The role of CD56 bright NK cells in neurodegenerative disorders
Emerging evidence suggests a potential role for natural killer (NK) cells in neurodegenerative diseases, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. However, the precise function of NK cells in these diseases remains ambiguous. Th...
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| Veröffentlicht in: | Journal of neuroinflammation 2024-02, Vol.21 (1), p.48 |
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| container_title | Journal of neuroinflammation |
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| creator | Rodriguez-Mogeda, Carla van Ansenwoude, Chaja M J van der Molen, Lennart Strijbis, Eva M M Mebius, Reina E de Vries, Helga E |
| description | Emerging evidence suggests a potential role for natural killer (NK) cells in neurodegenerative diseases, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. However, the precise function of NK cells in these diseases remains ambiguous. The existence of two NK cell subsets, CD56
and CD56
NK cells, complicates the understanding of the contribution of NK cells in neurodegeneration as their functions within the context of neurodegenerative diseases may differ significantly. CD56
NK cells are potent cytokine secretors and are considered more immunoregulatory and less terminally differentiated than their mostly cytotoxic CD56
counterparts. Hence, this review focusses on NK cells, specifically on CD56
NK cells, and their role in neurodegenerative diseases. Moreover, it explores the mechanisms underlying their ability to enter the central nervous system. By consolidating current knowledge, we aim to provide a comprehensive overview on the role of CD56
NK cells in neurodegenerative diseases. Elucidating their impact on neurodegeneration may have implications for future therapeutic interventions, potentially ameliorating disease pathogenesis. |
| doi_str_mv | 10.1186/s12974-024-03040-8 |
| format | Article |
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and CD56
NK cells, complicates the understanding of the contribution of NK cells in neurodegeneration as their functions within the context of neurodegenerative diseases may differ significantly. CD56
NK cells are potent cytokine secretors and are considered more immunoregulatory and less terminally differentiated than their mostly cytotoxic CD56
counterparts. Hence, this review focusses on NK cells, specifically on CD56
NK cells, and their role in neurodegenerative diseases. Moreover, it explores the mechanisms underlying their ability to enter the central nervous system. By consolidating current knowledge, we aim to provide a comprehensive overview on the role of CD56
NK cells in neurodegenerative diseases. Elucidating their impact on neurodegeneration may have implications for future therapeutic interventions, potentially ameliorating disease pathogenesis.</description><identifier>EISSN: 1742-2094</identifier><identifier>DOI: 10.1186/s12974-024-03040-8</identifier><identifier>PMID: 38350967</identifier><language>eng</language><publisher>England</publisher><subject>Antineoplastic Agents ; Cell Differentiation ; Cytokines ; Humans ; Killer Cells, Natural ; Neurodegenerative Diseases</subject><ispartof>Journal of neuroinflammation, 2024-02, Vol.21 (1), p.48</ispartof><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38350967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez-Mogeda, Carla</creatorcontrib><creatorcontrib>van Ansenwoude, Chaja M J</creatorcontrib><creatorcontrib>van der Molen, Lennart</creatorcontrib><creatorcontrib>Strijbis, Eva M M</creatorcontrib><creatorcontrib>Mebius, Reina E</creatorcontrib><creatorcontrib>de Vries, Helga E</creatorcontrib><title>The role of CD56 bright NK cells in neurodegenerative disorders</title><title>Journal of neuroinflammation</title><addtitle>J Neuroinflammation</addtitle><description>Emerging evidence suggests a potential role for natural killer (NK) cells in neurodegenerative diseases, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. However, the precise function of NK cells in these diseases remains ambiguous. The existence of two NK cell subsets, CD56
and CD56
NK cells, complicates the understanding of the contribution of NK cells in neurodegeneration as their functions within the context of neurodegenerative diseases may differ significantly. CD56
NK cells are potent cytokine secretors and are considered more immunoregulatory and less terminally differentiated than their mostly cytotoxic CD56
counterparts. Hence, this review focusses on NK cells, specifically on CD56
