Immunosuppressive Treatment for an anti-U 1 Ribonucleoprotein Antibody-positive Patient with Pulmonary Arterial Hypertension
A 34-year-old woman with pulmonary arterial hypertension (PAH) was admitted to the hospital. She had been diagnosed with PAH three years earlier and treated with triple vasodilator therapy. She was positive for anti-U ribonucleoprotein antibodies but did not show any other symptoms associated with a...
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| Veröffentlicht in: | Internal medicine (Tokyo, 1992) 1992), 2024-03, Vol.63 (5), p.671 |
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| container_title | Internal medicine (Tokyo, 1992) |
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| creator | Matsumoto, Kazuya Miyawaki, Yoshia Katsuyama, Takayuki Nakadoi, Takato Shidahara, Kenta Hirose, Kei Nawachi, Shoichi Asano, Yosuke Katayama, Yu Katsuyama, Eri Takano-Narazaki, Mariko Matsumoto, Yoshinori Mori, Atsushi Akagi, Satoshi Sada, Ken-Ei Wada, Jun |
| description | A 34-year-old woman with pulmonary arterial hypertension (PAH) was admitted to the hospital. She had been diagnosed with PAH three years earlier and treated with triple vasodilator therapy. She was positive for anti-U
ribonucleoprotein antibodies but did not show any other symptoms associated with autoimmune diseases. Corticosteroid and cyclophosphamide therapy was administered, suspecting the involvement of immunological pathophysiology. After 3 weeks, the mean pulmonary artery pressure decreased from 50 to 38 mmHg without any change in the vasodilators. Immunosuppressive therapy was effective in this patient with PAH with an anti-U
ribonucleoprotein-antibody-positive response and might be an option for patients with these specific features. |
| doi_str_mv | 10.2169/internalmedicine.1407-22 |
| format | Article |
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ribonucleoprotein antibodies but did not show any other symptoms associated with autoimmune diseases. Corticosteroid and cyclophosphamide therapy was administered, suspecting the involvement of immunological pathophysiology. After 3 weeks, the mean pulmonary artery pressure decreased from 50 to 38 mmHg without any change in the vasodilators. Immunosuppressive therapy was effective in this patient with PAH with an anti-U
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ribonucleoprotein antibodies but did not show any other symptoms associated with autoimmune diseases. Corticosteroid and cyclophosphamide therapy was administered, suspecting the involvement of immunological pathophysiology. After 3 weeks, the mean pulmonary artery pressure decreased from 50 to 38 mmHg without any change in the vasodilators. Immunosuppressive therapy was effective in this patient with PAH with an anti-U
ribonucleoprotein-antibody-positive response and might be an option for patients with these specific features.</description><subject>Adrenal Cortex Hormones</subject><subject>Adult</subject><subject>Antibodies, Antinuclear</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Pulmonary Arterial Hypertension - drug therapy</subject><subject>Ribonucleoproteins</subject><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFj9tKAzEQhoMgbT28guQFUjfJ2u1eFlHqXZF6XbLtlI4kk5CDsuDDm4JeFwZm4P8_-IYxLpu5kov-ESlDJGMdHHCPBHPZNp1Q6orNpG570Sn9NGU3KX02jV52vZqwqe7axVK1_Yz9vDlXyKcSQoSU8Av4NoLJDijzo4_cUJ2M4oNL_o6Dp7K34EP0GZD4qkaDP4wi-IT5TG9MxjP7jfnEN8U6TyaOfBWrJRrL12OAelNCT3fs-mhsgvu_fcseXl-2z2sRylDf2YWIrsK7f119sfALoBRYGg</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Matsumoto, Kazuya</creator><creator>Miyawaki, Yoshia</creator><creator>Katsuyama, Takayuki</creator><creator>Nakadoi, Takato</creator><creator>Shidahara, Kenta</creator><creator>Hirose, Kei</creator><creator>Nawachi, Shoichi</creator><creator>Asano, Yosuke</creator><creator>Katayama, Yu</creator><creator>Katsuyama, Eri</creator><creator>Takano-Narazaki, Mariko</creator><creator>Matsumoto, Yoshinori</creator><creator>Mori, Atsushi</creator><creator>Akagi, Satoshi</creator><creator>Sada, Ken-Ei</creator><creator>Wada, Jun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20240301</creationdate><title>Immunosuppressive