Detection of sub-nmol amounts of the antiviral drug favipiravir in 19 F MRI using photo-chemically induced dynamic nuclear polarization
In biological tissues, F magnetic resonance (MR) enables the non-invasive, background-free detection of F-containing biomarkers. However, the signal-to-noise ratio (SNR) is usually low because biomarkers are typically present at low concentrations. Measurements at low magnetic fields further reduce...
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| creator | Bernarding, J Bruns, C Prediger, I Mützel, M Plaumann, M |
| description | In biological tissues,
F magnetic resonance (MR) enables the non-invasive, background-free detection of
F-containing biomarkers. However, the signal-to-noise ratio (SNR) is usually low because biomarkers are typically present at low concentrations. Measurements at low magnetic fields further reduce the SNR. In a proof-of-principal study we applied LED-based photo-chemically induced dynamic nuclear polarization (photo-CIDNP) to amplify the
F signal at 0.6 T. For the first time,
F MR imaging (MRI) and spectroscopy (MRS) of a fully biocompatible model system containing the antiviral drug favipiravir has been successfully performed. This fluorinated drug has been used to treat Ebola and COVID-19. Since the partially cyclic reaction scheme for photo-CIDNP allows for multiple data acquisitions, averaging further improved the SNR. The mean signal gain factor for
F has been estimated to be in the order of 10
. An in-plane resolution of 0.39 × 0.39 mm
enabled the analysis of spatially varying degrees of hyperpolarization. The minimal detectable amount of favipiravir per voxel was estimated to about 500 pmol. The results show that
F photo-CIDNP is a promising method for the non-invasive detection of suitable
F-containing drugs and other compounds with very low levels of the substance. |
| doi_str_mv | 10.1038/s41598-024-51454-4 |
| format | Article |
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F magnetic resonance (MR) enables the non-invasive, background-free detection of
F-containing biomarkers. However, the signal-to-noise ratio (SNR) is usually low because biomarkers are typically present at low concentrations. Measurements at low magnetic fields further reduce the SNR. In a proof-of-principal study we applied LED-based photo-chemically induced dynamic nuclear polarization (photo-CIDNP) to amplify the
F signal at 0.6 T. For the first time,
F MR imaging (MRI) and spectroscopy (MRS) of a fully biocompatible model system containing the antiviral drug favipiravir has been successfully performed. This fluorinated drug has been used to treat Ebola and COVID-19. Since the partially cyclic reaction scheme for photo-CIDNP allows for multiple data acquisitions, averaging further improved the SNR. The mean signal gain factor for
F has been estimated to be in the order of 10
. An in-plane resolution of 0.39 × 0.39 mm
enabled the analysis of spatially varying degrees of hyperpolarization. The minimal detectable amount of favipiravir per voxel was estimated to about 500 pmol. The results show that
F photo-CIDNP is a promising method for the non-invasive detection of suitable
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F magnetic resonance (MR) enables the non-invasive, background-free detection of
F-containing biomarkers. However, the signal-to-noise ratio (SNR) is usually low because biomarkers are typically present at low concentrations. Measurements at low magnetic fields further reduce the SNR. In a proof-of-principal study we applied LED-based photo-chemically induced dynamic nuclear polarization (photo-CIDNP) to amplify the
F signal at 0.6 T. For the first time,
F MR imaging (MRI) and spectroscopy (MRS) of a fully biocompatible model system containing the antiviral drug favipiravir has been successfully performed. This fluorinated drug has been used to treat Ebola and COVID-19. Since the partially cyclic reaction scheme for photo-CIDNP allows for multiple data acquisitions, averaging further improved the SNR. The mean signal gain factor for
F has been estimated to be in the order of 10
. An in-plane resolution of 0.39 × 0.39 mm
enabled the analysis of spatially varying degrees of hyperpolarization. The minimal detectable amount of favipiravir per voxel was estimated to about 500 pmol. The results show that
