First total synthesis of caerulomycin K: a case study on selective, multiple C-H functionalizations of pyridines
Caerulomycins, natural alkaloids with antimicrobial properties, have been previously synthesized starting with highly pre-functionalized building blocks or requiring many functional group manipulations. In this work, we report the first total synthesis of caerulomycin K, a diversely trifunctionalize...
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| Veröffentlicht in: | RSC advances 2024-02, Vol.14 (8), p.5542-5546 |
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| creator | Dimasi, Alessandro Failla, Mattia Montoli, Arianna Citarella, Andrea Ronchi, Paolo Passarella, Daniele Fasano, Valerio |
| description | Caerulomycins, natural alkaloids with antimicrobial properties, have been previously synthesized starting with highly pre-functionalized building blocks or requiring many functional group manipulations. In this work, we report the first total synthesis of caerulomycin K, a diversely trifunctionalized pyridine readily assembled in three steps exploiting the recent advancements in the C-H activation of N-heterocycles.
A radical change: the first 3-steps total synthesis of caerulomycin K was achieved exploiting Minisci chemistry using cheap starting materials. |
| doi_str_mv | 10.1039/d4ra00589a |
| format | Article |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Chemistry Functional groups Pyridines Synthesis |
| title | First total synthesis of caerulomycin K: a case study on selective, multiple C-H functionalizations of pyridines |
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