Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy
Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. An ultrasound-responsive block copolymer was synthesized, comprising an end-functional Eosin Y fluorophore, 2-tetrahydropyranyl acrylate (THPA...
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| Veröffentlicht in: | Biomaterials science 2023-09, Vol.11 (18), p.6149-6159 |
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| container_issue | 18 |
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| container_title | Biomaterials science |
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| creator | Lin, Shanmeng Zhu, Liwei Li, Zhiying Yue, Siyuan Wang, Zhaohan Xu, Youwei Zhang, Yichuan Gao, Quan Chen, Jie Yin, Ting Niu, Lili Geng, Jin |
| description | Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. An ultrasound-responsive block copolymer was synthesized, comprising an end-functional Eosin Y fluorophore, 2-tetrahydropyranyl acrylate (THPA), and acrylate mannose (MAN). The block copolymer was then self-assembled to produce micelles. The chemotherapy drug dasatinib (DAS) and the sonodynamic therapy agent methylene blue (MB) were encapsulated by the self-assembly of the block copolymer. This targeted nanoparticle enables sonodynamic therapy through high-intensity focused ultrasound while triggering nanoparticle disassembly for controlled drug release. The ultrasound-mediated, non-invasive strategy provides external spatiotemporal control for targeted tumour treatment.
Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. |
| doi_str_mv | 10.1039/d3bm01101a |
| format | Article |
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Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction.</description><subject>Block copolymers</subject><subject>Glycopolymers</subject><subject>Mannose</subject><subject>Methylene blue</subject><subject>Micelles</subject><subject>Nanoparticles</subject><subject>Self-assembly</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0U1r3DAQBmBRWppls5feGwS5lIATySNb9nG7zRdsyaU5FiNLo62DbTmSXfC_j7abbKC6SDDPDMMrQr5wdskZlFcG6o5xzrj6QBYpEzIRhSg_Ht_ATsgqhCcWj5Qly_lncgIyixXOFuT3Yzt6FdzUm8RjGFwfmr9Id-2s3eDauUNPu0Zj22Kg1nk6Kr_DEQ01k2qp8dOOGmxjj59p01Oteh1bxj_o1TCfkk9WtQFXr_eSPN5c_9rcJduH2_vNeptokDAmudZWFZajlDrPhNBFwbmoM8uyGsoSeG50alNQyDA1GQdhgbG6zpUVIDXAknw7zB28e54wjFXXhP3Sqkc3hSothATBy3xPz_-jT27yfdwuqhykYFkpo7o4KO1dCB5tNfimU36uOKv2uVc_4PvPf7mvIz57HTnVHZojfUs5gq8H4IM-Vt8_Dl4ACgqHaQ</recordid><startdate>20230912</startdate><enddate>20230912</enddate><creator>Lin, Shanmeng</creator><creator>Zhu, Liwei</creator><creator>Li, Zhiying</creator><creator>Yue, Siyuan</creator><creator>Wang, Zhaohan</creator><creator>Xu, Youwei</creator><creator>Zhang, Yichuan</creator><creator>Gao, Quan</creator><creator>Chen, Jie</creator><creator>Yin, Ting</creator><creator>Niu, Lili</creator><creator>Geng, Jin</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2181-0718</orcidid><orcidid>https://orcid.org/0000-0002-9485-6138</orcidid></search><sort><creationdate>20230912</creationdate><title>Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy</title><author>Lin, Shanmeng ; Zhu, Liwei ; Li, Zhiying ; Yue, Siyuan ; Wang, Zhaohan ; Xu, Youwei ; Zhang, Yichuan ; Gao, Quan ; Chen, Jie ; Yin, Ting ; Niu, Lili ; Geng, Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-6ccfa8f1e77c6544c88114b5f05b399316dc2f23ae0e2d5134f300bb6af437c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Block copolymers</topic><topic>Glycopolymers</topic><topic>Mannose</topic><topic>Methylene blue</topic><topic>Micelles</topic><topic>Nanoparticles</topic><topic>Self-assembly</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Shanmeng</creatorcontrib><creatorcontrib>Zhu, Liwei</creatorcontrib><creatorcontrib>Li, Zhiying</creatorcontrib><creatorcontrib>Yue, Siyuan</creatorcontrib><creatorcontrib>Wang, Zhaohan</creatorcontrib><creatorcontrib>Xu, Youwei</creatorcontrib><creatorcontrib>Zhang, Yichuan</creatorcontrib><creatorcontrib>Gao, Quan</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Yin, Ting</creatorcontrib><creatorcontrib>Niu, Lili</creatorcontrib><creatorcontrib>Geng, Jin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Shanmeng</au><au>Zhu, Liwei</au><au>Li, Zhiying</au><au>Yue, Siyuan</au><au>Wang, Zhaohan</au><au>Xu, Youwei</au><au>Zhang, Yichuan</au><au>Gao, Quan</au><au>Chen, Jie</au><au>Yin, Ting</au><au>Niu, Lili</au><au>Geng, Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2023-09-12</date><risdate>2023</risdate><volume>11</volume><issue>18</issue><spage>6149</spage><epage>6159</epage><pages>6149-6159</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. An ultrasound-responsive block copolymer was synthesized, comprising an end-functional Eosin Y fluorophore, 2-tetrahydropyranyl acrylate (THPA), and acrylate mannose (MAN). The block copolymer was then self-assembled to produce micelles. The chemotherapy drug dasatinib (DAS) and the sonodynamic therapy agent methylene blue (MB) were encapsulated by the self-assembly of the block copolymer. This targeted nanoparticle enables sonodynamic therapy through high-intensity focused ultrasound while triggering nanoparticle disassembly for controlled drug release. The ultrasound-mediated, non-invasive strategy provides external spatiotemporal control for targeted tumour treatment.
Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37548310</pmid><doi>10.1039/d3bm01101a</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2181-0718</orcidid><orcidid>https://orcid.org/0000-0002-9485-6138</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biomaterials science, 2023-09, Vol.11 (18), p.6149-6159 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Block copolymers Glycopolymers Mannose Methylene blue Micelles Nanoparticles Self-assembly |
| title | Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy |
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