Early Biological Indicators of S-(1,2-Dichlorovinyl)-L-Cysteine Nephrotoxicity in the Rabbit

ABSTRACT The progression of changes in rabbit kidney function following dosing with the nephrotoxin S-(1,2-dichlorovinyl)-L-cysteine (DCVC, 20-50 mg/kg) was determined. Proteinuria was observed 0.5-1 hr after administration of DCVC at doses of 20 -50 mg/kg. Blood urea nitrogen levels, glomerular fil...

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Veröffentlicht in:	Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 1986, Vol.9 (3-4), p.285-303
Hauptverfasser:	Silber, P. M., Gandolfi, A. J., Brendel, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Urea Nitrogen Cysteine - analogs & derivatives Cysteine - toxicity Glomerular Filtration Rate Glycosuria - chemically induced Kidney - pathology Kidney - physiopathology Kidney Diseases - chemically induced Kidney Diseases - pathology Kidney Diseases - physiopathology Male Proteinuria - chemically induced Rabbits
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