Clinical Perspective on Human Immunodeficiency Virus Care of Ukrainian War Refugees in Poland
The Russian invasion of Ukraine forced migration for safety, protection, and assistance. Poland is the primary sheltering country for Ukrainian refugees, providing support including medical care, which resulted in the rapid ∼15% increase in the number of followed-up people with human immunodeficienc...
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| Veröffentlicht in: | Clinical infectious diseases 2023-05, Vol.76 (10), p.1708 |
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| creator | Parczewski, Miłosz Jabłonowska, Elżbieta Wójcik-Cichy, Kamila Zhyvytsia, Dmytro Witak-Jędra, Magdalena Leszczyszyn-Pynka, Magdalena Aksak-Wąs, Bogusz Siwak, Ewa Cielniak, Iwona Olczak, Anita Szymczak, Aleksandra Szetela, Bartosz Bociąga-Jasik, Monika Kalinowska-Nowak, Anna Mularska, Elżbieta Witor, Adam Jakubowski, Paweł Hlebowicz, Maria Rozpłochowski, Błażej Łojewski, Władysław Scheibe, Kaja Serwin, Karol |
| description | The Russian invasion of Ukraine forced migration for safety, protection, and assistance. Poland is the primary sheltering country for Ukrainian refugees, providing support including medical care, which resulted in the rapid ∼15% increase in the number of followed-up people with human immunodeficiency virus (HIV) (PWH) in the country. Here, we present the national experience on HIV care provided for refugees from Ukraine.
Clinical, antiretroviral, immunological, and virologic data from 955 Ukrainian PWH entering care in Poland since February 2022 were analyzed. The dataset included both antiretroviral-treated (n = 851) and newly diagnosed (n = 104) patients. In 76 cases, protease/reverse transcriptase/integrase sequencing was performed to identify drug resistance and subtype.
Most (70.05%) of the patients were female, with a predominance of heterosexual (70.3%) transmissions. Anti-hepatitis C antibody and hepatitis B antigen were present in 28.7% and 2.9% of the patients, respectively. A history of tuberculosis was reported in 10.1% of cases. Among previously treated patients, the viral suppression rate was 89.6%; 77.3% of newly HIV diagnosed cases were diagnosed late (with lymphocyte CD4 count |
| doi_str_mv | 10.1093/cid/ciad116 |
| format | Article |
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Clinical, antiretroviral, immunological, and virologic data from 955 Ukrainian PWH entering care in Poland since February 2022 were analyzed. The dataset included both antiretroviral-treated (n = 851) and newly diagnosed (n = 104) patients. In 76 cases, protease/reverse transcriptase/integrase sequencing was performed to identify drug resistance and subtype.
Most (70.05%) of the patients were female, with a predominance of heterosexual (70.3%) transmissions. Anti-hepatitis C antibody and hepatitis B antigen were present in 28.7% and 2.9% of the patients, respectively. A history of tuberculosis was reported in 10.1% of cases. Among previously treated patients, the viral suppression rate was 89.6%; 77.3% of newly HIV diagnosed cases were diagnosed late (with lymphocyte CD4 count <350 cells/μL or AIDS). The A6 variant was observed in 89.0% of sequences. Transmitted mutations in the reverse transcriptase were found in 15.4% treatment-naive cases. Two patients with treatment failure exhibited multiclass drug resistance.
