T-type voltage-gated channels, Na + /Ca 2+ -exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration

Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding diseases characterized by progressive photoreceptor loss. IRD pathology has been linked to an excessive activation of cyclic nucleotide-gated channels (CNGC) leading to Na - and Ca -influx, subsequent activation...

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Veröffentlicht in:	Cell communication and signaling 2024-02, Vol.22 (1), p.92
Hauptverfasser:	Yan, Jie, Wang, Lan, Yang, Qian-Lu, Yang, Qian-Xi, He, Xinyi, Dong, Yujie, Hu, Zhulin, Seeliger, Mathias W, Jiao, Kangwei, Paquet-Durand, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calpain - metabolism Cell Death Egtazic Acid - analogs & derivatives Mice Photoreceptor Cells - metabolism Photoreceptor Cells - pathology Retinal Degeneration - metabolism Sirtuins - metabolism Sodium-Calcium Exchanger
Online-Zugang:	Volltext
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