Treatment for an anti-U 1 Ribonucleoprotein Antibody-positive Patient with Pulmonary Arterial Hypertension</title><author>Matsumoto, Kazuya ; Miyawaki, Yoshia ; Katsuyama, Takayuki ; Nakadoi, Takato ; Shidahara, Kenta ; Hirose, Kei ; Nawachi, Shoichi ; Asano, Yosuke ; Katayama, Yu ; Katsuyama, Eri ; Takano-Narazaki, Mariko ; Matsumoto, Yoshinori ; Mori, Atsushi ; Akagi, Satoshi ; Sada, Ken-Ei ; Wada, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_374682493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adrenal Cortex Hormones</topic><topic>Adult</topic><topic>Antibodies, Antinuclear</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Pulmonary Arterial Hypertension - drug therapy</topic><topic>Ribonucleoproteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Kazuya</creatorcontrib><creatorcontrib>Miyawaki, Yoshia</creatorcontrib><creatorcontrib>Katsuyama, Takayuki</creatorcontrib><creatorcontrib>Nakadoi, Takato</creatorcontrib><creatorcontrib>Shidahara, Kenta</creatorcontrib><creatorcontrib>Hirose, Kei</creatorcontrib><creatorcontrib>Nawachi, Shoichi</creatorcontrib><creatorcontrib>Asano, Yosuke</creatorcontrib><creatorcontrib>Katayama, Yu</creatorcontrib><creatorcontrib>Katsuyama, Eri</creatorcontrib><creatorcontrib>Takano-Narazaki, Mariko</creatorcontrib><creatorcontrib>Matsumoto, Yoshinori</creatorcontrib><creatorcontrib>Mori, Atsushi</creatorcontrib><creatorcontrib>Akagi, Satoshi</creatorcontrib><creatorcontrib>Sada, Ken-Ei</creatorcontrib><creatorcontrib>Wada, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Internal medicine (Tokyo, 1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Kazuya</au><au>Miyawaki, Yoshia</au><au>Katsuyama, Takayuki</au><au>Nakadoi, Takato</au><au>Shidahara, Kenta</au><au>Hirose, Kei</au><au>Nawachi, Shoichi</au><au>Asano, Yosuke</au><au>Katayama, Yu</au><au>Katsuyama, Eri</au><au>Takano-Narazaki, Mariko</au><au>Matsumoto, Yoshinori</au><au>Mori, Atsushi</au><au>Akagi, Satoshi</au><au>Sada, Ken-Ei</au><au>Wada, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppressive Treatment for an anti-U 1 Ribonucleoprotein Antibody-positive Patient with Pulmonary Arterial Hypertension</atitle><jtitle>Internal medicine (Tokyo, 1992)</jtitle><addtitle>Intern Med</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>63</volume><issue>5</issue><spage>671</spage><pages>671-</pages><eissn>1349-7235</eissn><abstract>A 34-year-old woman with pulmonary arterial hypertension (PAH) was admitted to the hospital. She had been diagnosed with PAH three years earlier and treated with triple vasodilator therapy. She was positive for anti-U
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| fulltext | fulltext |
| identifier | EISSN: 1349-7235 |
| ispartof | Internal medicine (Tokyo, 1992), 2024-03, Vol.63 (5), p.671 |
| issn | 1349-7235 |
| language | eng |
| recordid | cdi_pubmed_primary_37468249 |
| source | J-STAGE Free; MEDLINE; PubMed Central Open Access; PubMed Central |
| subjects | Adrenal Cortex Hormones Adult Antibodies, Antinuclear Female Humans Immunosuppressive Agents - therapeutic use Pulmonary Arterial Hypertension - drug therapy Ribonucleoproteins |
| title | Immunosuppressive Treatment for an anti-U 1 Ribonucleoprotein Antibody-positive Patient with Pulmonary Arterial Hypertension |
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