F photo-CIDNP is a promising method for the non-invasive detection of suitable
F-containing drugs and other compounds with very low levels of the substance.</description><subject>Amides</subject><subject>Biomarkers</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Pyrazines</subject><subject>Signal-To-Noise Ratio</subject><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjktKA0EYhBtBTNBcIIvwX6C1XwMzazXowo24D3-mezIt_Rj6ERgv4LWdgK6tTVEfBVWEbDm750y2D1nxpmspE4o2XDWKqiuyFkw1VEghVmST8ydb1IhO8e6GrGQrpFScr8n3kymmLzYGiAPkeqTBRwfoYw0lX1gZDWAo9mwTOtCpnmDAs52WuCCwAXgHe3h7f4WabTjBNMYSaT8ab3t0bl4quvZGg54DLgxC7Z3BBFN0mOwXXtbvyPWALpvNr9-S3f754_GFTvXojT5MyXpM8-Hvufy38AOOaFaY</recordid><startdate>20240117</startdate><enddate>20240117</enddate><creator>Bernarding, J</creator><creator>Bruns, C</creator><creator>Prediger, I</creator><creator>Mützel, M</creator><creator>Plaumann, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20240117</creationdate><title>Detection of sub-nmol amounts of the antiviral drug favipiravir in 19 F MRI using photo-chemically induced dynamic nuclear polarization</title><author>Bernarding, J ; Bruns, C ; Prediger, I ; Mützel, M ; Plaumann, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_382334113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amides</topic><topic>Biomarkers</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Pyrazines</topic><topic>Signal-To-Noise Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernarding, J</creatorcontrib><creatorcontrib>Bruns, C</creatorcontrib><creatorcontrib>Prediger, I</creatorcontrib><creatorcontrib>Mützel, M</creatorcontrib><creatorcontrib>Plaumann, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernarding, J</au><au>Bruns, C</au><au>Prediger, I</au><au>Mützel, M</au><au>Plaumann, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of sub-nmol amounts of the antiviral drug favipiravir in 19 F MRI using photo-chemically induced dynamic nuclear polarization</atitle><jtitle>Scientific reports</jtitle><addtitle>Sci Rep</addtitle><date>2024-01-17</date><risdate>2024</risdate><volume>14</volume><issue>1</issue><spage>1527</spage><pages>1527-</pages><eissn>2045-2322</eissn><abstract>In biological tissues,
F magnetic resonance (MR) enables the non-invasive, background-free detection of
F-containing biomarkers. However, the signal-to-noise ratio (SNR) is usually low because biomarkers are typically present at low concentrations. Measurements at low magnetic fields further reduce the SNR. In a proof-of-principal study we applied LED-based photo-chemically induced dynamic nuclear polarization (photo-CIDNP) to amplify the
F signal at 0.6 T. For the first time,
F MR imaging (MRI) and spectroscopy (MRS) of a fully biocompatible model system containing the antiviral drug favipiravir has been successfully performed. This fluorinated drug has been used to treat Ebola and COVID-19. Since the partially cyclic reaction scheme for photo-CIDNP allows for multiple data acquisitions, averaging further improved the SNR. The mean signal gain factor for
F has been estimated to be in the order of 10
. An in-plane resolution of 0.39 × 0.39 mm
enabled the analysis of spatially varying degrees of hyperpolarization. The minimal detectable amount of favipiravir per voxel was estimated to about 500 pmol. The results show that
F photo-CIDNP is a promising method for the non-invasive detection of suitable
F-containing drugs and other compounds with very low levels of the substance.</abstract><cop>England</cop><pmid>38233411</pmid><doi>10.1038/s41598-024-51454-4</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2045-2322 |
| ispartof | Scientific reports, 2024-01, Vol.14 (1), p.1527 |
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| source | SpringerOpen; MEDLINE; Full-Text Journals in Chemistry (Open access); Directory of Open Access Journals; Nature_OA刊; PubMed Central; EZB Electronic Journals Library |
| subjects | Amides Biomarkers Magnetic Resonance Imaging Magnetic Resonance Spectroscopy - methods Pyrazines Signal-To-Noise Ratio |
| title | Detection of sub-nmol amounts of the antiviral drug favipiravir in 19 F MRI using photo-chemically induced dynamic nuclear polarization |
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