METTL3/16-mediated m 6 A modification of ZNNT1 promotes hepatocellular carcinoma progression by activating ZNNT1/osteopontin/S100A9 positive feedback loop-mediated crosstalk between macrophages and tumour cells

Macrophages are the major components of tumour microenvironment, which play critical roles in tumour development. N -methyladenosine (m A) also contributes to tumour progression. However, the potential roles of m A in modulating macrophages in hepatocellular carcinoma (HCC) are poorly understood. He...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2024-04, Vol.261, p.109924
Hauptverfasser:	Wei, Huamei, Li, Wenchuan, Yang, Meng, Fang, Quan, Nian, Jiahui, Huang, Youguan, Wei, Qing, Huang, Zihua, Liu, Guoman, Xu, Zuoming, Hu, Anbin, Pu, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - genetics Cell Line, Tumor Feedback Humans Liver Neoplasms - drug therapy Liver Neoplasms - genetics Macrophages - metabolism Methyltransferases - genetics Methyltransferases - metabolism Methyltransferases - therapeutic use Osteopontin - genetics Osteopontin - metabolism Osteopontin - therapeutic use Tumor Microenvironment
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