Shiyu ; Zhang, Boya ; Ye, Huali ; Cheng, Jiao ; Sun, Xuewu ; Shi, Peihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-171354fa10c9c7c6b34a2f28b61ee6a3acaf22f29594e78eeec2fb2859bfbf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aggrecan</topic><topic>Anterior cruciate ligament</topic><topic>Arthritis</topic><topic>Cartilage</topic><topic>Cartilage - metabolism</topic><topic>Cartilage diseases</topic><topic>Chondrocytes</topic><topic>Collagen (type II)</topic><topic>Collagenase 3</topic><topic>Coumarins</topic><topic>Degeneration</topic><topic>Ellagic acid</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Interleukin-1beta - metabolism</topic><topic>Joint diseases</topic><topic>Joints (anatomy)</topic><topic>Life span</topic><topic>Matrix metalloproteinase</topic><topic>Matrix metalloproteinases</topic><topic>Metabolites</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Nuclear transport</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - drug therapy</topic><topic>Osteoarthritis - metabolism</topic><topic>Phosphorylation</topic><topic>Prostheses</topic><topic>Prosthetics</topic><topic>Signal Transduction</topic><topic>Stromelysin 1</topic><topic>Translocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Hong</creatorcontrib><creatorcontrib>Zhou, Hongyu</creatorcontrib><creatorcontrib>Lou, Qiliang</creatorcontrib><creatorcontrib>Yuan, Putao</creatorcontrib><creatorcontrib>Feng, Zhenhua</creatorcontrib><creatorcontrib>Qiao, Li</creatorcontrib><creatorcontrib>Zhang, Jiateng</creatorcontrib><creatorcontrib>Xie, Hongwei</creatorcontrib><creatorcontrib>Shen, Yang</creatorcontrib><creatorcontrib>Ma, Qingliang</creatorcontrib><creatorcontrib>Wang, Shiyu</creatorcontrib><creatorcontrib>Zhang, Boya</creatorcontrib><creatorcontrib>Ye, Huali</creatorcontrib><creatorcontrib>Cheng, Jiao</creatorcontrib><creatorcontrib>Sun, Xuewu</creatorcontrib><creatorcontrib>Shi, Peihua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Hong</au><au>Zhou, Hongyu</au><au>Lou, Qiliang</au><au>Yuan, Putao</au><au>Feng, Zhenhua</au><au>Qiao, Li</au><au>Zhang, Jiateng</au><au>Xie, Hongwei</au><au>Shen, Yang</au><au>Ma, Qingliang</au><au>Wang, Shiyu</au><au>Zhang, Boya</au><au>Ye, Huali</au><au>Cheng, Jiao</au><au>Sun, Xuewu</au><au>Shi, Peihua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2024-04-02</date><risdate>2024</risdate><volume>15</volume><issue>7</issue><spage>3552</spage><epage>3565</epage><pages>3552-3565</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Osteoarthritis is the most prevalent degenerative joint disease reported worldwide. Conventional treatment strategies mainly focus on medication and involve surgical joint replacement. The use of these therapies is limited by gastrointestinal complications and the lifespan of joint prostheses. Hence, safe and efficacious drugs are urgently needed to impede the osteoarthritis progression. Urolithin B, a metabolite of ellagic acid in the gut, exhibits anti-inflammatory and antioxidant properties; however, its role in osteoarthritis remains unclear. In this study, we demonstrated that urolithin B efficiently inhibits the inflammatory factor-induced production of matrix metalloproteinases (MMP3 and MMP13)
in vitro
and upregulates the expression of type II collagen and aggrecan. Urolithin B alleviates cartilage erosion and osteophyte formation induced by anterior cruciate ligament transections. Moreover, urolithin B inhibits the activation of the NF-κB pathway by reducing the phosphorylation of Iκb-α and the nuclear translocation of P65. In summary, urolithin B significantly inhibits inflammation and alleviates osteoarthritis. Hence, urolithin B can be considered a potential agent suitable for the effective treatment of osteoarthritis in the future.
Urolithin B, generated through the metabolism of microbiota, exhibits anti-inflammatory and cartilage-protective effects.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38465899</pmid><doi>10.1039/d3fo03793b</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-2063-0419</orcidid><orcidid>https://orcid.org/0000-0002-5127-5456</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aggrecan Anterior cruciate ligament Arthritis Cartilage Cartilage - metabolism Cartilage diseases Chondrocytes Collagen (type II) Collagenase 3 Coumarins Degeneration Ellagic acid Humans Inflammation Inflammation - drug therapy Inflammation - metabolism Interleukin-1beta - metabolism Joint diseases Joints (anatomy) Life span Matrix metalloproteinase Matrix metalloproteinases Metabolites NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Nuclear transport Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism Phosphorylation Prostheses Prosthetics Signal Transduction Stromelysin 1 Translocation |
| title | Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation |
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