Diagnostic value of 18 F - PSMA - 1007 PET/CT combined with prostate specific antigen derived indicators in gray area prostate cancer
The incidence of prostate cancer is increasing every year, and precision diagnosis and treatment can help reduce unnecessary prostate punctures for prostate cancer patients in the gray area. This study aims to investigate the diagnostic value of F-prostate specific membrane antigen (PSMA) imaging co...
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| Veröffentlicht in: | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2023-12, Vol.48 (12), p.1812 |
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| container_title | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban |
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| creator | Guo, Sheng Zhou, Chuan Zhang, Yunfeng Wang, Dong Niu, Tao Zhou, Fenghai |
| description | The incidence of prostate cancer is increasing every year, and precision diagnosis and treatment can help reduce unnecessary prostate punctures for prostate cancer patients in the gray area. This study aims to investigate the diagnostic value of
F-prostate specific membrane antigen (PSMA) imaging combined with prostate specific antigen (PSA)-derived indicators for gray zone prostate cancer.
A total of 107 patients who underwent
F-PSMA PET/CT imaging for suspicious prostate cancer with tPSA of 4 to 10 μg/L (PSA gray zone) in a hospital were retrospectively included, and were divided into a prostate cancer group and a non-prostate cancer group based on pathological findings. Patients underwent PSA testing,
F-PSMA, and abdominal ultrasound, and age, tPSA, fPSA, f/tPSA, prostate volume, PSA density (PSAD), maximum standardized uptake value (SUVmax), and molecular imaging prostate specific membrane antigen (miPSMA) score were compared between the 2 groups. Multivariate logistic regression was used to analyze the influencing factors the diagnosis of gray zone prostate cancer. Receiver operating characteristic (ROC) curves were constructed to evaluate the efficacy of PSAD and SUVmax alone and in combination in diagnosing gray zone prostate cancer.
The volume of the prostate cancer group [42.00(34.00, 58.00) cm
vs 49.00(41.27, 60.41) cm
] was smaller than that of the non-prostate cancer group (
=-2.376,
=0.017), and the PSAD [(0.18±0.06) μg/(L·cm
) vs 0.15±0.05 μg/(L·cm
)] and SUVmax [18.63(8.03, 28.57) vs 9.33(5.90, 13.52)] were higher than those in the non-prostate cancer group (both |
| doi_str_mv | 10.11817/j.issn.1672-7347.2023.230268 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_38448374</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>38448374</sourcerecordid><originalsourceid>FETCH-pubmed_primary_384483743</originalsourceid><addsrcrecordid>eNqFTs1OwzAYywHEJtgroO_CsVl-ypIrGpu4IE2i9-lbmpZvWtMqyYb2ALw3RQJ2xBdblm2ZsQcpuJRWmvmeU0qBy4VRhdGl4UoozZUWamGv2PTPn7BZSnshhHqU37hhE23L0mpTTtnnM2Eb-pTJwQkPRw99A9LCGgrYvL0-jSSFMLBZVfNlBa7vdhR8DR-U32GIYxGzhzR4R804gSFT6wPUPtJpjFGoyWHuYxoltBHPgNHjpekwOB_v2HWDh-RnP3zL7teravlSDMdd5-vtEKnDeN7-_tb_Br4AFTxV7w</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Diagnostic value of 18 F - PSMA - 1007 PET/CT combined with prostate specific antigen derived indicators in gray area prostate cancer</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Guo, Sheng ; Zhou, Chuan ; Zhang, Yunfeng ; Wang, Dong ; Niu, Tao ; Zhou, Fenghai</creator><creatorcontrib>Guo, Sheng ; Zhou, Chuan ; Zhang, Yunfeng ; Wang, Dong ; Niu, Tao ; Zhou, Fenghai</creatorcontrib><description>The incidence of prostate cancer is increasing every year, and precision diagnosis and treatment can help reduce unnecessary prostate punctures for prostate cancer patients in the gray area. This study aims to investigate the diagnostic value of
F-prostate specific membrane antigen (PSMA) imaging combined with prostate specific antigen (PSA)-derived indicators for gray zone prostate cancer.
