Clinical phase II trial of recombinant dna interferon (interferon alfa 2b) in patients with metastatic malignant melanoma

Twenty‐four patients with historically proven metastatic malignant melanoma were included in a Phase II trial of human DNA recombinant interferon (rDNA IFNα2). They were given 10 × 106 IU of IFNα2 subcutaneously three times a week until progression of disease or major intolerance developed. Twenty‐...

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Veröffentlicht in:	Cancer 1986-07, Vol.58 (2), p.215-218
Hauptverfasser:	Dorval, Thierry, Palangie, Thao, Jouve, Michel, Garcia‐Giralt, Emilio, Israel, Lucien, Falcoff, Ernesto, Schwab, Denis, Pouillart, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Dermatology Drug Evaluation Female Humans Interferon Type I - adverse effects Interferon Type I - therapeutic use Leukopenia - chemically induced Liver - drug effects Male Medical sciences Melanoma - drug therapy Middle Aged Neoplasm Metastasis Recombinant Proteins - therapeutic use Skin Neoplasms - drug therapy Thrombocytopenia - chemically induced Tumors of the skin and soft tissue. Premalignant lesions
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