Distribution of 15- and 137-µ Diameter Microspheres in the Dog Lung in the Axial Plane
Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung. The lung injury corresponds to the peripheral distribution of labeled oleic acid. The basis for this distribution of oleic acid is not known. Our hypothesis for this nonuniform distribution i...
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| Veröffentlicht in: | Invest. Radiol.; (United States) 1986-08, Vol.21 (8), p.618-621 |
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| container_title | Invest. Radiol.; (United States) |
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| creator | CHILES, CAROLINE HEDLUND, LAURENCE W KUBEK, ROBERT J HARRIS, CRAIG SULLIVAN, DANIEL C TSAI, JOSEPH C PUTMAN, CHARLES E |
| description | Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung. The lung injury corresponds to the peripheral distribution of labeled oleic acid. The basis for this distribution of oleic acid is not known. Our hypothesis for this nonuniform distribution is that particle diameter plays a role in the subsequent distribution of inflused oleic acid and the resulting lung injury. We injected 15-µ microspheres Sr and then 137-µ microspheres (Ce) into the right atria of seven dogs, which were killed and the lungs removed. Analysis of the distribution of the two different diameter microspheres within axial slices from the left caudal lobe of each dog revealed a peripheral distribution of the larger diameter microspheres not seen with the smaller microspheres. |
| doi_str_mv | 10.1097/00004424-198608000-00003 |
| format | Article |
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Medical Center, Durham, NC</creatorcontrib><description>Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung. The lung injury corresponds to the peripheral distribution of labeled oleic acid. The basis for this distribution of oleic acid is not known. Our hypothesis for this nonuniform distribution is that particle diameter plays a role in the subsequent distribution of inflused oleic acid and the resulting lung injury. We injected 15-µ microspheres Sr and then 137-µ microspheres (Ce) into the right atria of seven dogs, which were killed and the lungs removed. Analysis of the distribution of the two different diameter microspheres within axial slices from the left caudal lobe of each dog revealed a peripheral distribution of the larger diameter microspheres not seen with the smaller microspheres.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-198608000-00003</identifier><identifier>PMID: 3744736</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987) ; ALKALINE EARTH ISOTOPES ; ANIMALS ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BODY ; CARDIOVASCULAR SYSTEM ; CERIUM 141 ; CERIUM ISOTOPES ; Cesium Radioisotopes ; DAYS LIVING RADIOISOTOPES ; DISTRIBUTION ; DOGS ; ELECTRON CAPTURE RADIOISOTOPES ; EVEN-ODD NUCLEI ; HEART ; HOURS LIVING RADIOISOTOPES ; INTERMEDIATE MASS NUCLEI ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; Lung - diagnostic imaging ; LUNGS ; MAMMALS ; MICROSPHERES ; NUCLEI ; Oleic Acid ; Oleic Acids - toxicity ; ORGANS ; PARTICLE SIZE ; Pulmonary Circulation ; Pulmonary Embolism - chemically induced ; Pulmonary Embolism - diagnostic imaging ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOISOTOPES ; Radionuclide Imaging ; RARE EARTH ISOTOPES ; RARE EARTH NUCLEI ; RESPIRATORY SYSTEM ; SIZE ; STRONTIUM 85 ; STRONTIUM ISOTOPES ; Strontium Radioisotopes ; TISSUE DISTRIBUTION ; VERTEBRATES</subject><ispartof>Invest. 