Targeting JMJD1C to selectively disrupt tumor T reg cell fitness enhances antitumor immunity

Regulatory T (T ) cells are critical for immune tolerance but also form a barrier to antitumor immunity. As therapeutic strategies involving T cell depletion are limited by concurrent autoimmune disorders, identification of intratumoral T cell-specific regulatory mechanisms is needed for selective t...

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Veröffentlicht in:	Nature immunology 2024-02
Hauptverfasser:	Long, Xuehui, Zhang, Sulin, Wang, Yuliang, Chen, Jingjing, Lu, Yanlai, Hou, Hui, Lin, Bichun, Li, Xutong, Shen, Chang, Yang, Ruirui, Zhu, Huamin, Cui, Rongrong, Cao, Duanhua, Chen, Geng, Wang, Dan, Chen, Yun, Zhai, Sulan, Zeng, Zhiqin, Wu, Shusheng, Lou, Mengting, Chen, Junhong, Zou, Jian, Zheng, Mingyue, Qin, Jun, Wang, Xiaoming
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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