A total of 107 patients who underwent
F-PSMA PET/CT imaging for suspicious prostate cancer with tPSA of 4 to 10 μg/L (PSA gray zone) in a hospital were retrospectively included, and were divided into a prostate cancer group and a non-prostate cancer group based on pathological findings. Patients underwent PSA testing,
F-PSMA, and abdominal ultrasound, and age, tPSA, fPSA, f/tPSA, prostate volume, PSA density (PSAD), maximum standardized uptake value (SUVmax), and molecular imaging prostate specific membrane antigen (miPSMA) score were compared between the 2 groups. Multivariate logistic regression was used to analyze the influencing factors the diagnosis of gray zone prostate cancer. Receiver operating characteristic (ROC) curves were constructed to evaluate the efficacy of PSAD and SUVmax alone and in combination in diagnosing gray zone prostate cancer.
The volume of the prostate cancer group [42.00(34.00, 58.00) cm
vs 49.00(41.27, 60.41) cm
] was smaller than that of the non-prostate cancer group (
=-2.376,
=0.017), and the PSAD [(0.18±0.06) μg/(L·cm
) vs 0.15±0.05 μg/(L·cm
)] and SUVmax [18.63(8.03, 28.57) vs 9.33(5.90, 13.52)] were higher than those in the non-prostate cancer group (both
<0.05). The percentage of miPSMA score ≥2 in the prostate cancer group was higher than that in the non-prostate cancer group (
=40.987,
0.001). PSAD (
=22.154, 95%
1.430 to 873.751,
=0.042) and SUVmax (
=1.301, 95%
1.034 to 1.678,
=0.009) were independent influential factors for the diagnosis of prostate cancer in the gray zone. The optimal cut-off values of PSAD and SUVmax were 0.22 μg/(L·cm
) and 8.02, respectively, and the AUCs for the diagnosis of prostate cancer in the gray zone alone and in combination were 0.628 (95%
0.530 to 0.720,
<0.05) and 0.806 (95%
0.718 to 0.876,
<0.05), 0.847 (95%
0.765 to 0.910,
<0.05), with sensitivities of 41.03%, 76.92%, and 74.36% and specificities of 79.41%, 89.71%, and 92.65%, respectively.
PSAD and SUVmax are increased in patients with gray zone prostate cancer, and the combination of PSAD and SUVmax is of high value in diagnosing gray zone prostate cancer.</description><identifier>ISSN: 1672-7347</identifier><identifier>DOI: 10.11817/j.issn.1672-7347.2023.230268</identifier><identifier>PMID: 38448374</identifier><language>eng</language><publisher>China</publisher><subject>Humans ; Male ; Niacinamide - analogs & derivatives ; Oligopeptides ; Positron Emission Tomography Computed Tomography ; Prostate-Specific Antigen ; Prostatic Neoplasms - diagnostic imaging ; Retrospective Studies</subject><ispartof>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2023-12, Vol.48 (12), p.1812</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38448374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Sheng</creatorcontrib><creatorcontrib>Zhou, Chuan</creatorcontrib><creatorcontrib>Zhang, Yunfeng</creatorcontrib><creatorcontrib>Wang, Dong</creatorcontrib><creatorcontrib>Niu, Tao</creatorcontrib><creatorcontrib>Zhou, Fenghai</creatorcontrib><title>Diagnostic value of 18 F - PSMA - 1007 PET/CT combined with prostate specific antigen derived indicators in gray area prostate cancer</title><title>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</title><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><description>The incidence of prostate cancer is increasing every year, and precision diagnosis and treatment can help reduce unnecessary prostate punctures for prostate cancer patients in the gray area. This study aims to investigate the diagnostic value of
F-prostate specific membrane antigen (PSMA) imaging combined with prostate specific antigen (PSA)-derived indicators for gray zone prostate cancer.
