Synthetic arrest of Man 5 GlcNAc 2 -PP-Dol increases procyclin mRNA level and induces cell death in the bloodstream form Trypanosoma brucei brucei

The biosynthesis of N-linked glycan precursors in the endoplasmic reticulum is important for many eukaryotes. In particular, the synthesis of Man GlcNAc -PP-dolichol (M5-DLO) at the cytoplasmic face of the endoplasmic reticulum is essential for maintaining cellular functions. In Trypanosoma brucei,...

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Veröffentlicht in:	Parasitology international 2024-04, Vol.99, p.102831
Hauptverfasser:	Nakanishi, Masayuki, Takezaki, Reo, Takeguchi, Masaki, Hino, Mami, Nomoto, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death Endoplasmic Reticulum - metabolism Glycosylation Protozoan Proteins - genetics Protozoan Proteins - metabolism RNA, Messenger - metabolism Trypanosoma brucei brucei - genetics
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