Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain

-GlcNAcylation is thought to play a role in the development of tau pathology in Alzheimer's disease because of its ability to modulate tau's aggregation propensity. -GlcNAcylation is regulated by 2 enzymes: -GlcNAc transferase and -GlcNAcase (OGA). Development of a PET tracer would therefo...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2023-10, Vol.64 (10), p.1588
Hauptverfasser:	Cook, Brendon E, Nag, Sangram, Arakawa, Ryosuke, Lin, Edward Yin-Shiang, Stratman, Nancy, Guckian, Kevin, Hering, Heike, Lulla, Mukesh, Choi, Jinkuk, Salinas, Cristian, Genung, Nathan E, Morén, Anton Forsberg, Bolin, Martin, Boscutti, Giulia, Plisson, Christophe, Martarello, Laurent, Halldin, Christer, Kaliszczak, Maciej A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-N-Acetylhexosaminidases Brain Humans Pyrans Rats
Online-Zugang:	Volltext
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