A bi-functional PARP-HDAC inhibitor with activity in Ewing sarcoma

Histone deacetylase (HDAC) inhibition has been shown to induce pharmacological "BRCAness" in cancer cells with proficient DNA repair activity. This provides a rationale for exploring combination treatments with HDAC and poly-(ADP-ribose)-polymerase (PARP) inhibition in cancer types that ar...

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Veröffentlicht in:	Clinical cancer research 2023-06
Hauptverfasser:	Ramos, Louise, Truong, Sarah, Zhai, Beibei, Joshi, Jay, Ghaidi, Fariba, Lizardo, Michael M, Shyp, Taras, Kung, Sonia H Y, Rezakhanlou, Alireza M, Oo, Htoo Zarni, Adomat, Hans, Le Bihan, Stephane, Collins, Colin, Bacha, Jeffrey, Brown, Dennis, Langlands, John, Shen, Wang, Lallous, Nada, Sorensen, Poul H, Daugaard, Mads
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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