PD-1 Hi CAR-T cells provide superior protection against solid tumors

Chimeric antigen receptor (CAR)-T cell therapy has emerged as a promising treatment option for several hematologic cancers. However, efforts to achieve the same level of therapeutic success in solid tumors have largely failed mainly due to CAR-T cell exhaustion and poor persistence at the tumor site...

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Veröffentlicht in:	Frontiers in immunology 2023, Vol.14, p.1187850
Hauptverfasser:	Sailer, Cooper J, Hong, Yeonsun, Dahal, Ankit, Ryan, Allison T, Mir, Sana, Gerber, Scott A, Reagan, Patrick M, Kim, Minsoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antibodies Hematologic Neoplasms Humans Mice Neoplasms - therapy Programmed Cell Death 1 Receptor Tumor Microenvironment
Online-Zugang:	Volltext
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