L-deamino-8-d-arginine vasopressin treatment in pregnancy and neonatal outcome: a report of three cases

Three women with neurohypophyseal diabetes insipidus, treated for prolonged periods, including pregnancy, with L-deamino-8-d-arginine vasopressin, gave birth in our hospital. Two of the infants had severe congenital heart disease, one of which was associated with trisomy 21. The third baby, born pre...

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Veröffentlicht in:American journal of perinatology 1986-07, Vol.3 (3), p.165-167
Hauptverfasser: LINDER, N, MATOTH, I, OHEL, G, YOURISH, D, TAMIR, I
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container_issue 3
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container_title American journal of perinatology
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creator LINDER, N
MATOTH, I
OHEL, G
YOURISH, D
TAMIR, I
description Three women with neurohypophyseal diabetes insipidus, treated for prolonged periods, including pregnancy, with L-deamino-8-d-arginine vasopressin, gave birth in our hospital. Two of the infants had severe congenital heart disease, one of which was associated with trisomy 21. The third baby, born prematurely, presented with mild intrauterine growth retardation; at the age of 21 months, the boy had severe failure to thrive, hypotonia, and motor retardation. These three cases raise doubts as to the safety of diabetes insipidus or its treatment in pregnancy.
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source MEDLINE; Thieme Connect Journals
subjects Abnormalities, Drug-Induced - etiology
Adult
Biological and medical sciences
Deamino Arginine Vasopressin - adverse effects
Diabetes Insipidus - drug therapy
Drug toxicity and drugs side effects treatment
Female
Humans
Infant, Newborn
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Pregnancy
Pregnancy Complications - drug therapy
Prenatal Exposure Delayed Effects
title L-deamino-8-d-arginine vasopressin treatment in pregnancy and neonatal outcome: a report of three cases
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