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Medical Center, Durham, NC</creatorcontrib><title>Distribution of 15- and 137-µ Diameter Microspheres in the Dog Lung in the Axial Plane</title><title>Invest. Radiol.; (United States)</title><addtitle>Invest Radiol</addtitle><description>Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung. The lung injury corresponds to the peripheral distribution of labeled oleic acid. The basis for this distribution of oleic acid is not known. Our hypothesis for this nonuniform distribution is that particle diameter plays a role in the subsequent distribution of inflused oleic acid and the resulting lung injury. We injected 15-µ microspheres Sr and then 137-µ microspheres (Ce) into the right atria of seven dogs, which were killed and the lungs removed. Analysis of the distribution of the two different diameter microspheres within axial slices from the left caudal lobe of each dog revealed a peripheral distribution of the larger diameter microspheres not seen with the smaller microspheres.</description><subject>560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)</subject><subject>ALKALINE EARTH ISOTOPES</subject><subject>ANIMALS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BODY</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>CERIUM 141</subject><subject>CERIUM ISOTOPES</subject><subject>Cesium Radioisotopes</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DISTRIBUTION</subject><subject>DOGS</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>EVEN-ODD NUCLEI</subject><subject>HEART</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>Lung - diagnostic imaging</subject><subject>LUNGS</subject><subject>MAMMALS</subject><subject>MICROSPHERES</subject><subject>NUCLEI</subject><subject>Oleic Acid</subject><subject>Oleic Acids - toxicity</subject><subject>ORGANS</subject><subject>PARTICLE SIZE</subject><subject>Pulmonary Circulation</subject><subject>Pulmonary Embolism - chemically induced</subject><subject>Pulmonary Embolism - diagnostic imaging</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOISOTOPES</subject><subject>Radionuclide Imaging</subject><subject>RARE EARTH ISOTOPES</subject><subject>RARE EARTH NUCLEI</subject><subject>RESPIRATORY SYSTEM</subject><subject>SIZE</subject><subject>STRONTIUM 85</subject><subject>STRONTIUM ISOTOPES</subject><subject>Strontium Radioisotopes</subject><subject>TISSUE DISTRIBUTION</subject><subject>VERTEBRATES</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1OwzAQhS0EKqVwBCSLvcH2OP5ZVi1_UhEsQCwjx3EaQ5pUsavCwbgAJyOoZclsnt68p5HmQwgzesmoUVd0GCG4IMxoSfXgyO8KDtCYZSAJ5YweojGlnBJjjDxGJzG-DQ2uKIzQCJQQCuQYvc5DTH0oNil0Le4qzDKCbVtiBop8f-F5sCuffI8fguu7uK597yMOLU61x_NuiRebdvnnpx_BNvipsa0_RUeVbaI_2-sEvdxcP8_uyOLx9n42XZCOGQBilDG0UhkH7kqthdMZKAAomNTKcuuVLzSUXEtfgK0GlYo7yUSmvTSZhAm62N3tYgp5dCF5V7uubb1LeTYQAc6H0vmutN4UK1_m6z6sbP-Z7ykMudjl264Zfo3vzWbr-7z2tkl1_h9r-AFMymxF</recordid><startdate>198608</startdate><enddate>198608</enddate><creator>CHILES, CAROLINE</creator><creator>HEDLUND, LAURENCE W</creator><creator>KUBEK, ROBERT J</creator><creator>HARRIS, CRAIG</creator><creator>SULLIVAN, DANIEL C</creator><creator>TSAI, JOSEPH C</creator><creator>PUTMAN, CHARLES E</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>OTOTI</scope></search><sort><creationdate>198608</creationdate><title>Distribution of 15- and 137-µ Diameter Microspheres in the Dog Lung in the Axial Plane</title><author>CHILES, CAROLINE ; HEDLUND, LAURENCE W ; KUBEK, ROBERT J ; HARRIS, CRAIG ; SULLIVAN, DANIEL C ; TSAI, JOSEPH C ; PUTMAN, CHARLES E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o1933-97990f75232cd884c8537333b1687a2ae7eb83d286eb3af286672c61458e69563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)</topic><topic>ALKALINE EARTH ISOTOPES</topic><topic>ANIMALS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BODY</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>CERIUM 141</topic><topic>CERIUM ISOTOPES</topic><topic>Cesium