Engineering yeast for the production of plant terpenoids using synthetic biology approaches
Covering: 2011-2022 The low amounts of terpenoids produced in plants and the difficulty in synthesizing these complex structures have stimulated the production of terpenoid compounds in microbial hosts by metabolic engineering and synthetic biology approaches. Advances in engineering yeast for terpe...
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| Veröffentlicht in: | Natural product reports 2023-12, Vol.4 (12), p.1822-1848 |
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| creator | Bureau, Jean-Alexandre Oliva, Magdalena Escobar Dong, Yueming Ignea, Codruta |
| description | Covering: 2011-2022
The low amounts of terpenoids produced in plants and the difficulty in synthesizing these complex structures have stimulated the production of terpenoid compounds in microbial hosts by metabolic engineering and synthetic biology approaches. Advances in engineering yeast for terpenoid production will be covered in this review focusing on four directions: (1) manipulation of host metabolism, (2) rewiring and reconstructing metabolic pathways, (3) engineering the catalytic activity, substrate selectivity and product specificity of biosynthetic enzymes, and (4) localizing terpenoid production
via
enzymatic fusions and scaffolds, or subcellular compartmentalization.
Yeast cell factories represent an alternative solution for the sustainable production of plant terpenoids. |
| doi_str_mv | 10.1039/d3np00005b |
| format | Article |
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The low amounts of terpenoids produced in plants and the difficulty in synthesizing these complex structures have stimulated the production of terpenoid compounds in microbial hosts by metabolic engineering and synthetic biology approaches. Advances in engineering yeast for terpenoid production will be covered in this review focusing on four directions: (1) manipulation of host metabolism, (2) rewiring and reconstructing metabolic pathways, (3) engineering the catalytic activity, substrate selectivity and product specificity of biosynthetic enzymes, and (4) localizing terpenoid production
via
enzymatic fusions and scaffolds, or subcellular compartmentalization.
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The low amounts of terpenoids produced in plants and the difficulty in synthesizing these complex structures have stimulated the production of terpenoid compounds in microbial hosts by metabolic engineering and synthetic biology approaches. Advances in engineering yeast for terpenoid production will be covered in this review focusing on four directions: (1) manipulation of host metabolism, (2) rewiring and reconstructing metabolic pathways, (3) engineering the catalytic activity, substrate selectivity and product specificity of biosynthetic enzymes, and (4) localizing terpenoid production
via
enzymatic fusions and scaffolds, or subcellular compartmentalization.
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The low amounts of terpenoids produced in plants and the difficulty in synthesizing these complex structures have stimulated the production of terpenoid compounds in microbial hosts by metabolic engineering and synthetic biology approaches. Advances in engineering yeast for terpenoid production will be covered in this review focusing on four directions: (1) manipulation of host metabolism, (2) rewiring and reconstructing metabolic pathways, (3) engineering the catalytic activity, substrate selectivity and product specificity of biosynthetic enzymes, and (4) localizing terpenoid production
via
enzymatic fusions and scaffolds, or subcellular compartmentalization.
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| ispartof | Natural product reports, 2023-12, Vol.4 (12), p.1822-1848 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biology Catalytic activity Metabolic Engineering Metabolic pathways Metabolism Microorganisms Plants - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Substrates Synthetic Biology Terpenes Terpenes - chemistry Yeast Yeasts |
| title | Engineering yeast for the production of plant terpenoids using synthetic biology approaches |
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