Migration from Ukraine influences the characteristics of HIV epidemics in Europe, with an increase in the proportion of women and hepatitis C coinfected patients. Antiretroviral treatment efficacy among previously treated refugees was high, with new HIV cases frequently diagnosed late. The A6 subtype was the most common variant.</description><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciad116</identifier><identifier>PMID: 37253127</identifier><language>eng</language><publisher>United States</publisher><subject>Anti-HIV Agents - therapeutic use ; Anti-Retroviral Agents - therapeutic use ; Female ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Humans ; Male ; Poland - epidemiology ; Refugees ; RNA-Directed DNA Polymerase - therapeutic use</subject><ispartof>Clinical infectious diseases, 2023-05, Vol.76 (10), p.1708</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-1869-1084</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37253127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parczewski, Miłosz</creatorcontrib><creatorcontrib>Jabłonowska, Elżbieta</creatorcontrib><creatorcontrib>Wójcik-Cichy, Kamila</creatorcontrib><creatorcontrib>Zhyvytsia, Dmytro</creatorcontrib><creatorcontrib>Witak-Jędra, Magdalena</creatorcontrib><creatorcontrib>Leszczyszyn-Pynka, Magdalena</creatorcontrib><creatorcontrib>Aksak-Wąs, Bogusz</creatorcontrib><creatorcontrib>Siwak, Ewa</creatorcontrib><creatorcontrib>Cielniak, Iwona</creatorcontrib><creatorcontrib>Olczak, Anita</creatorcontrib><creatorcontrib>Szymczak, Aleksandra</creatorcontrib><creatorcontrib>Szetela, Bartosz</creatorcontrib><creatorcontrib>Bociąga-Jasik, Monika</creatorcontrib><creatorcontrib>Kalinowska-Nowak, Anna</creatorcontrib><creatorcontrib>Mularska, Elżbieta</creatorcontrib><creatorcontrib>Witor, Adam</creatorcontrib><creatorcontrib>Jakubowski, Paweł</creatorcontrib><creatorcontrib>Hlebowicz, Maria</creatorcontrib><creatorcontrib>Rozpłochowski, Błażej</creatorcontrib><creatorcontrib>Łojewski, Władysław</creatorcontrib><creatorcontrib>Scheibe, Kaja</creatorcontrib><creatorcontrib>Serwin, Karol</creatorcontrib><title>Clinical Perspective on Human Immunodeficiency Virus Care of Ukrainian War Refugees in Poland</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>The Russian invasion of Ukraine forced migration for safety, protection, and assistance. Poland is the primary sheltering country for Ukrainian refugees, providing support including medical care, which resulted in the rapid ∼15% increase in the number of followed-up people with human immunodeficiency virus (HIV) (PWH) in the country. Here, we present the national experience on HIV care provided for refugees from Ukraine.
Clinical, antiretroviral, immunological, and virologic data from 955 Ukrainian PWH entering care in Poland since February 2022 were analyzed. The dataset included both antiretroviral-treated (n = 851) and newly diagnosed (n = 104) patients. In 76 cases, protease/reverse transcriptase/integrase sequencing was performed to identify drug resistance and subtype.
Most (70.05%) of the patients were female, with a predominance of heterosexual (70.3%) transmissions. Anti-hepatitis C antibody and hepatitis B antigen were present in 28.7% and 2.9% of the patients, respectively. A history of tuberculosis was reported in 10.1% of cases. Among previously treated patients, the viral suppression rate was 89.6%; 77.3% of newly HIV diagnosed cases were diagnosed late (with lymphocyte CD4 count <350 cells/μL or AIDS). The A6 variant was observed in 89.0% of sequences. Transmitted mutations in the reverse transcriptase were found in 15.4% treatment-naive cases. Two patients with treatment failure exhibited multiclass drug resistance.
