Effect of warfarin on formation and growth of pre-neoplastic lesions in chemically induced colorectal cancer in the rat

Anticoagulant drugs are known to have an effect on tumour growth. However, the mechanisms by which they act are poorly understood, and have therefore been investigated in this study. Wistar rats were given eight weekly subcutaneous injections of azoxymethane, at a dose of 10 mg kg−1 week−1. Followin...

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Veröffentlicht in:	British journal of surgery 1986-06, Vol.73 (6), p.487-489
Hauptverfasser:	Goeting, Nicola L. M., Trotter, G. A., Taylor, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - drug therapy Adenoma - ultrastructure Animals Antineoplastic agents Applied sciences Azoxymethane Biological and medical sciences carcinogenesis Colon - ultrastructure Colonic Neoplasms - drug therapy Colorectal cancer Disease Models, Animal Exact sciences and technology General aspects Intestinal Mucosa - ultrastructure Male Medical sciences Microscopy, Electron, Scanning Other techniques and industries Pharmacology. Drug treatments Precancerous Conditions - drug therapy Random Allocation Rats Rats, Inbred Strains Rectal Neoplasms - drug therapy Rectum - ultrastructure warfarin Warfarin - therapeutic use
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