AKT2 S128 /CCTα S315/319/323 -positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic resistance. Present study employed multi-omics, including phosphoproteomics, untargeted metabolomics and lipidomics, to demonstrate that the pAKT2 Ser and pCCTα Ser -positive cancer-associated fibro...

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Veröffentlicht in:	Signal transduction and targeted therapy 2024-01, Vol.9 (1), p.21
Hauptverfasser:	Chen, Jie, Zhang, Lingyuan, Zhu, Yuheng, Zhao, Di, Zhang, Jing, Zhu, Yanmeng, Pang, Jingyuan, Xiao, Yuanfan, Wu, Qingnan, Wang, Yan, Zhan, Qimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer-Associated Fibroblasts - metabolism Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Squamous Cell Carcinoma - drug therapy Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - metabolism Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction
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