A Novel Scoring System for Humane Endpoints in Mice with Cecal Ligation and Puncture-Induced Sepsis

Animal-based research is essential to the study of sepsis pathophysiology, diagnostics, and therapeutics. However, animal models of sepsis are often associated with high mortality because of the difficulty in predicting imminent death based on premortem assessment of the animals. The use of validate...

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Veröffentlicht in:	Comparative medicine 2023-12, Vol.73 (6), p.446-460
Hauptverfasser:	Ferguson, Lindsey T, Rashied, Ammar A, Liang, Zhe, Yumoto, Tetsuya, Anyalebechi, Jerome C, Swift, David A, Hernandes, Marina S, Krafty, Robert T, Coopersmith, Craig M, Lee, Vanessa K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cecum - surgery Disease Models, Animal Female Humans Ligation - adverse effects Male Mice Mice, Inbred C57BL Punctures - adverse effects Sepsis
Online-Zugang:	Volltext
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