Improved transfection efficiency and reduced cytotoxicity of PAMAM derivatives by Histidine- Modified Nuclear Localization Signals

Polyamidoamine (PAMAM) dendrimers have been explored as an alternative to polyethylenimine (PEI) as a gene delivery carrier because of its relatively low cytotoxicity and excellent biocompatibility. The transfection efficiency of PAMAM dendrimers can be improved by the addition of nuclear localizati...

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Veröffentlicht in:	International journal of pharmaceutics 2023-08, p.123299
Hauptverfasser:	Lee, Jeil, Kwon, Yong-Eun, Edwards, Seth D, Guim, Hwanuk, Jae Jeong, Kyung
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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