A total of 107 patients who underwent
F-PSMA PET/CT imaging for suspicious prostate cancer with tPSA of 4 to 10 μg/L (PSA gray zone) in a hospital were retrospectively included, and were divided into a prostate cancer group and a non-prostate cancer group based on pathological findings. Patients underwent PSA testing,
F-PSMA, and abdominal ultrasound, and age, tPSA, fPSA, f/tPSA, prostate volume, PSA density (PSAD), maximum standardized uptake value (SUVmax), and molecular imaging prostate specific membrane antigen (miPSMA) score were compared between the 2 groups. Multivariate logistic regression was used to analyze the influencing factors the diagnosis of gray zone prostate cancer. Receiver operating characteristic (ROC) curves were constructed to evaluate the efficacy of PSAD and SUVmax alone and in combination in diagnosing gray zone prostate cancer.
The volume of the prostate cancer group [42.00(34.00, 58.00) cm
vs 49.00(41.27, 60.41) cm
] was smaller than that of the non-prostate cancer group (
=-2.376,
=0.017), and the PSAD [(0.18±0.06) μg/(L·cm
) vs 0.15±0.05 μg/(L·cm
)] and SUVmax [18.63(8.03, 28.57) vs 9.33(5.90, 13.52)] were higher than those in the non-prostate cancer group (both
<0.05). The percentage of miPSMA score ≥2 in the prostate cancer group was higher than that in the non-prostate cancer group (
=40.987,
0.001). PSAD (
=22.154, 95%
1.430 to 873.751,
=0.042) and SUVmax (
=1.301, 95%
1.034 to 1.678,
=0.009) were independent influential factors for the diagnosis of prostate cancer in the gray zone. The optimal cut-off values of PSAD and SUVmax were 0.22 μg/(L·cm
) and 8.02, respectively, and the AUCs for the diagnosis of prostate cancer in the gray zone alone and in combination were 0.628 (95%
0.530 to 0.720,
<0.05) and 0.806 (95%
0.718 to 0.876,
<0.05), 0.847 (95%
0.765 to 0.910,
<0.05), with sensitivities of 41.03%, 76.92%, and 74.36% and specificities of 79.41%, 89.71%, and 92.65%, respectively.
PSAD and SUVmax are increased in patients with gray zone prostate cancer, and the combination of PSAD and SUVmax is of high value in diagnosing gray zone prostate cancer.</description><subject>Humans</subject><subject>Male</subject><subject>Niacinamide - analogs & derivatives</subject><subject>Oligopeptides</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Prostate-Specific Antigen</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Retrospective Studies</subject><issn>1672-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFTs1OwzAYywHEJtgroO_CsVl-ypIrGpu4IE2i9-lbmpZvWtMqyYb2ALw3RQJ2xBdblm2ZsQcpuJRWmvmeU0qBy4VRhdGl4UoozZUWamGv2PTPn7BZSnshhHqU37hhE23L0mpTTtnnM2Eb-pTJwQkPRw99A9LCGgrYvL0-jSSFMLBZVfNlBa7vdhR8DR-U32GIYxGzhzR4R804gSFT6wPUPtJpjFGoyWHuYxoltBHPgNHjpekwOB_v2HWDh-RnP3zL7teravlSDMdd5-vtEKnDeN7-_tb_Br4AFTxV7w</recordid><startdate>20231228</startdate><enddate>20231228</enddate><creator>Guo, Sheng</creator><creator>Zhou, Chuan</creator><creator>Zhang, Yunfeng</creator><creator>Wang, Dong</creator><creator>Niu, Tao</creator><creator>Zhou, Fenghai</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20231228</creationdate><title>Diagnostic value of 18 F - PSMA - 1007 PET/CT combined with prostate specific antigen derived indicators in gray area prostate cancer</title><author>Guo, Sheng ; Zhou, Chuan ; Zhang, Yunfeng ; Wang, Dong ; Niu, Tao ; Zhou, Fenghai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_384483743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Humans</topic><topic>Male</topic><topic>Niacinamide - analogs & derivatives</topic><topic>Oligopeptides</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Prostate-Specific Antigen</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Retrospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Guo, Sheng</creatorcontrib><creatorcontrib>Zhou, Chuan</creatorcontrib><creatorcontrib>Zhang, Yunfeng</creatorcontrib><creatorcontrib>Wang, Dong</creatorcontrib><creatorcontrib>Niu, Tao</creatorcontrib><creatorcontrib>Zhou, Fenghai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Sheng</au><au>Zhou, Chuan</au><au>Zhang, Yunfeng</au><au>Wang, Dong</au><au>Niu, Tao</au><au>Zhou, Fenghai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of 18 F - PSMA - 1007 PET/CT combined with prostate specific antigen derived indicators in gray area prostate cancer</atitle><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><date>2023-12-28</date><risdate>2023</risdate><volume>48</volume><issue>12</issue><spage>1812</spage><pages>1812-</pages><issn>1672-7347</issn><abstract>The incidence of prostate cancer is increasing every year, and precision diagnosis and treatment can help reduce unnecessary prostate punctures for prostate cancer patients in the gray area. This study aims to investigate the diagnostic value of
F-prostate specific membrane antigen (PSMA) imaging combined with prostate specific antigen (PSA)-derived indicators for gray zone prostate cancer.
