ASTER: A Method to Predict Clinically Relevant Synthetic Lethal Genetic Interactions

A Synthetic Lethal (SL) interaction is a functional relationship between two genes or functional entities where the loss of either entity is viable but the loss of both is lethal. Such pairs can be used to develop targeted anticancer therapies with fewer side effects and reduced overtreatment. Howev...

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Veröffentlicht in:	IEEE journal of biomedical and health informatics 2024-03, Vol.28 (3), p.1785-1796
Hauptverfasser:	Liany, Herty, Jayagopal, Aishwarya, Huang, Dachuan, Lim, Jing Quan, NBH, Nur Izzah, Jeyasekharan, Anand, Ong, Choon Kiat, Rajan, Vaibhav
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Cancer Drugs Gene expression Gene Expression Profiling Genetics Genomics Humans Hypotheses hypothesis testing Lethality Neoplasms - drug therapy Neoplasms - genetics Side effects Statistical analysis synthetic lethality targeted therapy Testing Transcriptomics unsupervised learning
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