Migration from Ukraine influences the characteristics of HIV epidemics in Europe, with an increase in the proportion of women and hepatitis C coinfected patients. Antiretroviral treatment efficacy among previously treated refugees was high, with new HIV cases frequently diagnosed late. The A6 subtype was the most common variant.</description><subject>Anti-HIV Agents - therapeutic use</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Female</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Poland - epidemiology</subject><subject>Refugees</subject><subject>RNA-Directed DNA Polymerase - therapeutic use</subject><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j11LwzAYhYMgbk6vvJf8gWo-mqS9lKJuMHCI0ysZb5M3Em2zkq7C_r0B9eJwbp5z4CHkirMbzmp5a4PLAce5PiFzrqQptKr5jJyP4ydjnFdMnZGZNEJJLsycvDddiMFCRzeYxgHtIXwj3Ue6nHqIdNX3U9w79MEGjPZIX0OaRtpAypCn268EeZ7BN0j0Gf30gTjSEOlm30F0F-TUQzfi5V8vyPbh_qVZFuunx1Vzty4GzqpDIUohPROitta0YGstStYKrdAq0Ji9AFsnSl9VlTKsbK2sMq5bA1xpUZdyQa5_f4ep7dHthhR6SMfdv6f8AWlNUvE</recordid><startdate>20230524</startdate><enddate>20230524</enddate><creator>Parczewski, Miłosz</creator><creator>Jabłonowska, Elżbieta</creator><creator>Wójcik-Cichy, Kamila</creator><creator>Zhyvytsia, Dmytro</creator><creator>Witak-Jędra, Magdalena</creator><creator>Leszczyszyn-Pynka, Magdalena</creator><creator>Aksak-Wąs, Bogusz</creator><creator>Siwak, Ewa</creator><creator>Cielniak, Iwona</creator><creator>Olczak, Anita</creator><creator>Szymczak, Aleksandra</creator><creator>Szetela, Bartosz</creator><creator>Bociąga-Jasik, Monika</creator><creator>Kalinowska-Nowak, Anna</creator><creator>Mularska, Elżbieta</creator><creator>Witor, Adam</creator><creator>Jakubowski, Paweł</creator><creator>Hlebowicz, Maria</creator><creator>Rozpłochowski, Błażej</creator><creator>Łojewski, Władysław</creator><creator>Scheibe, Kaja</creator><creator>Serwin, Karol</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0003-1869-1084</orcidid></search><sort><creationdate>20230524</creationdate><title>Clinical Perspective on Human Immunodeficiency Virus Care of Ukrainian War Refugees in Poland</title><author>Parczewski, Miłosz ; 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Poland is the primary sheltering country for Ukrainian refugees, providing support including medical care, which resulted in the rapid ∼15% increase in the number of followed-up people with human immunodeficiency virus (HIV) (PWH) in the country. Here, we present the national experience on HIV care provided for refugees from Ukraine.
Clinical, antiretroviral, immunological, and virologic data from 955 Ukrainian PWH entering care in Poland since February 2022 were analyzed. The dataset included both antiretroviral-treated (n = 851) and newly diagnosed (n = 104) patients. In 76 cases, protease/reverse transcriptase/integrase sequencing was performed to identify drug resistance and subtype.
Most (70.05%) of the patients were female, with a predominance of heterosexual (70.3%) transmissions. Anti-hepatitis C antibody and hepatitis B antigen were present in 28.7% and 2.9% of the patients, respectively. A history of tuberculosis was reported in 10.1% of cases. Among previously treated patients, the viral suppression rate was 89.6%; 77.3% of newly HIV diagnosed cases were diagnosed late (with lymphocyte CD4 count <350 cells/μL or AIDS). The A6 variant was observed in 89.0% of sequences. Transmitted mutations in the reverse transcriptase were found in 15.4% treatment-naive cases. Two patients with treatment failure exhibited multiclass drug resistance.
Migration from Ukraine influences the characteristics of HIV epidemics in Europe, with an increase in the proportion of women and hepatitis C coinfected patients. Antiretroviral treatment efficacy among previously treated refugees was high, with new HIV cases frequently diagnosed late. The A6 subtype was the most common variant.</abstract><cop>United States</cop><pmid>37253127</pmid><doi>10.1093/cid/ciad116</doi><orcidid>https://orcid.org/0000-0003-1869-1084</orcidid></addata></record> |
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| subjects | Anti-HIV Agents - therapeutic use Anti-Retroviral Agents - therapeutic use Female HIV Infections - drug therapy HIV Infections - epidemiology Humans Male Poland - epidemiology Refugees RNA-Directed DNA Polymerase - therapeutic use |
| title | Clinical Perspective on Human Immunodeficiency Virus Care of Ukrainian War Refugees in Poland |
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