Radioisotopes</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DISTRIBUTION</topic><topic>DOGS</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>EVEN-ODD NUCLEI</topic><topic>HEART</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>Lung - diagnostic imaging</topic><topic>LUNGS</topic><topic>MAMMALS</topic><topic>MICROSPHERES</topic><topic>NUCLEI</topic><topic>Oleic Acid</topic><topic>Oleic Acids - toxicity</topic><topic>ORGANS</topic><topic>PARTICLE SIZE</topic><topic>Pulmonary Circulation</topic><topic>Pulmonary Embolism - chemically induced</topic><topic>Pulmonary Embolism - diagnostic imaging</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOISOTOPES</topic><topic>Radionuclide Imaging</topic><topic>RARE EARTH ISOTOPES</topic><topic>RARE EARTH NUCLEI</topic><topic>RESPIRATORY SYSTEM</topic><topic>SIZE</topic><topic>STRONTIUM 85</topic><topic>STRONTIUM ISOTOPES</topic><topic>Strontium Radioisotopes</topic><topic>TISSUE DISTRIBUTION</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHILES, CAROLINE</creatorcontrib><creatorcontrib>HEDLUND, LAURENCE W</creatorcontrib><creatorcontrib>KUBEK, ROBERT J</creatorcontrib><creatorcontrib>HARRIS, CRAIG</creatorcontrib><creatorcontrib>SULLIVAN, DANIEL C</creatorcontrib><creatorcontrib>TSAI, JOSEPH C</creatorcontrib><creatorcontrib>PUTMAN, CHARLES E</creatorcontrib><creatorcontrib>Duke Univ. 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Radiol.; (United States)</jtitle><addtitle>Invest Radiol</addtitle><date>1986-08</date><risdate>1986</risdate><volume>21</volume><issue>8</issue><spage>618</spage><epage>621</epage><pages>618-621</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung. The lung injury corresponds to the peripheral distribution of labeled oleic acid. The basis for this distribution of oleic acid is not known. Our hypothesis for this nonuniform distribution is that particle diameter plays a role in the subsequent distribution of inflused oleic acid and the resulting lung injury. We injected 15-µ microspheres Sr and then 137-µ microspheres (Ce) into the right atria of seven dogs, which were killed and the lungs removed. Analysis of the distribution of the two different diameter microspheres within axial slices from the left caudal lobe of each dog revealed a peripheral distribution of the larger diameter microspheres not seen with the smaller microspheres.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>3744736</pmid><doi>10.1097/00004424-198608000-00003</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-9996 |
| ispartof | Invest. Radiol.; (United States), 1986-08, Vol.21 (8), p.618-621 |
| issn | 0020-9996 1536-0210 |
| language | eng |
| recordid | cdi_pubmed_primary_3744736 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | 560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987) ALKALINE EARTH ISOTOPES ANIMALS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BODY CARDIOVASCULAR SYSTEM CERIUM 141 CERIUM ISOTOPES Cesium Radioisotopes DAYS LIVING RADIOISOTOPES DISTRIBUTION DOGS ELECTRON CAPTURE RADIOISOTOPES EVEN-ODD NUCLEI HEART HOURS LIVING RADIOISOTOPES INTERMEDIATE MASS NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPES Lung - diagnostic imaging LUNGS MAMMALS MICROSPHERES NUCLEI Oleic Acid Oleic Acids - toxicity ORGANS PARTICLE SIZE Pulmonary Circulation Pulmonary Embolism - chemically induced Pulmonary Embolism - diagnostic imaging RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES Radionuclide Imaging RARE EARTH ISOTOPES RARE EARTH NUCLEI RESPIRATORY SYSTEM SIZE STRONTIUM 85 STRONTIUM ISOTOPES Strontium Radioisotopes TISSUE DISTRIBUTION VERTEBRATES |
| title | Distribution of 15- and 137-µ Diameter Microspheres in the Dog Lung in the Axial Plane |
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