Suppression of the METTL3-m 6 A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity

The acidic metabolic byproducts within the tumor microenvironment (TME) hinder T cell effector functions. However, their effects on T cell infiltration remain largely unexplored. Leveraging the comprehensive The Cancer Genome Atlas dataset, we pinpoint 16 genes that correlate with extracellular acid...

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Veröffentlicht in:	Cell reports (Cambridge) 2024-02, Vol.43 (2), p.113796
Hauptverfasser:	Wang, Zhe, Shang, Jingzhe, Qiu, Yajing, Cheng, Hongcheng, Tao, Mengyuan, Xie, Ermei, Pei, Xin, Li, Wenhui, Zhang, Lianjun, Wu, Aiping, Li, Guideng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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