A total of 107 patients who underwent
F-PSMA PET/CT imaging for suspicious prostate cancer with tPSA of 4 to 10 μg/L (PSA gray zone) in a hospital were retrospectively included, and were divided into a prostate cancer group and a non-prostate cancer group based on pathological findings. Patients underwent PSA testing,
F-PSMA, and abdominal ultrasound, and age, tPSA, fPSA, f/tPSA, prostate volume, PSA density (PSAD), maximum standardized uptake value (SUVmax), and molecular imaging prostate specific membrane antigen (miPSMA) score were compared between the 2 groups. Multivariate logistic regression was used to analyze the influencing factors the diagnosis of gray zone prostate cancer. Receiver operating characteristic (ROC) curves were constructed to evaluate the efficacy of PSAD and SUVmax alone and in combination in diagnosing gray zone prostate cancer.
The volume of the prostate cancer group [42.00(34.00, 58.00) cm
vs 49.00(41.27, 60.41) cm
] was smaller than that of the non-prostate cancer group (
=-2.376,
=0.017), and the PSAD [(0.18±0.06) μg/(L·cm
) vs 0.15±0.05 μg/(L·cm
)] and SUVmax [18.63(8.03, 28.57) vs 9.33(5.90, 13.52)] were higher than those in the non-prostate cancer group (both
<0.05). The percentage of miPSMA score ≥2 in the prostate cancer group was higher than that in the non-prostate cancer group (
=40.987,
0.001). PSAD (
=22.154, 95%
1.430 to 873.751,
=0.042) and SUVmax (
=1.301, 95%
1.034 to 1.678,
=0.009) were independent influential factors for the diagnosis of prostate cancer in the gray zone. The optimal cut-off values of PSAD and SUVmax were 0.22 μg/(L·cm
) and 8.02, respectively, and the AUCs for the diagnosis of prostate cancer in the gray zone alone and in combination were 0.628 (95%
0.530 to 0.720,
<0.05) and 0.806 (95%
0.718 to 0.876,
<0.05), 0.847 (95%
0.765 to 0.910,
<0.05), with sensitivities of 41.03%, 76.92%, and 74.36% and specificities of 79.41%, 89.71%, and 92.65%, respectively.
PSAD and SUVmax are increased in patients with gray zone prostate cancer, and the combination of PSAD and SUVmax is of high value in diagnosing gray zone prostate cancer.</abstract><cop>China</cop><pmid>38448374</pmid><doi>10.11817/j.issn.1672-7347.2023.230268</doi></addata></record> |
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| subjects | Humans Male Niacinamide - analogs & derivatives Oligopeptides Positron Emission Tomography Computed Tomography Prostate-Specific Antigen Prostatic Neoplasms - diagnostic imaging Retrospective Studies |
| title | Diagnostic value of 18 F - PSMA - 1007 PET/CT combined with prostate specific antigen derived indicators in gray area prostate cancer |
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