2'-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca 2+ concentrations

TRPM2 is a Ca permeable, non-selective cation channel in the plasma membrane that is involved in the innate immune response regulating, for example, chemotaxis in neutrophils and cytokine secretion in monocytes and macrophages. The intracellular adenine nucleotides ADP-ribose (ADPR) and 2'-deox...

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Veröffentlicht in:	Frontiers in immunology 2024, Vol.15, p.1294357
Hauptverfasser:	Pick, Jelena, Sander, Simon, Etzold, Stefanie, Rosche, Anette, Tidow, Henning, Guse, Andreas H, Fliegert, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Ribose - chemistry Adenosine Diphosphate Ribose - metabolism Adenosine Diphosphate Ribose - pharmacology Calcium Signaling HEK293 Cells Humans Kinetics TRPM Cation Channels - genetics TRPM Cation Channels - metabolism
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