NK cells, and their role in neurodegenerative diseases. Moreover, it explores the mechanisms underlying their ability to enter the central nervous system. By consolidating current knowledge, we aim to provide a comprehensive overview on the role of CD56
NK cells in neurodegenerative diseases. Elucidating their impact on neurodegeneration may have implications for future therapeutic interventions, potentially ameliorating disease pathogenesis.</description><subject>Antineoplastic Agents</subject><subject>Cell Differentiation</subject><subject>Cytokines</subject><subject>Humans</subject><subject>Killer Cells, Natural</subject><subject>Neurodegenerative Diseases</subject><issn>1742-2094</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjbkKwkAUABdBTDx-wELeD0T3ylVZeCAIVulDYl6Slc3BbiL491pobTFMMzCErBndMhYFO8t4HEqP8g-CSupFE-KyUHKP01g6ZG7tg1LB_YDPiCMi4dM4CF2yT2oE02mEroTD0Q8gN6qqB7hd4Y5aW1AttDiarsAKWzTZoJ4IhbKdKdDYJZmWmba4-npBNudTcrh4_Zg3WKS9UU1mXunvKP4GbyRjOp8</recordid><startdate>20240213</startdate><enddate>20240213</enddate><creator>Rodriguez-Mogeda, Carla</creator><creator>van Ansenwoude, Chaja M J</creator><creator>van der Molen, Lennart</creator><creator>Strijbis, Eva M M</creator><creator>Mebius, Reina E</creator><creator>de Vries, Helga E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20240213</creationdate><title>The role of CD56 bright NK cells in neurodegenerative disorders</title><author>Rodriguez-Mogeda, Carla ; van Ansenwoude, Chaja M J ; van der Molen, Lennart ; Strijbis, Eva M M ; Mebius, Reina E ; de Vries, Helga E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_383509673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antineoplastic Agents</topic><topic>Cell Differentiation</topic><topic>Cytokines</topic><topic>Humans</topic><topic>Killer Cells, Natural</topic><topic>Neurodegenerative Diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodriguez-Mogeda, Carla</creatorcontrib><creatorcontrib>van Ansenwoude, Chaja M J</creatorcontrib><creatorcontrib>van der Molen, Lennart</creatorcontrib><creatorcontrib>Strijbis, Eva M M</creatorcontrib><creatorcontrib>Mebius, Reina E</creatorcontrib><creatorcontrib>de Vries, Helga E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of neuroinflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodriguez-Mogeda, Carla</au><au>van Ansenwoude, Chaja M J</au><au>van der Molen, Lennart</au><au>Strijbis, Eva M M</au><au>Mebius, Reina E</au><au>de Vries, Helga E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of CD56 bright NK cells in neurodegenerative disorders</atitle><jtitle>Journal of neuroinflammation</jtitle><addtitle>J Neuroinflammation</addtitle><date>2024-02-13</date><risdate>2024</risdate><volume>21</volume><issue>1</issue><spage>48</spage><pages>48-</pages><eissn>1742-2094</eissn><abstract>Emerging evidence suggests a potential role for natural killer (NK) cells in neurodegenerative diseases, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. However, the precise function of NK cells in these diseases remains ambiguous. The existence of two NK cell subsets, CD56
and CD56
NK cells, complicates the understanding of the contribution of NK cells in neurodegeneration as their functions within the context of neurodegenerative diseases may differ significantly. CD56
NK cells are potent cytokine secretors and are considered more immunoregulatory and less terminally differentiated than their mostly cytotoxic CD56
counterparts. Hence, this review focusses on NK cells, specifically on CD56
NK cells, and their role in neurodegenerative diseases. Moreover, it explores the mechanisms underlying their ability to enter the central nervous system. By consolidating current knowledge, we aim to provide a comprehensive overview on the role of CD56
NK cells in neurodegenerative diseases. Elucidating their impact on neurodegeneration may have implications for future therapeutic interventions, potentially ameliorating disease pathogenesis.</abstract><cop>England</cop><pmid>38350967</pmid><doi>10.1186/s12974-024-03040-8</doi></addata></record> |
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| ispartof | Journal of neuroinflammation, 2024-02, Vol.21 (1), p.48 |
| issn | 1742-2094 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA/Free Journals; SpringerLink Journals - AutoHoldings; PubMed Central Open Access |
| subjects | Antineoplastic Agents Cell Differentiation Cytokines Humans Killer Cells, Natural Neurodegenerative Diseases |
| title | The role of CD56 bright NK cells in neurodegenerative disorders |
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